Age-related changes of task-specific brain activity in normal aging

Ho, Ming‐Chung; Chou, Chia-Yi; Huang, Chin-Fei; Lin, Yu‐Te; Shih, Ching-Sen; Han, Shiang-Yi; Shen, Ming-Hsun; Chen, Tsung-Ching; Liang, Chi-lin; Lu, Ming-Chi; Liu, Chia‐Ju

doi:10.1016/j.neulet.2011.11.057

Cited by 34 publications

(29 citation statements)

References 24 publications

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“…It has been demonstrated that a decrease of phaselocking and phase coherence caused by aging was accompanied by increased activity in the late (P3, 280-450 ms) theta response over the frontal and temporofrontal areas, and that this late component may reflect the effect of higher-order cognitive functions [37]. Increased activity in the elderly -in our study we have found stability -it is considered to be associated with enhanced memory performance [38].…”

Section: Young Adultssupporting

confidence: 62%

Stability of Auditory Discrimination and Novelty Processing in Physiological Aging

Raggi

Tasca

Rundo

et al. 2013

Behavioural Neurology

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Abstract. Complex higher-order cognitive functions and their possible changes with aging are mandatory objectives of cognitive neuroscience. Event-related potentials (ERPs) allow investigators to probe the earliest stages of information processing. N100, Mismatch negativity (MMN) and P3a are auditory ERP components that reflect automatic sensory discrimination. The aim of the present study was to determine if N100, MMN and P3a parameters are stable in healthy aged subjects, compared to those of normal young adults. Normal young adults and older participants were assessed using standardized cognitive functional instruments and their ERPs were obtained with an auditory stimulation at two different interstimulus intervals, during a passive paradigm. All individuals were within the normal range on cognitive tests. No significant differences were found for any ERP parameters obtained from the two age groups. This study shows that aging is characterized by a stability of the auditory discrimination and novelty processing. This is important for the arrangement of normative for the detection of subtle preclinical changes due to abnormal brain aging.

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Section: Young Adultssupporting

confidence: 62%

Stability of Auditory Discrimination and Novelty Processing in Physiological Aging

Raggi

Tasca

Rundo

et al. 2013

Behavioural Neurology

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“…Although apparently not explored in the equiprobable Go/NoGo task, ERP component latencies tend to show little if any change in the early sensory components such as P1 (when assessed) and N1 (Anguera and Gazzaley, 2011;Beck et al, 1980;Čeponienė et al, 2008;Ford et al, 1979;Goodin et al, 1978;Ho et al, 2012;Pfefferbaum et al, 1980;Yordanova et al, 2004).…”

Section: Fig 1 About Herementioning

confidence: 98%

Sequential processing in young and older adults in the equiprobable auditory Go/NoGo task

Barry

Blasio

Cave

2016

Clinical Neurophysiology

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Objective: We recently proposed a sequential processing schema for the equiprobable auditory Go/NoGo task, based on a principal components analysis (PCA) of event-related potentials (ERPs) from a university student sample. Here we sought to replicate the schema, and use it to explore processing in well-functioning older adults. Methods: We compared behavioural responding and ERPs of 20 independent-living older adults (M age = 68.2 years) to data from a sex-and handedness-matched group of university students (M age = 20.4 years). ERPs had substantial latency differences between the groups, and hence were subjected to separate group temporal PCAs. Results: Component latencies were systematically increased in the older group by some 26%, with no significant increase in RT or error rates. Despite some differences in their identified components, each group displayed differential component responsivity to Go versus NoGo; this was reduced in the older participants. Conclusion: The results support our processing schema, and provide insight into the processing stages in well-functioning older adults. Significance: Understanding the perceptual and cognitive processing stages in normal ageing is a pre-requisite for research on mild cognitive impairment and dementia. This study may also provide a simple paradigm and schema suitable for further exploration of functionality in ageing. Highlights• A PCA derived sequential processing Go/NoGo schema was confirmed in young adults, with similar processing in healthy older adults.• Older adults had comparable Go RT and Go/NoGo error rates, increased latencies and smaller, less differentiated Go/NoGo P3s, and N2c was absent.• Go/NoGo processing by Older adults may reflect less specialist processing regions, requiring more effort. ABSTRACT Objective:We recently proposed a sequential processing schema for the equiprobable auditory Go/NoGo task, based on a principal components analysis (PCA) of event-related potentials (ERPs) from a university student sample. Here we sought to replicate the schema, and use it to explore processing in well-functioning older adults. Methods:We compared behavioural responding and ERPs of 20 independent-living older adults (M age = 68.2 years) to data from a sex-and handedness-matched group of university students (M age = 20.4 years). ERPs had substantial latency differences between the groups, and hence were subjected to separate group temporal PCAs.Results: Component latencies were systematically increased in the older group by some 26 %, with no significant increase in RT or error rates. Despite some differences in their identified components, each group displayed differential component responsivity to Go versus NoGo; this was reduced in the older participants. Conclusion:The results support our processing schema, and provide insight into the processing stages in well-functioning older adults.Significance: Understanding the perceptual and cognitive processing stages in normal ageing is a pre-requisite for research on mild cognitive impairment a...

