Age-related differences pre-, intra-, and postcholecystectomy: A retrospective cohort study of 6,868 patients

Maqsood, Hadia; Patel, Kalpesh; Ferdosi, Hamid; Sill, Anne; Wu, Bin; Buddensick, Thomas J.; Sautter, Amanda; Shaukat, Haroon; Sulkowski, Gisela; Narducci, Dusty Marie; Siddique, Mustafa; Kamangar, Farin; Kowdley, Gopal C.; Cunningham, Steven C.

doi:10.1016/j.ijsu.2017.01.046

Cited by 6 publications

(5 citation statements)

References 25 publications

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“…Although LC is considered safe, the rate of morbidity and mortality may be significant in some groups of patients, such as elderly, morbidly obese and immunosuppressed patients 9,17 . LC perioperative morbidity and mortality are usually considered higher in the elderly due to low physiologic reserve and associated diseases [18][19][20][21] . and gallbladder carcinoma [22][23][24] .…”

Section: Discussionmentioning

confidence: 99%

“…The chronological age used to define an elderly or old person ranges in the medical literature from 60 to 80 years 7,9,18,25 . We used the World Health Our findings are also in agreement with previous studies, which have shown that the rate of males, jaundice, prior abdominal operations, and ASA scores II, III, and IV were higher in the elderly than in the younger group 1,8,11,26,27 .…”

Section: Discussionmentioning

confidence: 99%

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Resultado da colecistectomia laparoscópica em idosos.

Coelho

Dalledone

Domingos

et al. 2018

Rev. Col. Bras. Cir.

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RESUMO Objetivo: avaliar os resultados da colecistectomia laparoscópica em idosos comparados com pacientes mais jovens. Métodos: revisamos os prontuários médicos informatizados de todos os pacientes submetidos à colecistectomia laparoscópica para colecistite crônica ou aguda, de 1o de janeiro de 2011 a 31 de março de 2018, em um único hospital de ensino. Os pacientes foram estratificados em dois grupos: idosos (≥60 anos de idade) e mais jovens (<60 anos de idade). Resultados: de 1645 pacientes submetidos à colecistectomia laparoscópica, 1161 (70,3%) eram mais jovens e 484 (29,7%) eram idosos. A taxa de homens foi maior nos idosos (n=185, 38,2%) do que no grupo mais jovem (n=355, 30,6%, p=0,003). Icterícia foi mais comum em idosos do que no grupo mais jovem (p=0,004). A taxa de operação abdominal prévia também foi maior nos idosos (<0,001). A porcentagem de pacientes com escore ASA II, III e IV foi maior no grupo de idosos (p<0,001 no escore II e III e 0,294 no escore IV). O tempo de operação foi maior nos idosos (71,68±31,27) do que no grupo mais jovem (p=0,001). Os seguintes dados perioperatórios foram maiores nos idosos: colecistite aguda (p<0,001), taxa de conversão (p=0,028), complicações pós-operatórias (p=0,042) e mortalidade (p=0,026). Conclusão: o tempo operatório é maior e a taxa de colecistite aguda, conversão para colecistectomia aberta e complicações pós-operatórias são maiores em idosos quando comparados com pacientes mais jovens submetidos à colecistectomia laparoscópica.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Resultado da colecistectomia laparoscópica em idosos.

Coelho

Dalledone

Domingos

et al. 2018

Rev. Col. Bras. Cir.

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“…While some authors have reported age-related pre-, intra- and postcholecystectomy differences, highlighting the fact that the elderly people were predisposed to develop various complications, including PCS, other researchers did not find any clear evidence supporting the idea of high risk for PCS in older age. 54 , 55 The results of the present study have shown that PCS (+) group displayed significantly older age by comparison to those without PCS.…”

Section: Discussionmentioning

confidence: 46%

Dyspepsia and Gut Microbiota in Female Patients with Postcholecystectomy Syndrome

Georgescu¹,

Caraba²,

Ioniță³

et al. 2022

IJWH

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Background Gallstone disease (GSD) represents one of the most frequent digestive disorders, highly reported in female gender. The purpose of the study was to explore the clinical and gut microbiota particularities of female patients with postcholecystectomy syndrome (PCS) and the possible relationship between gut dysbiosis (DB) and abdominal complaints. Patients and Methods In total, 129 female participants: 104 outpatients divided into two equal groups, 52 PCS (+), 52 PCS (−) and 25 healthy controls were consecutively enrolled in this observational study. Patients underwent clinical examination with assessment of pain, bloating, transit disturbances, abdominal ultrasound/computer tomography/magnetic resonance imaging/endoscopic retrograde cholangiopancreatography, upper and lower digestive endoscopies. Laboratory work-ups and stool microbiology assessments were performed for all study participants (patients and controls). Stool microorganisms were identified by matrix-assisted laser desorption ionization – time-of-flight– mass spectrometry and in patients with DB also by next-generation sequencing. Results Older age, complicated gallstones disease, associated conditions like diabetes mellitus/impaired glucose tolerance and irritable bowel syndrome were significantly present in PCS (+) group, as well as sedentary lifestyle and diets characterized by a low fiber intake (p<0.0001). PCS (+) patients displayed significant differences related to the incidence and severity of overall gut microbiota DB, decreased H index of biodiversity and the unbalanced Firmicutes/Bacteroidetes (F/B) ratios by comparison to the PCS (−) group (p<0.0001). Strong positive correlations of the severity of overall DB with bloating and the intestinal habit disorders, as well as of F/B ratios to all abdominal symptoms were noted. Conclusion PCS in female patients was associated with older age, sedentary lifestyle, specific dietary habits, history of complicated gallstone disease, diabetes mellitus/impaired glucose tolerance and irritable bowel syndrome, as well as gut microbiota particularities. Overall DB and unbalanced F/B ratios were strongly correlated to abdominal complaints.

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“…Cholesterol polyps (cholesterolosis) are the most common, benign non-neoplastic, non-inflammatory lesions of the gallbladder 6. The prevalence of cholesterolosis varies from 9% to 26% and cholesterolosis is more likely to be present in young adults 7 8. An association between cholesterolosis and high BMI is found 9.…”

Section: Discussionmentioning

confidence: 99%

Abdominal pain and vomiting during pregnancy due to cholesterolosis

Stirum¹,

Pampus

Jansen

et al. 2019

BMJ Case Rep

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We present a 22-year-old pregnant woman at 15 weeks of gestation, with abdominal pain and vomiting. We demonstrate that diagnosis and treatment of vomiting and abdominal pain in pregnancy can be difficult. Therefore, involvement of other medical specialists is important when common treatments fail. Cholesterolosis can cause symptoms similar to those caused by cholelithiasis. Controversial to gallstones, identification of cholesterolosis by ultrasound is hard. Cholecystectomy is the only effective treatment option for cholesterolosis and can be performed safely during pregnancy. Cholecystectomy in pregnancy should be considered if, despite atypical symptoms, gallbladder disease is suspected and other diagnoses are ruled out. This may reduce recurrent symptoms, hospital admissions, exposure to harmful drugs and obstetric complications.

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Age-related differences pre-, intra-, and postcholecystectomy: A retrospective cohort study of 6,868 patients

Cited by 6 publications

References 25 publications

Resultado da colecistectomia laparoscópica em idosos.

Resultado da colecistectomia laparoscópica em idosos.

Dyspepsia and Gut Microbiota in Female Patients with Postcholecystectomy Syndrome

Abdominal pain and vomiting during pregnancy due to cholesterolosis

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