Age-Related Changes of the Human Crystalline Lens on High-Spatial Resolution Three-Dimensional T1-Weighted Brain Magnetic Resonance Images In Vivo

Streckenbach, Felix; Stachs, Oliver; Langner, Sönke; Guthoff, Rudolf; Meinel, Felix G.; Weber, Marc‐André; Stahnke, Thomas; Beller, Ebba

doi:10.1167/iovs.61.14.7

Cited by 3 publications

(3 citation statements)

References 49 publications

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“…Here we chose not to perform any additional intensity normalization on the final T1w/T2w myelin maps, since previously proposed methods ( Ganzetti et al, 2014 ; Misaki et al, 2015 ) utilized intensity values of specific ROIs that may introduce confounding age effects. For instance, the T1w MPRAGE signal intensity of the eyeball (vitreous body), which is one of the reference regions used in Ganzetti et al (2014) , has been shown to significantly increase with age ( Streckenbach et al, 2020 ).…”

Section: Methodsmentioning

confidence: 99%

Cortical myelin profile variations in healthy aging brain: A T1w/T2w ratio study

et al. 2022

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Section: Methodsmentioning

confidence: 99%

Cortical myelin profile variations in healthy aging brain: A T1w/T2w ratio study

et al. 2022

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“…If the whole brain is likely to be affected, following the suggestions by Ganzetti et al [ 14 ] and using extracerebral reference regions presents an attractive alternative. However, we must emphasize that even extracerebral structures can be affected by the state under examination, as elaborated for glioblastoma, multiple sclerosis, and aging in previous publications [ 51 – 53 ], and should therefore be selected with care. Future studies should analyze the effect of the biological factors, such as age or the disease under examination, on the reference region before applying intensity scaling.…”

Section: Discussionmentioning

confidence: 99%

“…for glioblastoma, multiple sclerosis, and aging in previous publications [51][52][53], and should therefore be selected with care. Future studies should analyze the effect of the biological factors, such as age or the disease under examination, on the reference region before applying intensity scaling.…”

Section: Plos Onementioning

confidence: 99%

Intensity scaling of conventional brain magnetic resonance images avoiding cerebral reference regions: A systematic review

Wiltgen,

Voon,

Van Leemput

et al. 2024

PLoS ONE

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Background Conventional brain magnetic resonance imaging (MRI) produces image intensities that have an arbitrary scale, hampering quantification. Intensity scaling aims to overcome this shortfall. As neurodegenerative and inflammatory disorders may affect all brain compartments, reference regions within the brain may be misleading. Here we summarize approaches for intensity scaling of conventional T1-weighted (w) and T2w brain MRI avoiding reference regions within the brain. Methods Literature was searched in the databases of Scopus, PubMed, and Web of Science. We included only studies that avoided reference regions within the brain for intensity scaling and provided validating evidence, which we divided into four categories: 1) comparative variance reduction, 2) comparative correlation with clinical parameters, 3) relation to quantitative imaging, or 4) relation to histology. Results Of the 3825 studies screened, 24 fulfilled the inclusion criteria. Three studies used scaled T1w images, 2 scaled T2w images, and 21 T1w/T2w-ratio calculation (with double counts). A robust reduction in variance was reported. Twenty studies investigated the relation of scaled intensities to different types of quantitative imaging. Statistically significant correlations with clinical or demographic data were reported in 8 studies. Four studies reporting the relation to histology gave no clear picture of the main signal driver of conventional T1w and T2w MRI sequences. Conclusions T1w/T2w-ratio calculation was applied most often. Variance reduction and correlations with other measures suggest a biologically meaningful signal harmonization. However, there are open methodological questions and uncertainty on its biological underpinning. Validation evidence on other scaling methods is even sparser.

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Lens Diameter, Anterior Chamber Depth, and Vitreous Depth in Adult Patients: A Nigerian Study

Abadom,

Ominde,

Ikubor

et al. 2024

Nigerian Journal of Basic and Clinical Sciences

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Context: The awareness of the diversity of ocular biometry is vital in the management of glaucoma and pathologies of the lens. Aim: To establish the normal globe biometric parameters of adults in Delta State, Nigeria. Setting and Design: An observational retrospective cross-sectional study at the Radiology Department of Teaching Hospital in Delta State. A purposive sampling technique was adopted. Materials and Methods: After obtaining ethical approval, ocular biometry was conducted on 150 adult brain MRI scans (75 males and 75 females) using a digital caliper. Statistical Analysis Used: The data were analyzed and summarized in descriptive statistics. Inferential statistics were employed for comparison across gender, side, and age groups, as well as to determine the association between variables. A significance level of 5% was adopted. Results: The anterior chamber depth (ACD), vitreous depth, superoinferior (SI), and anteroposterior (AP) lens diameters were symmetrical. All the parameters lacked sexual dimorphism, while the AP and SI lens diameters significantly varied between the 10 year’s age groups (P < 0.05). Age had a significant positive correlation with the AP and SI lens diameters and a negative association with ACD and vitreous length. The vitreous length had a significant positive link with the ACD and SI lens diameter (P < 0.05). The AP lens diameter had a significant negative correlation with ACD and vitreous length (P < 0.05). Conclusion: The normal ocular biometry obtained can be used within the studied population to help in the diagnosis of ocular conditions, management of cataracts, and the design of intraocular lenses.

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Age-Related Changes of the Human Crystalline Lens on High-Spatial Resolution Three-Dimensional T1-Weighted Brain Magnetic Resonance Images In Vivo

Abstract: Age-related changes of the human crystalline lens on high-spatial resolution three-dimensional T1-weighted brain magnetic resonance images in vivo.

Cited by 3 publications

References 49 publications

Cortical myelin profile variations in healthy aging brain: A T1w/T2w ratio study

Cortical myelin profile variations in healthy aging brain: A T1w/T2w ratio study

Intensity scaling of conventional brain magnetic resonance images avoiding cerebral reference regions: A systematic review

Lens Diameter, Anterior Chamber Depth, and Vitreous Depth in Adult Patients: A Nigerian Study

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