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“…This is called the reduction or decline of frontal inhibitory control, due to an ineffective top-down modulation of primary auditory responses by prefrontal cortex (Hasher and Zacks 1988;Č eponien_ e et al 2008; for neuro-anatomical evidence see Raz et al 1997;Chao and Knight, 1997b;Dustman et al 1996;Kok 1999). In addition, it has been recently found that aging is related with a decrease in event-related spectral power activity, a low phase locking in N1 theta (4-7 Hz) band over the parietal/frontal regions and with a decrease of functional connections in the alpha Development of the N1 and N2 components 123 (7-13 Hz) and beta (13-30 Hz) bands (Ho et al 2012); this might indicate a higher neuroplasticity of younger brains and easy engagement of attentional resources. Lastly, if we consider and combine results on P3 amplitude decrement and topography change to two distinct foci of activity over age and neuropsychological deficits pointed by several studies, it may be concluded that aging is associated with a general difficulty to distinguish relevant stimulation from irrelevant stimuli, in other words difficulties in selection, categorization and storing in working memory (Picton et al 1984;Iragui et al 1993;Lembreghts et al 1995;Friedman et al 1997;Amenedo and Díaz 1998;Polich 2007;Martin et al 2008).…”

mentioning

confidence: 99%

The development of the N1 and N2 components in auditory oddball paradigms: a systematic review with narrative analysis and suggested normative values

et al. 2014

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Auditory event-related potentials (AERPs) are widely used in diverse fields of today's neuroscience, concerning auditory processing, speech perception, language acquisition, neurodevelopment, attention and cognition in normal aging, gender, developmental, neurologic and psychiatric disorders. However, its transposition to clinical practice has remained minimal. Mainly due to scarce literature on normative data across age, wide spectrum of results, variety of auditory stimuli used and to different neuropsychological meanings of AERPs components between authors. One of the most prominent AERP components studied in last decades was N1, which reflects auditory detection and discrimination. Subsequently, N2 indicates attention allocation and phonological analysis. The simultaneous analysis of N1 and N2 elicited by feasible novelty experimental paradigms, such as auditory oddball, seems an objective method to assess central auditory processing. The aim of this systematic review was to bring forward normative values for auditory oddball N1 and N2 components across age. EBSCO, PubMed, Web of Knowledge and Google Scholar were systematically searched for studies that elicited N1 and/or N2 by auditory oddball paradigm. A total of 2,764 papers were initially identified in the database, of which 19 resulted from hand search and additional references, between 1988 and 2013, last 25 years. A final total of 68 studies met the eligibility criteria with a total of 2,406 participants from control groups for N1 (age range 6.6-85 years; mean 34.42) and 1,507 for N2 (age range 9-85 years; mean 36.13). Polynomial regression analysis revealed that N1 latency decreases with aging at Fz and Cz, N1 amplitude at Cz decreases from childhood to adolescence and stabilizes after 30-40 years and at Fz the decrement finishes by 60 years and highly increases after this age. Regarding N2, latency did not covary with age but amplitude showed a significant decrement for both Cz and Fz. Results suggested reliable normative values for Cz and Fz electrode locations; however, changes in brain development and components topography over age should be considered in clinical practice.

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Age-related changes of task-specific brain activity in normal aging

Cited by 34 publications

References 24 publications

Stability of Auditory Discrimination and Novelty Processing in Physiological Aging

Stability of Auditory Discrimination and Novelty Processing in Physiological Aging

Sequential processing in young and older adults in the equiprobable auditory Go/NoGo task

The development of the N1 and N2 components in auditory oddball paradigms: a systematic review with narrative analysis and suggested normative values

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