Age-related distribution of basal serum AMH level in women of reproductive age and a presumably healthy cohort

Shebl, Omar; Ebner, Thomas; Sir, Andreas; Schreier-Lechner, Elisabeth; Mayer, RB; Tews, G; Sommergruber, Michael

doi:10.1016/j.fertnstert.2010.09.012

Cited by 63 publications

(44 citation statements)

References 25 publications

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“…Averages and standard error of the mean (SEM) are shown for each age group a yes means cyclic swelling; no means no swelling; irr means irregular swelling b Lower detection limit was 0.16 mg/ml c % of animals ovulating in the Old group is significantly higher than the % in the Young group. The Middle-aged group does not differ from the other two the present analysis, studies of this hormone in humans (Ledger 2010;Shebl et al 2011) and cynomolgus monkeys (Appt et al 2009) suggest that serum levels of AMH are a good index of the number of oocytes present in the ovary. Further study with a larger number of chimpanzees may confirm this pattern in these apes as well.…”

Section: Discussionmentioning

confidence: 46%

Menopause occurs late in life in the captive chimpanzee (Pan troglodytes)

Herndon

Paredes

Wilson

et al. 2011

AGE

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Menopause in women occurs at mid-life. Chimpanzees, in contrast, continue to display cycles of menstrual bleeding and genital swelling, suggestive of ovulation, until near their maximum life span of about 60 years. Because ovulation was not confirmed hormonally, however, the age at which chimpanzees experience menopause has remained uncertain. In the present study, we provide hormonal data from urine samples collected from 30 female chimpanzees, of which 9 were old (>30 years), including 2 above the age of 50 years. Eight old chimpanzees showed clear endocrine evidence of ovulation, as well as cycles of genital swelling that correlated closely with measured endocrine changes. Endocrine evidence thus confirms prior observations (cyclic anogenital swelling) that menopause is a late-life event in the chimpanzee. We also unexpectedly discovered an idiopathic anovulation in some young and middle-aged chimpanzees; this merits further study. Because our results on old chimpanzees validate the use of anogenital swelling as a surrogate index of ovulation, we were able to combine data on swelling and urinary hormones to provide the first estimates of age-specific rates of menopause in chimpanzees. We conclude that menopause occurs near 50 years of age in chimpanzees as it does in women. Our finding identifies a basic difference between the human and chimpanzee aging processes: female chimpanzees can remain reproductively viable for a greater proportion of their life span than women. Thus, while menopause marks the end of the chimpanzee's life span, women may thrive for decades more.

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Section: Discussionmentioning

confidence: 46%

Menopause occurs late in life in the captive chimpanzee (Pan troglodytes)

Herndon

Paredes

Wilson

et al. 2011

AGE

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“…The main aim of our study was to provide age-specific serum AMH reference values and analyze the distribution of basal serum AMH levels in women of reproductive age. In a retrospective study, Shebl et al [18] evaluated the age-related distribution of basal serum AMH levels in women of reproductive age and concluded that there was wide variation in serum AMH levels in each year of age analyzed, with even young women at risk of reduced ovarian reserves. To the best our knowledge, this is one of the first studies to date to examine age-specific medians, for serum AMH in women undergoing evaluations at Turkish fertility centers.…”

Section: Discussionmentioning

confidence: 99%

Age-Related Distribution of Basal Anti-Mullerian Hormone Levels in a Population of Infertile Women

