Age related differences in diaphragm muscle fiber response to mid/long term controlled mechanical ventilation

Cacciani, Nicola; Ogilvie, Hannah; Larsson, Lars

doi:10.1016/j.exger.2014.06.017

Cited by 13 publications

(18 citation statements)

References 35 publications

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“…Therefore, present study and Sumino et al show the age‐dependent reduction in the contractile force of the EUS in rats. Because reductions in the contractile force have also been reported in the extensor digitorum longus and soleus muscles in aged rats, the observations of the present study support the idea that reduced contractile function of skeletal muscle is a common event in aging.…”

Section: Discussionsupporting

confidence: 87%

Urethral function and histopathology in aged female rats as a stress urinary incontinence model

Yanai-Inamura

Ôhashi

Ishigami

et al. 2017

LUTS

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Section: Discussionsupporting

confidence: 87%

Urethral function and histopathology in aged female rats as a stress urinary incontinence model

Yanai-Inamura

Ôhashi

Ishigami

et al. 2017

LUTS

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“…Direct measurements of diaphragm muscle function in vitro and in situ show that isometric force normalized for cross-sectional area (‘specific force’) is depressed by 15–30% in heart failure [74–76,13,77–79] as well as aging [16,15,14,80,81]. The decrease in isometric force is seen in both twitch and maximal tetanic contractions (e.g., Fig.…”

Section: Intrinsic Diaphragm Muscle Abnormalitiesmentioning

confidence: 99%

“…The diaphragm is the primary inspiratory muscle and, in CHF, abnormalities of the diaphragm occur earlier or to a greater extent than in limb muscles [9–13]. Similarly, aging causes diaphragm abnormalities [14–16,1]. The combined effects of aging and CHF are unclear because experimental models typically address each condition separately.…”

Section: Introductionmentioning

confidence: 99%

Diaphragm abnormalities in heart failure and aging: mechanisms and integration of cardiovascular and respiratory pathophysiology

Kelley

Ferreira

2016

Heart Fail Rev

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Inspiratory function is essential for alveolar ventilation and expulsive behaviors that promote airway clearance (e.g., coughing and sneezing). Current evidence demonstrates that inspiratory dysfunction occurs during healthy aging and is accentuated by chronic heart failure (CHF). This inspiratory dysfunction contributes to key aspects of CHF and aging cardiovascular and pulmonary pathophysiology including: i) impaired airway clearance and predisposition to pneumonia; ii) inability to sustain ventilation during physical activity; iii) shallow breathing pattern that limits alveolar ventilation and gas exchange; and iv) sympathetic activation that causes cardiac arrhythmias and tissue vasoconstriction. The diaphragm is the primary inspiratory muscle, hence, its neuromuscular integrity is a main determinant of the adequacy of inspiratory function. Mechanistic work within animal and cellular models has revealed specific factors that may be responsible for diaphragm neuromuscular abnormalities in CHF and aging. These include phrenic nerve and neuromuscular junction alterations as well as intrinsic myocyte abnormalities, such as changes in the quantity and quality of contractile proteins, accelerated fiber atrophy, and shifts in fiber type distribution. CHF, aging, or CHF in the presence of aging disturbs the dynamics of circulating factors (e.g., cytokines and angiotensin II) and cell signaling involving sphingolipids, reactive oxygen species, and proteolytic pathways, thus leading to the previously listed abnormalities. Exercise-based rehabilitation combined with pharmacological therapies targeting the pathways reviewed herein hold promise to treat diaphragm abnormalities and inspiratory muscle dysfunction in CHF and aging.

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“…Little information is available on the diaphragm function in middle aged rats, particularly for the Sprague Dawley rats, making it difficult to draw specific comparisons to previous research. How-ever, force declines are commonly seen in the diaphragm of senescent (20+ months of age) F344 rats (e.g., Criswell et al 1997;McMullen et al 2011;Cacciani et al 2014), though this finding is not universal (e.g., Lawler et al 1997). Redox modifications are thought to primarily affect muscle contractility by increasing myofibrillar Ca 2+ sensitivity 2015 | Vol.…”

Section: Diaphragm Contractilitymentioning

confidence: 99%

The effects of buthionine sulfoximine treatment on diaphragm contractility and SERCA pump function in adult and middle aged rats

et al. 2015

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This study examined the effects of 10 days of buthionine sulfoximine (BSO) treatment on in vitro contractility and sarcoplasmic reticulum calcium pump (SERCA) expression and function in adult (AD; 6–8 months old) and middle aged (MA; 14–17 months old) rat diaphragm in both the basal state and following fatiguing stimulation. BSO treatment reduced the cellular concentrations of free glutathione (GSH) by >95% and oxidized glutathione (GSSG) by >80% in both age cohorts. GSH content in AD Control diaphragm was 32% higher (P < 0.01) than in MA Control, with no differences in GSSG. The ratio of GSH:GSSG, an indicator of cellular oxidative state, was 34.6 ± 7.4 in MA Control, 52.5 ± 10.1 in AD Control, 10.6 ± 1.7 in MA BSO, and 9.5 ± 1.1 in AD BSO (BSO vs. Control, P < 0.05). Several findings suggest that the effects of BSO treatment are age dependent. AD BSO diaphragm had 26% higher twitch and 28% higher tetanic force (both P < 0.05) than AD Controls, whereas no significant difference existed between the two MA groups. In contrast to our previous work on BSO-treated AD rats, BSO treatment did not influence maximal SERCA ATPase activity in MA rat diaphragm, nor did SERCA2a expression increase in BSO-treated MA diaphragm. Biotinylated iodoacetamide binding to SERCA1a, a specific marker of free cysteine residues, was reduced by 35% (P < 0.05) in AD Control diaphragm following fatiguing stimulation, but was not reduced in any other group. Collectively, these results suggest an important role for redox regulation in both contractility and SERCA function which is influenced by aging.

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Age related differences in diaphragm muscle fiber response to mid/long term controlled mechanical ventilation

Cited by 13 publications

References 35 publications

Urethral function and histopathology in aged female rats as a stress urinary incontinence model

Urethral function and histopathology in aged female rats as a stress urinary incontinence model

Diaphragm abnormalities in heart failure and aging: mechanisms and integration of cardiovascular and respiratory pathophysiology

The effects of buthionine sulfoximine treatment on diaphragm contractility and SERCA pump function in adult and middle aged rats

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