Age-related differences in symptoms and their interference with quality of life in 903 cancer patients undergoing radiation therapy

Mohile, Supriya G.; Heckler, Charles E.; Fan, Lin; Mustian, Karen M.; Jean‐Pierre, Pascal; Usuki, K.Y.; Sprod, Lisa K.; Janelsins, Michelle Christine; Purnell, Jason Q.; Peppone, Luke Joseph; Palesh, Oxana; Devine, Katie A.; Morrow, Gary R.

doi:10.1016/j.jgo.2011.08.002

Cited by 49 publications

(53 citation statements)

References 26 publications

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“…The most common symptoms reported in these surveys are consistent with what is known from the larger survivorship literature (Farley Short, Bradley, & Yabroff, 2009; Pachman, et al, 2012; Yabroff, Lund, Kepka, & Mariotto, 2011; B.J. Zebrack, 2011): more than half of the 2910 survivors who were included in these analyses reported fatigue (often the most common symptom reported by samples of survivors (e.g., (Barbera, et al, 2010; Becker, Rechis, Kang, & Brown, 2010; Mohile et al, 2011)), cognitive problems, fears of recurrence, problems with grief or identity, emotional distress, problems with body image, and, for those who were in school at their time of diagnosis, concerns about educational goals. The burden of physical, emotional, and practical concerns reported by survey respondents remained consistently high across the 2006 and 2010 surveys, with one exception: employment concerns were more commonly reported among respondents to the 2010 survey.…”

Section: Discussionsupporting

confidence: 79%

Population-Level Trends in Posttreatment Cancer Survivors’ Concerns and Associated Receipt of Care: Results from the 2006 and 2010 LIVESTRONG Surveys

Beckjord

Reynolds

Londen

et al. 2014

Journal of Psychosocial Oncology

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There is a need to better understand the post-treatment concerns of the nearly 14 million cancer survivors alive in the United States today and their receipt of care. Methods Using data from 2910 post-treatment cancer survivors from the 2006 or 2010 LIVESTRONG Surveys, we examined physical, emotional, and practical concerns, receipt of care, and trends in these outcomes at the population level. Results 89% of respondents reported at least one physical concern (67% received associated post-treatment care); 90% reported at least one emotional concern (47% received care); and 45% reported at least one practical concern (36% received care). Female survivors, younger survivors, those who received more intensive treatment, and survivors without health insurance often reported a higher burden of post-treatment concerns though were less likely to have received post-treatment care. Conclusions These results reinforce the importance of post-treatment survivorship and underscore the need for continued progress in meeting the needs of this population. Efforts to increase the availability of survivorship care are extremely important to improve the chances of people affected by cancer living as well as possible in the post-treatment period.

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Section: Discussionsupporting

confidence: 79%

Population-Level Trends in Posttreatment Cancer Survivors’ Concerns and Associated Receipt of Care: Results from the 2006 and 2010 LIVESTRONG Surveys

Beckjord

Reynolds

Londen

et al. 2014

Journal of Psychosocial Oncology

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“…Moreover, increasing age is associated with the risk of multiple comorbidities, which in themselves could be predisposing, precipitating, or perpetuating risk factors for the development of sleep problems even more so than the cancer itself or its treatments 8384 in large studies, older age has rarely been identified as a risk factor for sleep problems and, in fact, younger cancer patients seem to be at higher risk for sleep problems than older cancer patients 7,85. It is unclear why younger patients are at risk for the development of sleep problems during treatment, but it is possible that disease severity, more aggressive treatments, and/or expectations for better health among younger patients are responsible for higher sleep problem rates 7…”

Section: Biological Mechanisms Contributing To Chemotherapy-associatementioning

confidence: 99%

Prevalence, putative mechanisms, and current management of sleep problems during chemotherapy for cancer

