Age‐related decline in cortical inhibitory tone strengthens motor memory

Petitet, Pierre; Spitz, Gershon; Emir, Uzay E.; Johansen‐Berg, Heidi; O’Shea, Jacinta

doi:10.1016/j.neuroimage.2021.118681

Cited by 7 publications

(3 citation statements)

References 130 publications

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“…Supporting the previously reported complex re-organization of the excitation/inhibition balance during aging 70 , we find the group-level aging effects on brain function to be associated with glutamatergic and GABAergic neurotransmission. The additional co-localization of the aging effects with monoaminergic and cholinergic systems may be supportive of the underlying changes to be related to learning, memory, and other higher cognitive functions affected by aging 7,15,67,71 .…”

Section: Discussionsupporting

confidence: 88%

Resting state changes in aging and Parkinson’s disease are shaped by underlying neurotransmission – a normative modeling study

Kasper,

Caspers,

Lotter

et al. 2023

Preprint

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Human healthy and pathological aging is linked to a steady decline in brain resting state activity and connectivity measures. The neurophysiological mechanisms underlying these changes remain poorly understood. Making use of recent developments in normative modeling and availability of in vivo maps for various neurochemical systems, we test in the UK Biobank cohort (N=25,917) if and how age- and Parkinson's disease related resting state changes in commonly applied local and global activity and connectivity measures co-localize with underlying neurotransmitter systems. We find the distributions of several major neurotransmitter systems including serotonergic, dopaminergic, noradrenergic and glutamatergic neurotransmission to explain age-related changes as observed across functional activity and connectivity measures. Co-localization patterns in Parkinson's disease deviate from normative aging trajectories for these, as well as for cholinergic and GABAergic neurotransmission. The deviation from normal co-localization of brain function and GABAa correlates with disease duration. These findings provide new insights into molecular mechanisms underlying age- and Parkinson's related brain functional changes. Combining normative modeling and neurotransmitter mapping may aid future research and drug development through deeper understanding of neurophysiological mechanisms underlying specific clinical conditions.

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Section: Discussionsupporting

confidence: 88%

Resting state changes in aging and Parkinson’s disease are shaped by underlying neurotransmission – a normative modeling study

Kasper,

Caspers,

Lotter

et al. 2023

Preprint

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“…In addition, to confirm that the associations between OD thresholds and scores in personality traits were not driven by other possible factors such as age, which has been linked to cortical E-I balance in previous studies (Abuleil, McCulloch and Thompson, 2019;King et al, 2020;Petitet et al, 2021;Pitchaiuthu Bin Dawood, A., Dickinson, A., & Jones, M. (2023). Investigation of the relationship between orientation discrimination thresholds, autistic, and schizotypal personality traits, International Journal of Cognitive Research in Science, Engineering and Education (IJCRSEE), 11(3), 375-387. et al, 2017), further correlation analyses were performed.…”

Section: Resultsmentioning

confidence: 63%

Investigation of the Relationship Between Orientation Discrimination Thresholds, Autistic, and Schizotypal Personality Traits

Bin Dawood,

Dickinson,

Jones

2023

IJCRSEE

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Imbalances in cortical excitation and inhibition (E-I) have been implicated in both autism spectrum conditions (ASC) and schizophrenia spectrum conditions (SSC). However, most studies investigate these clinical conditions independently, possibly due to the difficulty of obtaining comorbid clinical populations. As such, the current study investigated the relationship between performance in the orientation discrimination task “ODT” as a potential proxy for E-I balance and the autistic (as assessed by Autism Spectrum Quotient “AQ”) and schizotypal personality traits (as assessed by Schizotypal Personality Questionnaire-Brief “SPQ-BR”) in the general population. 87 healthy adult volunteers participated in the study. We found that high autistic personality traits are associated with enhanced performance in the oblique condition of ODT. In contrast, high schizotypal personality traits are associated with poor performance in the vertical condition of ODT. Such associations support the suggested disruption of cortical E-I balance in ASC and SSC.

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“…Physiological aging induces changes in the human motor cortex, including cortical atrophy, impaired excitability, and decreased neurotransmitter levels [15,16,73,74]. Generally, cortical atrophy in physiological aging is considered to be due to structural changes in individual neurons, such as shrinkage in the soma size, a reduction in the dendrite arborization complexity and length, and a loss or regression of dendritic spines but not a decrease in cell number [75].…”

Section: Structural and Functional Alteration In The Motor Cortexmentioning

confidence: 99%

Neuronal Plasticity and Age-Related Functional Decline in the Motor Cortex

Inoue,

Nishimune

2023

Cells

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Physiological aging causes a decline of motor function due to impairment of motor cortex function, losses of motor neurons and neuromuscular junctions, sarcopenia, and frailty. There is increasing evidence suggesting that the changes in motor function start earlier in the middle-aged stage. The mechanism underlining the middle-aged decline in motor function seems to relate to the central nervous system rather than the peripheral neuromuscular system. The motor cortex is one of the responsible central nervous systems for coordinating and learning motor functions. The neuronal circuits in the motor cortex show plasticity in response to motor learning, including LTP. This motor cortex plasticity seems important for the intervention method mechanisms that revert the age-related decline of motor function. This review will focus on recent findings on the role of plasticity in the motor cortex for motor function and age-related changes. The review will also introduce our recent identification of an age-related decline of neuronal activity in the primary motor cortex of middle-aged mice using electrophysiological recordings of brain slices.

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Age‐related decline in cortical inhibitory tone strengthens motor memory

Cited by 7 publications

References 130 publications

Resting state changes in aging and Parkinson’s disease are shaped by underlying neurotransmission – a normative modeling study

Resting state changes in aging and Parkinson’s disease are shaped by underlying neurotransmission – a normative modeling study

Investigation of the Relationship Between Orientation Discrimination Thresholds, Autistic, and Schizotypal Personality Traits

Neuronal Plasticity and Age-Related Functional Decline in the Motor Cortex

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