Age-related differences in pain sensitivity and regional brain activity evoked by noxious pressure

Cole, Leonie J; Farrell, Michael J.; Gibson, Stephen; Egan, Gary F.

doi:10.1016/j.neurobiolaging.2008.04.012

Cited by 145 publications

(115 citation statements)

References 60 publications

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“…Significant decrease in volume of cortical and subcortical areas involved in the processing of sensory, emotional, and cognitive aspects of the pain experience is described as a common feature in the elderly's brain [24]. Besides, evoked-regional brain activity and both the ascending and the descending pain inhibitory systems are known to be affected by aging [26].…”

Section: Discussionmentioning

confidence: 99%

Tail-flick test response in 3×Tg-AD mice at early and advanced stages of disease

Baeta-Corral

Defrin

Pick

2015

Neuroscience Letters

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Section: Discussionmentioning

confidence: 99%

Tail-flick test response in 3×Tg-AD mice at early and advanced stages of disease

Baeta-Corral

Defrin

Pick

2015

Neuroscience Letters

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“…To date, however, no critical or meta-analytic reviews have summarized the relationship between race and pain coping or attempted to account for the differences observed across studies. Further, few studies [31 & 63 are notable exceptions] have examined the interactions between race and other putatively important demographic variables, such as gender and age, which are known to be independently associated with pain [19;63;73;100]. It is reasonable to speculate that the relationship between race and pain coping differs based on gender and age.…”

Section: Introductionmentioning

confidence: 99%

Differences in Pain Coping Between Black and White Americans: A Meta-Analysis

Meints

Miller

Hirsh

2016

The Journal of Pain

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Compared to White individuals, Black individuals experience greater pain across clinical and experimental modalities. These race differences may be due to differences in pain-related coping. Several studies examined the relationship between race and pain coping; however, no meta-analytic review has summarized this relationship or attempted to account for differences across studies. The goal of this meta-analytic review was to quantify race differences in the overall use of pain coping strategies as well as specific coping strategies. Relevant studies were identified using electronic databases, an ancestry search, and by contacting authors for unpublished data. Of 150 studies identified, 19 met inclusion criteria, resulting in 6489 participants and 123 effect sizes. All of the included studies were conducted in the United States. Mean effect sizes were calculated using a random effects model. Compared to White individuals, Black individuals used pain coping strategies more frequently overall (d=0.25, p<0.01), with the largest differences observed for praying (d=0.70) and catastrophizing (d=0.40). White individuals engaged in task persistence more than Black individuals (d=−0.28). These results suggest that Black individuals use coping strategies more frequently, specifically strategies associated with poorer pain outcomes. Future research should examine the extent to which the use of these strategies mediates race differences in the pain experience. Perspective Results of this meta-analysis examining race differences in pain related coping indicate that, compared to White individuals, Black individuals use coping strategies more frequently, specifically those involving praying and catastrophizing. These differences in coping may help to explain race differences in the pain experience.

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“…14 The threshold for pain may vary based on the type of stimulus (increase with heat, no change with electrical stimulation, decrease with mechanical pressure and ischemia), duration (increase with shorter duration), and location (increase at peripheral or visceral site). 13,15,16 Although pain may not serve as a reliable warning sign of tissue damage in some atypical clinical presentations (cardiac ischemic pain, abdominal pain) because of the increased pain threshold, this finding should not lead to the conclusion that most of the older adult population will not experience pain. 17,18 Rather, the increased pain threshold that accompanies aging may imply that more significant levels of underlying pathologic disorder may be present in older adults who endorse pain.…”

mentioning

confidence: 99%