Age-related differences between thinning of horizontal and vertical trabeculae in human lumbar bone as assessed by a new computerized method

Thomsen, Jens Peter Frølund; Ebbesen, E.N.; Mosekilde, Lis

doi:10.1016/s8756-3282(02)00801-3

Cited by 98 publications

(82 citation statements)

References 27 publications

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“…Vertebral trabecular Conn.D decreases significantly with advancing age. Agedependent change of Conn.D is almost identical for males and females [25,28] . Determination of BMD locally is achievable using QCT owing to its high spatial resolution.…”

Section: Vertebramentioning

confidence: 86%

“…Cancellous connectivity density (Conn. D) is a basic characteristic of 3D network and is critical for the preservation of bone strength. When the amount of cancellous bone declines, the value of Conn.D would decrease correspondently, perhaps attributable to the small trabecular bone loss [25,26,28] . Vertebral trabecular Conn.D decreases significantly with advancing age.…”

Section: Vertebramentioning

confidence: 99%

“…The decrease of spinal cancellous bone with advancing age is predominantly through trabecular perforation rather than trabecular general thinning [25,28] . It is demonstrated that osteoclasts resorb some perforated trabecular bone and the trabecular connectivity is destroyed.…”

Section: Vertebramentioning

confidence: 99%

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Bone three-dimensional microstructural features of the common osteoporotic fracture sites

Chen

Kubo

2014

WJO

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Osteoporosis is a common metabolic skeletal disorder characterized by decreased bone mass and deteriorated bone structure, leading to increased susceptibility to fractures. With aging population, osteoporotic fractures are of global health and socioeconomic importance. The three-dimensional microstructural information of the common osteoporosis-related fracture sites, including vertebra, femoral neck and distal radius, is a key for fully understanding osteoporosis pathogenesis and predicting the fracture risk. Low vertebral bone mineral density (BMD) is correlated with increased fracture of the spine. Vertebral BMD decreases from cervical to lumbar spine, with the lowest BMD at the third lumbar vertebra. Trabecular bone mass of the vertebrae is much lower than that of the peripheral bone. Cancellous bone of the vertebral body has a complex heterogeneous three-dimensional microstructure, with lower bone volume in the central and anterior superior regions. Trabecular bone quality is a key element to maintain the vertebral strength. The increased fragility of osteoporotic femoral neck is attributed to low cancellous bone volume and high compact porosity. Compared with age-matched controls, increased cortical porosity is observed at the femoral neck in osteoporotic fracture patients. Distal radius demonstrates spatial inhomogeneous characteristic in cortical microstructure. The medial region of the distal radius displays the highest cortical porosity compared with the lateral, anterior and posterior regions. Bone strength of the distal radius is mainly determined by cortical porosity, which deteriorates with advancing age. Key words: Osteoporosis; Fracture; Microstructure; Trabecular bone; Cortical bone; Vertebra; Femoral neck; Distal radius Core tip: The most common sites of the osteoporotic fractures include the vertebra, femoral neck and distal radius, where the microstructural information is a key for fully understanding osteoporosis pathogenesis and improving the prediction of fracture risk. Vertebral strength is mostly preserved by trabecular bone, which is microstructurally inhomogeneous, with lower bone volume in the central and anterior superior regions. Increased fragility of osteoporotic femoral neck is attributed to low cancellous bone volume and high compact porosity. Distal radius shows significant variations in cortical porosity, which is the major element attributed to bone strength of the distal radius.

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Section: Vertebramentioning

confidence: 86%

Section: Vertebramentioning

confidence: 99%

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Bone three-dimensional microstructural features of the common osteoporotic fracture sites

Chen

Kubo

2014

WJO

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“…It was also proposed that a potential thinning of residual elements could arise from incomplete refilling by osteoblasts of resorption cavities of normal or reduced size [24]. This theory stimulated research in trabecular bone structure related to aging, and different methods were used to investigate the thickness and spacing of trabecular elements [25][26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Age-related changes in trabecular bone microstructures: global and local morphometry

2005

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Introduction: A recently developed method allows investigating trabecular bone on an elemental (rod/plate) level. With this method, it is possible to measure local morphometric parameters such as thickness or orientation directly on the extracted rods and plates. Age-related changes of trabecular microarchitecture can thus be investigated on an elemental level, which may help to improve the understanding of age-related bone failure mechanism as well as the effect of pharmaceutical intervention in the prevention of such fractures. Methods: Autopsies from femoral heads (FH) and lumbar spine (LS) were analyzed by global morphometry. Additionally, the trabecular structures were decomposed into rods and plates for the analysis with local morphometry. These morphometric indices were related to age using an analysis of covariance to test for gender differences and linearity with age. Results: In this study, age-related changes showed no gender but site differences. In LS, rods were thinned in aging and finally vanish from the structure, causing a transformation of the trabecular bone structure to longer and, on average, thicker rods. In FH, changes were expressed by a simultaneous thinning and loss of interconnecting trabeculae and perforation of plates leading to new plates and rods. Results were mostly in agreement with earlier findings using descriptive analysis of the aging process. Conclusion: Here we present for the first time preliminary quantitative evidence of changes in the local microstructure, i.e., individual rods and plates. Nevertheless, the number of samples was too small to make for ready conclusions. We conclude that the combination of local and global morphometry is a useful method for a detailed and quantitative description of age-related changes in bone microstructure.

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“…The components of the slowness vector parallel to the layers, 1 s , and normal to the layers, 3 s , are related by;…”

Section: The Schoenberg Modelmentioning

confidence: 99%

A Review of the State of Art in Applying Biot Theory to Acoustic Propagation through the Bone

Aygun

2014

OALib

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Understanding the propagation of acoustic waves through a liquid-perfused porous solid framework such as cancellous bone is an important pre-requisite to improve the diagnosis of osteoporosis by ultrasound. In order to elucidate the propagation dependence upon the material and structural properties of cancellous bone, several theoretical models have been considered to date, with Biot-based models demonstrating the greatest potential. This paper describes the fundamental basis of these models and reviews their performance.

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Age-related differences between thinning of horizontal and vertical trabeculae in human lumbar bone as assessed by a new computerized method

Cited by 98 publications

References 27 publications

Bone three-dimensional microstructural features of the common osteoporotic fracture sites

Bone three-dimensional microstructural features of the common osteoporotic fracture sites

Age-related changes in trabecular bone microstructures: global and local morphometry

A Review of the State of Art in Applying Biot Theory to Acoustic Propagation through the Bone

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