Age-related effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment of common marmosets

Rose, Sarah; Nomoto, Masahiro; Jackson, E.A.; Gibb, W. R. G.; Jaehnig, Peter; Jenner, Peter; Marsden, C. D.

doi:10.1016/0014-2999(93)90800-w

Cited by 59 publications

(35 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Senescence in marmosets begins around the age of 8-10 years as measured by neuropathology related to Alzheimer's (28) and Parkinson's (29) diseases, hearing loss (30), and cartilage aging (31). Here, we examined whether there is a relationship between age and the number of new cells generated in the dentate gyrus and subventricular zone (SVZ) of adult marmosets 1.5-7 years of age.…”

mentioning

confidence: 99%

Diminished adult neurogenesis in the marmoset brain precedes old age

Leuner

Kozorovitskiy

Gross

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

205

153

View full text Add to dashboard Cite

With aging there is a decline in the number of newly generated neurons in the dentate gyrus of the hippocampus. In rodents and tree shrews, this age-related decrease in neurogenesis is evident long before the animals become aged. No previous studies have investigated whether primates exhibit a similar decline in hippocampal neurogenesis with aging. To investigate this possibility, young to middle aged adult common marmosets (Callithrix jacchus) were injected with BrdU and perfused 3 weeks later. The number of newly generated cells in the subgranular zone/granule cell layer of the dentate gyrus was significantly lower in older animals and decreased linearly with age. A similar age-related decline in new cells was observed in the subventricular zone but not in the hilar region of the dentate gyrus. These data demonstrate that a substantial decrease in neurogenesis occurs before the onset of old age in the adult marmoset brain, suggesting the possibility that similar alterations occur in the human brain.aging ͉ BrdU ͉ dentate gyrus ͉ hippocampus ͉ subventricular zone N ew neurons are continually added to the dentate gyrus of the hippocampus throughout life in several species, from rodents to humans (1-8). Evidence of neurogenesis has been observed in the dentate gyrus even in aged animals, including rodents over 2 years of age (9-14), dogs as old as 15 years (15), and humans as old as 72 years (4). However, substantial reductions in adult neurogenesis occur by old age in rodents and dogs (7,9,(15)(16)(17). In adult rats, mice, and tree shrews, rates of neurogenesis begin to slow by 1 year of age, well before the onset of senescence (9,13,14,16,(18)(19)(20)(21)(22). Some age-associated cognitive deficits first appear in middle aged individuals, considerably before old age (23-25), raising the possibility that reduced neurogenesis may contribute to these problems.There are data suggesting that non-human primates exhibit a similar decrease in neurogenesis with advancing age. We have observed reduced numbers of proliferating cells and immature granule neurons in the dentate gyrus of middle aged (7-16 years) and aged (23 years) macaque monkeys (6). However, the small sample size in that study precluded any systematic analysis of the relationship between age and neurogenesis. Thus, it remains unclear whether neurogenesis in the adult primate brain is sensitive to aging and, moreover, whether the decline in neurogenesis becomes evident before old age. Evidence for an agerelated decrease in neurogenesis in the nonhuman primate brain would suggest that similar alterations may occur in the human brain, where it is more difficult to study (26).The common marmoset (Callithrix jacchus) is a New World monkey that reaches sexual maturity at Ϸ1.5 years of age and has a lifespan that ranges from Ϸ8 to 16 years (27). Senescence in marmosets begins around the age of 8-10 years as measured by neuropathology related to Alzheimer's (28) and Parkinson's (29) diseases, hearing loss (30), and cartilage aging (31). Here, we examined whether...

show abstract

mentioning

confidence: 99%

Diminished adult neurogenesis in the marmoset brain precedes old age

Leuner

Kozorovitskiy

Gross

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

205

153

View full text Add to dashboard Cite

show abstract

“…Degeneration of DA neurons of the nigrostriatal pathway, similar to the one observed in PD, have been reproduced in human and experimental animal models following exposure to MPTP Forno, 1993;Irwin, 1993;Rose, 1993;Ovadia, 1995;Kitamura, 2000;Serra, 2002;Meissner, 2003 andPorras et al, 2012) and in animals following administration of rotenone through multiple routes of exposure (Betabret, 2000(Betabret, , 2006Schmidt, 2002;, Saravanan, 2005Pan-Montojo, 2010;. This indicates that both chemicals can be used as a tool compound for experimental investigations on PD and to explore the key event relationship between impaired proteostasis and degeneration of DA neurons of nigrostriatal pathway.…”

