Age-related cytokine effects on cancer-related fatigue and quality of life in acute myeloid leukemia

Alibhai, Shabbir M.H.; Breunis, Henriette; Matelski, John; Timilshina, Narhari; Kundra, Arjun; Lee, Chieh-Hsin; Li, Madeline

doi:10.1016/j.jgo.2019.04.009

Cited by 7 publications

(7 citation statements)

References 54 publications

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“…However, others ( Agasi-Idenburg et al, 2017 ) found no age-related differences in the number and types of symptom clusters identified. In contrast, in a study that explored markers of inflammation ( Alibhai S. M. H. et al, 2020 ), larger associations were found between fatigue severity and plasma levels of 31 cytokines in older patients with leukemia.…”

Section: Introductionmentioning

confidence: 73%

Differences in Circulating Extracellular Vesicle and Soluble Cytokines in Older Versus Younger Breast Cancer Patients With Distinct Symptom Profiles

et al. 2022

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Because extracellular vesicle (EV)-associated cytokines, both encapsulated and surface bound, have been associated with symptom severity, and may vary over the lifespan, they may be potential biomarkers to uncover underlying mechanisms of various conditions. This study evaluated the associations of soluble and EV-associated cytokine concentrations with distinct symptom profiles reported by 290 women with breast cancer prior to surgery. Patients were classified into older (≥60 years, n = 93) and younger (< 60 years, n = 197) cohorts within two previously identified distinct symptom severity profiles, that included pain, depressive symptoms, sleep disturbance, and fatigue (i.e., High Fatigue Low Pain and All Low). EVs were extracted using ExoQuick. Cytokine concentrations were determined using Luminex multiplex assay. Mann Whitney U test evaluated the differences in EV and soluble cytokine levels between symptom classes and between and within the older and younger cohorts adjusting for Karnofsky Performance Status (KPS) score, body mass index (BMI), and stage of disease. Partial correlation analyses were run between symptom severity scores and cytokine concentrations. Results of this study suggest that levels of cytokine concentrations differ between EV and soluble fractions. Several EV and soluble pro-inflammatory cytokines had positive associations with depressive symptoms and fatigue within both age cohorts and symptom profiles. In addition, in the older cohort with High Fatigue Low Pain symptom profile, EV GM-CSF concentrations were higher compared to the All Low symptom profile (p < 0.05). Albeit limited by a small sample size, these exploratory analyses provide new information on the association between cytokines and symptom profiles of older and younger cohorts. Of note, unique EV-associated cytokines were found in older patients and in specific symptom classes. These results suggest that EVs may be potential biomarker discovery tools. Understanding the mechanisms that underlie distinct symptom class profiles categorized by age may inform intervention trials and offer precision medicine approaches.

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Section: Introductionmentioning

confidence: 73%

Differences in Circulating Extracellular Vesicle and Soluble Cytokines in Older Versus Younger Breast Cancer Patients With Distinct Symptom Profiles

et al. 2022

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“…This model posits that behavioral symptoms of illness, such as fatigue, may be determined by sickness-associated inflammation and cytokine activity [ 32 ]. However, a recent study of more than 200 patients with AML concluded that cytokines explained only a small amount of the variance in cancer-related fatigue [ 12 ]. In recent years, advances in the use of genomic sequencing have allowed researchers and clinicians to determine how specific molecular mutations relate to outcomes among patients with AML [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…Given fatigue's prevalence and persistence, researchers have attempted to identify factors that predict fatigue in patients with AML, including sociodemographic characteristics, clinical characteristics 8 and biological factors (eg, proinflammatory cytokines). [9][10][11][12] However, previous studies have not distinguished patients with AML by NCCN risk categories, possibly due to small sample sizes limiting the statistical power to do so. Further characterisation of fatigue among subgroups of patients with AML using common clinical categorisations will provide important information about variations in the burden of fatigue in this patient population.…”

Section: Original Researchmentioning

confidence: 99%

“…32 However, a recent study of more than 200 patients with AML concluded that cytokines explained only a small amount of the variance in cancer-related fatigue. 12 In recent years, advances in the use of genomic sequencing have allowed researchers and clinicians to determine how specific molecular mutations relate to outcomes among patients with AML. 33 Yet, until now, no studies have investigated how molecular mutations relate to fatigue in this population.…”

Section: Original Researchmentioning

confidence: 99%

“…Given fatigue’s prevalence and persistence, researchers have attempted to identify factors that predict fatigue in patients with AML, including sociodemographic characteristics, clinical characteristics [ 8 ], and biological factors (e.g., pro-inflammatory cytokines) [ 9 – 12 ]. However, past studies have not distinguished patients with AML by NCCN risk categories, possibly due to small sample sizes limiting the statistical power to do so.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fatigue in newly diagnosed acute myeloid leukaemia: general population comparison and predictive factors

Oswald

Venditti

Cella

et al. 2021

BMJ Support Palliat Care

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ObjectivesThis study compared the burden of fatigue between treatment-naïve patients with newly diagnosed acute myeloid leukaemia (AML) and the general population and investigated patient factors associated with fatigue severity.MethodsPretreatment patient-reported fatigue was assessed with the Functional Assessment of Chronic Illness Therapy-Fatigue questionnaire in a sample of 463 newly diagnosed patients with AML who were enrolled in a clinical trial. Multivariable linear regression models were used to estimate the adjusted mean differences in fatigue between patients with AML and adults from the general population (n=847) by AML disease risk categories. A clinically meaningful difference in fatigue was defined as ≥3 points. Univariable and multivariable linear regression models were used to identify sociodemographic, clinical and molecular correlates of worse fatigue in patients with AML.ResultsPatients with AML reported adjusted mean fatigue scores that were 7.5 points worse than the general population (95% CI −8.6 to −6.4, p<0.001). Across AML disease risk categories, adjusted mean differences in fatigue compared with the general population ranged from 6.7 points worse (patients with favourable risk: 95% CI −8.6 to −4.8, p<0.001) to 8.9 points worse (patients with poor risk, 95% CI −10.5 to −7.2, p<0.001). Overall, 91% of patients with AML reported fatigue that was equal to or worse than the general population’s median fatigue score. Higher pretreatment fatigue was independently associated with female sex, WHO performance status ≥1 and lower platelet levels.ConclusionsPatients with newly diagnosed AML reported worse fatigue than the general population, and mean differences exceeded twice the threshold for clinical significance. Our findings may help to identify patients with AML most likely to benefit from supportive care interventions to reduce fatigue.

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Exploring the role of health-related quality of life measures in predictive modelling for oncology: a systematic review

van der Heijden,

de Ligt,

Hubel

et al. 2024

Qual Life Res

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Age-related cytokine effects on cancer-related fatigue and quality of life in acute myeloid leukemia

Cited by 7 publications

References 54 publications

Differences in Circulating Extracellular Vesicle and Soluble Cytokines in Older Versus Younger Breast Cancer Patients With Distinct Symptom Profiles

Differences in Circulating Extracellular Vesicle and Soluble Cytokines in Older Versus Younger Breast Cancer Patients With Distinct Symptom Profiles

Fatigue in newly diagnosed acute myeloid leukaemia: general population comparison and predictive factors

Exploring the role of health-related quality of life measures in predictive modelling for oncology: a systematic review

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