Palesh¹,

Peppone²,

Innominato³

et al. 2012

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122

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Sleep problems are highly prevalent in cancer patients undergoing chemotherapy. This article reviews existing evidence on etiology, associated symptoms, and management of sleep problems associated with chemotherapy treatment during cancer. It also discusses limitations and methodological issues of current research. The existing literature suggests that subjectively and objectively measured sleep problems are the highest during the chemotherapy phase of cancer treatments. A possibly involved mechanism reviewed here includes the rise in the circulating proinflammatory cytokines and the associated disruption in circadian rhythm in the development and maintenance of sleep dysregulation in cancer patients during chemotherapy. Various approaches to the management of sleep problems during chemotherapy are discussed with behavioral intervention showing promise. Exercise, including yoga, also appear to be effective and safe at least for subclinical levels of sleep problems in cancer patients. Numerous challenges are associated with conducting research on sleep in cancer patients during chemotherapy treatments and they are discussed in this review. Dedicated intervention trials, methodologically sound and sufficiently powered, are needed to test current and novel treatments of sleep problems in cancer patients receiving chemotherapy. Optimal management of sleep problems in patients with cancer receiving treatment may improve not only the well-being of patients, but also their prognosis given the emerging experimental and clinical evidence suggesting that sleep disruption might adversely impact treatment and recovery from cancer.

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“…In a study of oncology patients undergoing RT [15], sleep disturbance, pain, and distress were significantly less prevalent among older patients compared to younger patients, while shortness of breath was significantly more prevalent among older patients before RT. In another study of newly diagnosed cancer patients [16], age was weakly correlated with ratings of symptom distress ( r = −0.11, p < 0.02) and older patients reported lower levels of symptom distress.…”

Section: Introductionmentioning

confidence: 99%

Differences in the symptom experience of older versus younger oncology outpatients: a cross-sectional study

et al. 2013

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BackgroundMortality rates for cancer are decreasing in patients under 60 and increasing in those over 60 years of age. The reasons for these differences in mortality rates remain poorly understood. One explanation may be that older patients received substandard treatment because of concerns about adverse effects. Given the paucity of research on the multiple dimensions of the symptom experience in older oncology patients, the purpose of this study was to evaluate for differences in ratings of symptom occurrence, severity, frequency, and distress between younger (< 60 years) and older ( ≥ 60 years) adults undergoing cancer treatment. We hypothesized that older patients would have significantly lower ratings on four symptom dimensions.MethodsData from two studies in the United States and one study in Australia were combined to conduct this analysis. All three studies used the MSAS to evaluate the occurrence, severity, frequency, and distress of 32 symptoms.ResultsData from 593 oncology outpatients receiving active treatment for their cancer (i.e., 44.4% were < 60 years and 55.6% were ≥ 60 years of age) were evaluated. Of the 32 MSAS symptoms, after controlling for significant covariates, older patients reported significantly lower occurrence rates for 15 (46.9%) symptoms, lower severity ratings for 6 (18.9%) symptoms, lower frequency ratings for 4 (12.5%) symptoms, and lower distress ratings for 14 (43.8%) symptoms.ConclusionsThis study is the first to evaluate for differences in multiple dimensions of symptom experience in older oncology patients. For almost 50% of the MSAS symptoms, older patients reported significantly lower occurrence rates. While fewer age-related differences were found in ratings of symptom severity, frequency, and distress, a similar pattern was found across all three dimensions. Future research needs to focus on a detailed evaluation of patient and clinical characteristics (i.e., type and dose of treatment) that explain the differences in symptom experience identified in this study.

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Age-related differences in symptoms and their interference with quality of life in 903 cancer patients undergoing radiation therapy

Cited by 49 publications

References 26 publications

Population-Level Trends in Posttreatment Cancer Survivors’ Concerns and Associated Receipt of Care: Results from the 2006 and 2010 LIVESTRONG Surveys

Population-Level Trends in Posttreatment Cancer Survivors’ Concerns and Associated Receipt of Care: Results from the 2006 and 2010 LIVESTRONG Surveys

Prevalence, putative mechanisms, and current management of sleep problems during chemotherapy for cancer

Differences in the symptom experience of older versus younger oncology outpatients: a cross-sectional study

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