Age-Related Dynamics of Cognitive Functions in Persons Aged 50–85 Years

Vv, Zakharov; Savushkina, I. Yu.; Mkhitaryan, É. A.; Koberskaya, N. N.; Локшина, А. Б.; Grishina, D. A.; Posokhov, C. I.; Tarapovskaya, A. V.; Yakhno, N. N.

doi:10.1134/s2079057018010137

Cited by 6 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…По статистике, от 3 до 20% лиц старше 65 лет имеют тяжелые КН в виде деменции. В большинстве случаев деменции предшествуют недементные КН, не приводящие к утрате независимости в повседневной жизни [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Своевременная диагностика недементных КН расширяет потенциальные возможности лечения, которое может отсрочить (или даже предотвратить) наступление профессиональной и социальной дезадаптации.…”

unclassified

Heterogeneity of the mild cognitive impairment syndrome (specialized outpatient service data analysis)

Локшина

Захаров

Grishina

et al. 2021

RJTAO

Self Cite

View full text Add to dashboard Cite

Timely diagnosis and optimal management of patients with cognitive impairment (CI) without dementia can potentially reduce the risk of their progression to dementia. In our study, we assessed the features of mild CI (MCI) syndrome in patients with neurological disorders based on the specialized outpatient service data analysis.Objective: to analyze clinical, neuropsychological, and neuroimaging characteristics of MCI syndrome in the Russian population in real clinical practice.Patients and methods. We enrolled 515 patients (209 men and 306 women, mean age – 71.2±8.0 years) with memory and/or other cognitive complaints. Seventy healthy volunteers (25 men and 45 women, mean age – 69.5±5.71 years) without cognitive complaints and central nervous system or mental disorders were enrolled in the control group. DSM-V diagnostic criteria for mild neurocognitive disorder were used. Participants underwent comprehensive neuropsychological testing with a qualitative and quantitative assessment of the results. In some of them (29.13%), brain magnetic resonance imaging (MRI) was performed.Results and discussion. The following types of MCI were identified in study participants: monofunctional non-amnestic type (MFNAT) – 1.2%, monofunctional amnestic type (MFAT) – 12.6%, polyfunctional amnestic type (PFAT) – 22.9%, polyfunctional non-amnestic type (PFNAT) – 63.3%. We found a higher prevalence of executive dysfunction and attention deficit in PFNAT, and executive dysfunction, attention deficit, and memory decline in PFAT. Cardiovascular risk factors and signs of vascular leukoencephalopathy on MRI were more frequently observed in PFNAT and PFAT.Conclusion. The clinical and neuropsychological analysis allows us to assume the pathophysiology of CI before the development of dementia. In the Russian population, cerebrovascular insufficiency plays a significant role in the development of MCI syndrome.

show abstract