Age-related deficit of androgens in the male patients presenting with coronary heart disease

Abstract

A total of 51 men at a mean age of 55±5.2 years with coronary heart disease were available for examination. Twenty of them presented with confirmed age-related androgen deficiency while the remaining 31 had the testosterone level within the normal reference values. The study included characteristic of lipid and carbohydrate metabolism, diagnosis of obesity and its type, estimation of the depression level, echocardiographic imaging, 24-hour ECG monitoring, and myocardial perfusion scintigraphy. The patients with androgen deficiency were shown to more frequently suffer abdominal obesity and high-level depression than those with the normal testosterone level. Moreover, patients of the former group usually had atypical anginal syndrome. The deficit of androgens was not infrequently associated with a rise in the number of ventricular extrasystoles. The correlation analysis demonstrated a significant negative relationship between the total testosterone level, blood glucose and triglyceride levels, the duration of ST segment ischemic depression.