2022
DOI: 10.1101/2022.03.28.486067
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Age-related differences in functional network segregation in the context of sex and reproductive stage

Abstract: Age is accompanied by differences in the organization of functional brain networks, which impact behavior in adulthood. Functional networks tend to become less segregated and more integrated with age. However, sex differences in network segregation declines with age are not well-understood. Further, network segregation in the context of female reproductive stage is relatively understudied, though unmasking such relationships would be informative for elucidating biological mechanisms that contribute to sex-spec… Show more

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Cited by 6 publications
(12 citation statements)
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“…However, females did not exhibit significant associations between progesterone, 17β-estradiol, or testosterone and network segregation. These findings are inconsistent with a recent study of network segregation from our group (23) which demonstrated some differences with reproductive stage, suggesting hormones may play impact network segregation. That is, female reproductive aging is associated with declines in 17β-estradiol and progesterone (10, 42, 52) and Ballard and colleagues (23) demonstrated significant differences between distinct reproductive stages and network segregation (i.e., COTC, DMN, DA, FPTC, and Sa) in females (23).…”
Section: Discussioncontrasting
confidence: 99%
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“…However, females did not exhibit significant associations between progesterone, 17β-estradiol, or testosterone and network segregation. These findings are inconsistent with a recent study of network segregation from our group (23) which demonstrated some differences with reproductive stage, suggesting hormones may play impact network segregation. That is, female reproductive aging is associated with declines in 17β-estradiol and progesterone (10, 42, 52) and Ballard and colleagues (23) demonstrated significant differences between distinct reproductive stages and network segregation (i.e., COTC, DMN, DA, FPTC, and Sa) in females (23).…”
Section: Discussioncontrasting
confidence: 99%
“…These findings are inconsistent with a recent study of network segregation from our group (23) which demonstrated some differences with reproductive stage, suggesting hormones may play impact network segregation. That is, female reproductive aging is associated with declines in 17β-estradiol and progesterone (10, 42, 52) and Ballard and colleagues (23) demonstrated significant differences between distinct reproductive stages and network segregation (i.e., COTC, DMN, DA, FPTC, and Sa) in females (23). Of note, Ballard and colleagues’ findings may be driven by age as they also found linear relationships between age and network segregation in the aforementioned networks (23).…”
Section: Discussioncontrasting
confidence: 99%
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“…Between-network hyperconnectivity may also reflect a compensatory mechanism to reduced efficiency within networks, contributing to the dedifferentiation of large-scale functional organization in older age (Cabeza et al, 2018). In previous work, we found that reductions in functional network segregation with age are sex-specific in nature; relative to males, females drive negative age-segregation associations for the dorsal attention and default mode networks, whereas males show a unique relationship with the somatosensory hand network (Ballard et al, 2022b). Pertinent to the current findings, the dorsal attention and default mode networks are comprised of prefrontal areas that correspond to that of our Crus I-to-DLPFC network, which also displayed female-specific traits.…”
Section: Discussionmentioning
confidence: 85%