Section: A422 Empirical Support For Linkagementioning

confidence: 83%

“…This indicates that both chemicals can be used as a tool compound for experimental investigations on PD and to explore the key event relationship between impaired proteostasis and degeneration of DA neurons of nigrostriatal pathway. Also, similar to PD, susceptibility to MPTP increases with age in both non-human primates and mice Rose et al, 1993, Ovadia et al, 1995.…”

Section: A422 Empirical Support For Linkagementioning

confidence: 95%

Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson's disease and childhood leukaemia†

Ockleford¹,

Adriaanse²,

Berny³

et al. 2017

EFS2

View full text Add to dashboard Cite

In 2013, EFSA published a literature review on epidemiological studies linking exposure to pesticides and human health outcome. As a follow up, the EFSA Panel on Plant Protection Products and their residues (PPR Panel) was requested to investigate the plausible involvement of pesticide exposure as a risk factor for Parkinson's disease (PD) and childhood leukaemia (CHL). A systematic literature review on PD and CHL and mode of actions for pesticides was published by EFSA in 2016 and used as background documentation. The Panel used the Adverse Outcome Pathway (AOP) conceptual framework to define the biological plausibility in relation to epidemiological studies by means of identification of specific symptoms of the diseases as AO. The AOP combines multiple information and provides knowledge of biological pathways, highlights species differences and similarities, identifies research needs and supports regulatory decisions. In this context, the AOP approach could help in organising the available experimental knowledge to assess biological plausibility by describing the link between a molecular initiating event (MIE) and the AO through a series of biologically plausible and essential key events (KEs). As the AOP is chemically agnostic, tool chemical compounds were selected to empirically support the response and temporal concordance of the key event relationships (KERs). Three qualitative and one putative AOP were developed by the Panel using the results obtained. The Panel supports the use of the AOP framework to scientifically and transparently explore the biological plausibility of the association between pesticide exposure and human health outcomes, identify data gaps, define a tailored testing strategy and suggests an AOP's informed Integrated Approach for Testing and Assessment (IATA).

show abstract

“…MPTP-induced selective DA neuron toxicity is speciesspecific and therefore it is usually used to model PD mainly in primates and mice [26][27][28]. Age and gender may influence the susceptibility of the animals to MPTP [29].…”

Section: -Hydroxydopamine-lesioned Modelmentioning

confidence: 99%

“…Age and gender may influence the susceptibility of the animals to MPTP [29]. Although MPTP is more often used in mice models than in primates, largely because of lower cost, primate models are preferred when testing drug treatment protocols before human studies since they are more reproducible and better resemble human PD [27][28][29][30]. MPTP is mainly administered via systemic route through subcutaneous, intravenous, or intracarotid injections.…”

Section: -Hydroxydopamine-lesioned Modelmentioning

confidence: 99%

Animal Models of Parkinson's Disease: A Gateway to Therapeutics?

Sayana

Jankovic

2014

Neurotherapeutics

View full text Add to dashboard Cite

Parkinson's disease (PD) is a progressive, neurodegenerative disorder of unknown etiology, although a complex interaction between environmental and genetic factors has been implicated as a pathogenic mechanism of selected neuronal loss. A better understanding of the etiology, pathogenesis, and molecular mechanisms underlying the disease process may be gained from research on animal models. While cell and tissue models are helpful in unraveling involved molecular pathways, animal models are much better suited to study the pathogenesis and potential treatment strategies. The animal models most relevant to PD include those generated by neurotoxic chemicals that selectively disrupt the catecholaminergic system such as 6-hydroxydopamine; 1-methyl-1,2,3,6-tetrahydropiridine; agricultural pesticide toxins, such as rotenone and paraquat; the ubiquitin proteasome system inhibitors; inflammatory modulators; and several genetically manipulated models, such as α-synuclein, DJ-1, PINK1, Parkin, and leucine-rich repeat kinase 2 transgenic or knock-out animals. Genetic and nongenetic animal models have their own unique advantages and limitations, which must be considered when they are employed in the study of pathogenesis or treatment approaches. This review provides a summary and a critical review of our current knowledge about various in vivo models of PD used to test novel therapeutic strategies.

show abstract

Age-related effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment of common marmosets

Cited by 59 publications

References 31 publications

Diminished adult neurogenesis in the marmoset brain precedes old age

Diminished adult neurogenesis in the marmoset brain precedes old age

Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson's disease and childhood leukaemia†

Animal Models of Parkinson's Disease: A Gateway to Therapeutics?

Contact Info

Product

Resources

About