Age-Related Characteristics of Covid-19 Courses in Inpatiens of Emdical Settings in Poltava Region

Abstract

The investigation of factors that may affect the severity of coronavirus infection and mortality has been one of the main areas of medical research. At the present stage, among the possible risk factors of severe COVID-19 course there is the influence of age as a predictor of disease progression in inpatient. Objective: to determine the clinical and laboratory characteristics of the course of coronavirus disease COVID-19 depending on the age of hospitalized patients in Poltava region. Materials and methods: a retrospective cohort follow-up study was conducted involving 150 patients with a laboratory-confirmed diagnosis of "Acute respiratory disease COVID-19" at the Poltava Regional Clinical Infectious Diseases Hospital. Patients were divided into 2 age groups: 60 to 95 years and 18 to 59 years Statistical processing was carried out using SPSS Statistics 25.0 software. Results and conclusions: the study has found that the clinical and laboratory characteristics of the course of coronavirus disease COVID-19 are typical except for some features: hospitalized patients over 60 years were significantly more likely to have severe (p = 0.037) and critical (p = 0.063) course of the disease, require oxygen support (p = 0.001), in particular using low oxygen flows (p = 0.027). Leukocytosis was diagnosed 3.4 times more often in patients older than 60 years (p = 0.032), while leukopenia (p = 0.022) and thrombocytopenia were 2.2 times more often in people younger than 60 years. 0.0041). Severe disease was significantly more common in hospitalized women under 60 years of age than in men of the same age (p = 0.046).