2023
DOI: 10.1016/j.imlet.2023.04.003
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Age-related changes of the human splenic marginal zone B cell compartment

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Cited by 3 publications
(3 citation statements)
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“…BCR repertoire deep sequencing analyses point to the existence of a body-wide clonal network, which interconnects sMZ B cells with memory B-cell clone members in distant lymphoid organs and supports the view that human sMZ B cells can undergo subsequent GC reactions and recirculate to distant organs via the blood stream (88,(162)(163)(164). It was also observed that many circulating memory B cells are clonally related to sMZ B cells, supporting the idea of a systematic memory B-cell archive in the spleen (134).…”
Section: Splenic Marginal Zone B Cellssupporting
confidence: 60%
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“…BCR repertoire deep sequencing analyses point to the existence of a body-wide clonal network, which interconnects sMZ B cells with memory B-cell clone members in distant lymphoid organs and supports the view that human sMZ B cells can undergo subsequent GC reactions and recirculate to distant organs via the blood stream (88,(162)(163)(164). It was also observed that many circulating memory B cells are clonally related to sMZ B cells, supporting the idea of a systematic memory B-cell archive in the spleen (134).…”
Section: Splenic Marginal Zone B Cellssupporting
confidence: 60%
“…In order to fulfill their important function in the first line of defense against pathogens invading the bloodstream, sMZ B cells require additional signals from bystander cells in their microenvironment (134,135). Multiple studies have provided insight into the crosstalk among human sMZ B cells and innate immune cells, such as dendritic cells, natural killer cells, neutrophils, and several types of stromal cells (136)(137)(138)(139)(140)(141)(142).…”
Section: Splenic Marginal Zone B Cellsmentioning
confidence: 99%
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