Age-related clonal haemopoiesis is associated with increased epigenetic age

Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction

“…Although age is the predominant factor that contributes to the development of clonal hematopoiesis, these data raise the possibility that clonal hematopoiesis can, in turn, affect the processes that promote biological aging. A recent study associated clonal hematopoiesis with age acceleration through the examination of the "epigenetic clock" that assesses the methylation patterns at specific CpG sites (42). In longitudinal analyses of 2 cohorts, clonal hematopoiesis was found to be associated with 3.7 and 4.5 years of accelerated age, and individuals with TET2-mediated clonal hematopoiesis displayed the greatest accelerations of epigenetic aging (6.1 and 6.4 years) compared with those individuals with no detectable clonal hematopoiesis.…”

The role of clonal haematopoiesis in cardiovascular diseases: epidemiology and experimental studies

“…Whilst this study only focused on cardiac dysfunction in ageing mice, it raises the possibility that clonal haematopoiesis can generally impact the processes that promote biological ageing and diminish health span. It has recently been reported that clonal haematopoiesis is associated with accelerated biological ageing based upon measurements of the 'epigenetic clock' that assesses the methylation patterns at specific CpG sites [53]. Although preliminary, the work of Wang et al [52] provides evidence of a potential causal link between clonal haematopoiesis and the pace of biological ageing.…”

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

“…removing) estimates of blood cell composition. An increasing literature supports the view that IEAA relates to properties of hematopoietic stem cells [8,2,14]. The second generation of epigenetic clocks move beyond estimating chronological age by incorporating information on morbidity and mortality risk (e.g., smoking, plasma protein levels, white blood cell counts), and chronological age.…”