Özcan¹,

Fıçıcıoğlu²,

Yeşiladalı³

et al. 2016

Ann Clin Anal Med

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ÖzetAmaç: Mevcut araştırmada kadınlarda serum Anti-Müllerian Hormon (AMH) ölçümlerinin yaşa özgü referans değerlerini belirlemek, yaşa özgü beklenen değerlerle ilgili bir referans değeri oluşturmak ve çocuk sahibi olmak amacıy-la infertilite polikliniğine başvuran doğurgan yaştaki Türk kadınlarının bazal serum AMH seviyelerinin dağılımını analiz etmeyi amaçladık. Gereç ve Yön-tem: Türkiye' deki tek bir infertilite merkezine 12 aylık period içinde başvuran 409 kadının siklusun 2-3. gününde prospektif olarak toplanan AMH ölçümleri-nin retrospektif analizi yapılmıştır. Bulgular: Serum AMH konsantrasyonu yaş-la birlikte azalma göstermiştir. Yaş ortalaması 34.04±5.39, serum AMH konsantrasyon ortalaması 1.77±1.82 idi. AMH seviyeleri 20-24, 25-29, 30-34, 35-39, ve >40 yaş gruplarına göre incelendi. Ortanca AMH değerleri belirtilen yaşlara göre sırası ile 2.16 ng/ml, 2.15 ng/ml, 1.71 ng/ml, 0.80 ng/ml ve 0.47 ng/ml'dir. Tartışma: Çalışmada sunulan mevcut veriler Türk infertile kadınlar-da serum AMH konsantrasyonu için bir çerçeve oluşturacaktır. Anahtar KelimelerAnti-Müllerian Hormon; Reprodüktif Yaş; Yaşa Özgü Değerler Concentrations of serum AMH were shown to decrease with advancing age of the female partner. The mean age of the women was 34.04±5.39 years and the mean AMH level of the women was 1.77±1.82. The AMH levels were grouped according to age as follows: 20-24, 25-29, 30-34,35-39, and >40 years. The median AMH values were 2.16 ng/ml, 2.15 ng/ml, 1.71 ng/ml, 0.80 ng/ml, and 0.47 ng/ml, respectively according to the age groups. Discussion:The present data provide a framework for age-specific serum AMH levels in a Turkish population of infertile women.

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“…Nevertheless, anatomopathological evaluation remains an essential tool, yielding an initial analysis of the presence of follicles, as well as the presence or absence of malignant cells. In order to predict ovarian follicular density and help us select the best indications for OTC, a first report on age-related distribution of basal serum AMH levels in women of reproductive age was recently published by Shebl et al [54]. In the near future, OTC indications may be adapted to take age and serum AMH concentrations into account, even if the exact role and involvement of AMH still needs to be elucidated.…”

Section: Histologymentioning

confidence: 99%

A review of 15 years of ovarian tissue bank activities

Dolmans

Jadoul

Gilliaux

et al. 2013

J Assist Reprod Genet

109

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Purpose To review 15 years of activities in ovarian tissue cryobanking from medical database files, including patient indications, histological evaluation and clinical characteristics. Methods Retrospective longitudinal analysis of data from an ovarian tissue bank in an academic hospital. Five hundred and eighty-two patients had their ovarian tissue cryobanked between April 1997 and January 2012. Analysis of cryobanking database: precryopreservation patient characteristics, indications and safety issues, laboratory files and postcryopreservation clinical data. Results Of the 582 patients who had their ovarian tissue cryopreserved, 106 patients donated for research purposes and 476 patients for fertility preservation and long-term cryopreservation. Clinical data analysis of the 476 patients revealed a mean age at the time of cryopreservation of 23± 8.5 years (range: 9 months -39 years), with 96.2 % of subjects aged ≤35 years (n=458). Among 391 cases of malignant disease, hematological malignancies (39.9 %, n=156) and breast cancer (21.7 %, n=85) were the two main indications.At histology, malignant cells were found in ovarian tissue from leukemia patients (n = 3) and non-Hodgkin's lymphoma patients (n=2). Eleven patients underwent autotransplantation, resulting in 5 live births and 1 ongoing pregnancy. Conclusion This is the largest and most comprehensive study to describe and analyze indications and clinical patient characteristics before and after ovarian tissue cryopreservation. The procedure is safe, easy and promising. The database concept is a useful tool in patient selection for autotransplantation.

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Age-related distribution of basal serum AMH level in women of reproductive age and a presumably healthy cohort

Cited by 63 publications

References 25 publications

Menopause occurs late in life in the captive chimpanzee (Pan troglodytes)

Menopause occurs late in life in the captive chimpanzee (Pan troglodytes)

Age-Related Distribution of Basal Anti-Mullerian Hormone Levels in a Population of Infertile Women

A review of 15 years of ovarian tissue bank activities

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