Age-related differences in corticosterone secretion in female rats

Lo, Ming-Jae; Kau, Mei-Mei; Chen, Jiann‐Jong; Yeh, Jiun-Yih; H, Lin; Wang, Shyi-Wu; Wang, Paulus S.

doi:10.1016/s0026-0495(99)90117-8

Cited by 12 publications

(14 citation statements)

References 48 publications

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“…It is thought that GH is a major regulatory factor of growth in neonatal animals and that the plasma GH levels of rats are high during the neonatal period and then decline with advancing age [36][37][38]. Furthermore, some reports have shown that the basal level of plasma glucocorticoid increases with advancing age [39,40]. Therefore, it is possible that myostatin expression levels are regulated, at least in part, by several hormones, such as glucocorticoid and GH, during the early postnatal period.…”

Section: Discussionmentioning

confidence: 99%

Role of Serum Myostatin during the Lactation Period

Hosoyama

Yamanouchi

Nishihara

2006

Journal of Reproduction and Development

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Abstract. Myostatin, also known as GDF-8 (Growth/Differentiation Factor-8), is a member of the TGF-β superfamily that negatively regulates skeletal muscle mass in mammals. Mutation of the myostatin gene in mice, cattle, and humans causes a massively developed skeletal muscle, characterized by muscle hypertrophy and hyperplasia. Although myostatin is predominantly expressed in skeletal muscle tissue, several recent studies have shown the presence of myostatin protein in blood and suggested a possible role for circulating myostatin in the regulation of skeletal muscle mass. In the present study, we examined changes in the levels of active form myostatin (13 kDa) in serum after birth by Western blot analysis to predict the role of serum myostatin in early postnatal muscle growth in the rat. Interestingly, the amount of active form myostatin in serum increased after birth and then decreased along with ageing after weaning. To clarify the role of increased serum myostatin during the postnatal period, we administrated follistatin, an inhibitor of myostatin activity, into postnatal rats intraperitoneally just after birth. Follistatin-administration during the postnatal period caused selective hypertrophy of type II muscle fibers in the soleus muscle. These results demonstrate that myostatin in serum acts on skeletal muscle and negatively regulates early postnatal muscle growth.

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Section: Discussionmentioning

confidence: 99%

Role of Serum Myostatin during the Lactation Period

Hosoyama

Yamanouchi

Nishihara

2006

Journal of Reproduction and Development

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“…Further studies from our own laboratory have shown that these changes in steroid hormone production and secretion are not a function of reduced ACTH receptors, cAMP production, cAMP phosphodiesterase, steroidogenic enzymes or lipoprotein-mediated cholesterol delivery and the major alteration in the respective cell types occurs distal to cAMP generation [297,298,[303][304][305]. In contrast, several reports from one laboratory, however, suggests that the adrenocortical cells isolated from aged female rats in fact possess an enhanced capacity to secrete corticosterone in response to ACTH stimulation than cells from young or adult animals [306][307][308][309][310]. Finally, there is also evidence for age-related impaired aldosterone secretion by the isolated rat adrenal capsules and glomerulosa cells [311,312].…”

Section: Experimental Animalsmentioning

confidence: 95%

Impact of Aging on Steroid Hormone Biosynthesis and Secretion

Zaidi¹

2013

TOLSJ

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Steroid hormones are lipophilic, low-molecular weight organic compounds all of which are derived from cholesterol. They are primarily synthesized by steroidogenic glands such as gonads (ovary and testis), the adrenal gland and, during pregnancy, by the placental trophoblasts. Limited steroid synthesis also takes place in the brain. Steroid hormones are crucial for the proper functioning of the body. They mediate a wide variety of vital physiological functions, ranging from maintaining normal reproductive function and secondary sexual characteristics, to regulating virtually every metabolic process in the body. Like many age-related endocrine disorders, aging also progressively impacts the tissue-specific synthesis and secretion of steroid hormones. The goal of this review is to summarize the effects of aging on steroid hormone synthesis and secretion by the adrenal gland and gonads of both human and experimental animal models, to describe the potential involvement of excessive oxidative stress in mediating age-related alterations in steroidogenesis, and to discuss the possible underlying mechanisms involved.

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“…The stress sensitivity of the pigs probably is due to the functional insufficiency of the adrenal cortex (8). It is known that one of the factors stimulating the biosynthesis and secretion of glucocorticoids from the adrenal cortex are the estrogens (7).…”

Section: Introductionmentioning

confidence: 99%