Age-Related Differences in the Elasticity of the Human Cornea

Cartwright, Nathaniel E. Knox; Tyrer, John R.; Marshall, John

doi:10.1167/iovs.09-4798

Cited by 161 publications

(102 citation statements)

References 43 publications

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“…30 Additionally, recent studies demonstrate clear dependence of ocular tissue elasticity as a function of age. 35 Therefore, higher velocities measured in corneas of older mice suggest that the elasticity of the cornea is increasing with the age.…”

mentioning

confidence: 98%

In vivoestimation of elastic wave parameters using phase-stabilized swept source optical coherence elastography

et al. 2012

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mentioning

confidence: 98%

In vivoestimation of elastic wave parameters using phase-stabilized swept source optical coherence elastography

et al. 2012

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“…Changes in corneal thickness due to ageing, age-related increase of cataracts that leads to myopic changes, and reduction in corneal curvature can be regarded as some of the reasons behind this condition. Different correlations between choroidal thickness and spherical equivalent in different age groups also occur because of these reasons (22). Min Kim et al's study has shown that there is a significant difference between refraction and choroidal thickness in people below the age of 60 while this correlation is not observed in people older than 60 (23).…”

Section: Discussionmentioning

confidence: 99%

Subfoveal Choroidal Thickness in Relation to Axial Length and Refractive Errors in Adults Aged 20-40

Ekmen¹

2015

J Turgut Ozal Med Cent

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Aim: The aim of this study is to investigate the association between subfoveal choroidal thickness, ocular axial length, and refractive errors in healthy adults. Materials and Methods: A hundred eyes of 50 patients were included in this study. A full ophtalmic examination including best corrected visual acuity, refractive levels, and interferometric ocular axial length was applied to all the patients. The submacular choroidal was imaged using enhanced depth imaging spectral domain optical cohorence tomography. Subfoveal choroidal thickness was measured by two diifferent experts using visual inspection and manual fitting of the choroidal borderlines. Results: Of the 50 subjects, 24 were males and 26 were females. The results of the applied measurements were as follows: mean age: 28,9(±6,8); visual acuity: 0,95±0,16; mean subfoveal choroidal thickness: 302,64μm(±52,07); mean axial lentgh: 23,59mm(±0,94); mean intraoculer pressure 14,5±2,3; and mean spheric equivalent -0,47(±0,97). No significant difference between males and females was observed in terms of mean subfoveal choridal thickness. Multivariable linear regression suggested that age was not associated with subfoveal choroidal thickness (r=-0,247; p=0,106). There was no correlation between axial length and subfoveal choroidal thickness either (r=-0,128; p=0,234). There was, however, a positive correlation between spheric equivalents and subfoveal choroidal thickness (r=0,227; p=0,033). Conclusion: In this study, we found that subfoveal choroidal thickness was significantly associated with spheric equivalent while there was no association between axial length and subfoveal choroidal thickness. We also observed that there was no difference between males and females with regards to subfoveal choroidal thickness.

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“…18 Radial speckle shearing interferometry has been used to show the effect of using different parameters during LASIK surgery such as depth and angles of incisions. 19 It has also been used to determine the changes in Young's modulus of the cornea during ageing 20 and following crosslinking. 21 It is non-contact, nondestructive, provides data in real time, and is highly sensitive; the sensitivity can be optimised so the cornea is loaded at pressures within the physiological range.…”

Section: Laser Interferometrymentioning

confidence: 99%

The role of light in measuring ocular biomechanics

Wilson

Marshall

Tyrer

2016

Eye

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The cornea is a highly specialised tissue with a unique set of biomechanical properties determined by its complex structure. The maintenance of these mechanical properties is fundamental to maintain clear vision as the cornea provides the majority of the focussing power of the eye. Changes to the biomechanics of the cornea can occur during ageing, disease, and trauma, or as a result of surgery. Recently there has been increased interest in the mechanical properties of the cornea as knowledge of these properties has significant implications for the improvement of current ocular treatments including PRK and LASIK, and for the diagnosis and tracking of corneal diseases and therapy such as keratoconus and crosslinking. Biomechanics are also important for the development of artificial corneal replacements. This paper describes the use of a novel, non-destructive lateral electronic speckle pattern shearing interferometer (ESPSI). The data generated via this technique give a full-field view of the mechanical response of the cornea under simulated physiological loading conditions, and enables strain and displacement to be determined in three planes. The technique allows corneal stiffness to be quantified and enables changes and non-homogeneities that occur due to surgery or disease to be detected.

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Age-Related Differences in the Elasticity of the Human Cornea

Cited by 161 publications

References 43 publications

In vivoestimation of elastic wave parameters using phase-stabilized swept source optical coherence elastography

In vivoestimation of elastic wave parameters using phase-stabilized swept source optical coherence elastography

Subfoveal Choroidal Thickness in Relation to Axial Length and Refractive Errors in Adults Aged 20-40

The role of light in measuring ocular biomechanics

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