2021
DOI: 10.2478/amb-2021-0007
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Age-Related Dynamics in Post-Vaccine Antibody Immune Response to Diphtheria and Tetanus Toxoid in Bulgarian Subjects

Abstract: In this study, we investigated the age-related dynamics in post-vaccine humoral immunity to diphtheria (DT) and tetanus (TT) toxoids in the Bulgarian population. In addition, we attempted to correlate the titers of specific antibodies with the predisposition to more common infectious pathology among our study participants. The 208 individuals tested were divided into five age groups: 0-4, 4-6, 6-12, 12-17 and 17-66 years, based on the vaccines received according to the immunization schedule in Bulgaria. Vaccin… Show more

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“…We were already successful in using such approaches to identify patients with immune dysfunction. For example, our results from analysis of the post-vaccine immune response against protein antigens (tetanus and diphtheria) among a representative sample of the population showed ( 13 ) that individuals with insufficient titer of antibodies exhibited more frequent infectious and other symptoms and needed to be evaluated for the existence of primary or secondary immune disorders.…”
Section: Discussionmentioning
confidence: 99%
“…We were already successful in using such approaches to identify patients with immune dysfunction. For example, our results from analysis of the post-vaccine immune response against protein antigens (tetanus and diphtheria) among a representative sample of the population showed ( 13 ) that individuals with insufficient titer of antibodies exhibited more frequent infectious and other symptoms and needed to be evaluated for the existence of primary or secondary immune disorders.…”
Section: Discussionmentioning
confidence: 99%