Age-related fatty infiltration of lumbar paraspinal muscles: a normative reference database study in 516 Chinese females

Peng, Xuebiao; Li, Xintong; Xu, Zhengyang; Cai, Wei; Yang, Shuai; Liao, Weihua; Cheng, Xiaoguang

doi:10.21037/qims-19-835

Cited by 37 publications

(29 citation statements)

References 41 publications

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“…An age-related increase of IMAT of the quadriceps muscle of elderly inpatients (> 65 years) was also reported using ultrasound [ 28 ]. In abdominal CT images of Chinese women, Peng et al [ 29 ] showed an age-related increase of IMAT and a decrease of muscle cross-sectional area of the paraspinal muscles. An age-related increase of paraspinal FF has also been detected by MRI [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

The effect of ageing on fat infiltration of thigh and paraspinal muscles in men

et al. 2022

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Background Myosteatosis, skeletal muscle fat infiltration, is associated with inflammation and fibrosis. The age-related increase of myosteatosis is an important characteristic of sarcopenia and contributes to fragility. Aims To investigate the impact of healthy aging on intermuscular adipose tissue (IMAT) and muscle fat fraction (FF) in the thigh and the paraspinal muscles in males. Methods In 54 healthy males (age 20–70), all active hobby golfers, magnetic resonance imaging was performed to determine volume of IMAT, volume of muscle tissue (MT) and of percentage of FF. Results Between ages 20–70, at the thigh, IMAT/MT volume and MT FF increased annually by 2.9% and 1.3%, respectively. At the psoas IMAT/Psoas volume did not change with age. MT FF increased by 1.5% annually. At the erector spinae IMAT/Erector volume decreased by 0.3% and MT FF increased by 2.8% annually. Discussion With increasing age, in males, thigh muscle atrophied, muscle tissue was partly replaced by adipose tissue and remaining muscle tissue also contained more fat. Similar effects were observed in the erector spinae. The psoas muscle did not atrophy, although MT FF also increased with age. Overall correlations with age were weak to moderate with higher correlations observed in the paraspinal muscles. Conclusions Age-related increases of muscle fat infiltration were observed in the thigh and in the spine. Muscle atrophy did not occur in the psoas. In cross-sectional studies, an adjustment of volumetric parameters by muscle volume is advisable when comparing age-dependent results.

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Section: Introductionmentioning

confidence: 99%

The effect of ageing on fat infiltration of thigh and paraspinal muscles in men

et al. 2022

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“…Although MRI is more commonly used, several previous studies have used CT for the evaluation of FI and reported the reliability of CT evaluation [6][7][8][9]. The CSA and FI of the lumbar muscles are associated with age, sex, body mass index (BMI), and LBP [10][11][12]. In a previous study, the FI could be measured as the ratio of FCSA to gross cross-sectional area (GCSA) [13].…”

Section: Introductionmentioning

confidence: 99%

The Quantity and Quality of Lumbar Muscles and Lumbopelvic Parameters in Patients With Degenerative Spondylolisthesis

Ohyama¹,

Aoki²,

Inoue³

et al. 2021

Cureus

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IntroductionLumbar degenerative spondylolisthesis (DS) is one of the most common causes of low back pain. The lumbar muscles, such as the psoas major (PM), erector spinae (ES), and multifidus (MF) muscles, play an important role in the stability and functional movement of the lumbar spine. The quantities and qualities of these muscles may be related to the occurrence of DS and lumbopelvic parameters, such as lumbar lordosis (LL) and sacral slope (SS). However, the influence of lumbar muscles on DS and lumbopelvic alignment is not well understood. MethodsPatients with L4 DS (DS group, n=25) and without DS (non-DS group, n=25) were included. Using sagittal reconstructed CT images of patients who visited our hospital for reasons other than low back disorders, LL, upper lumbar lordosis ([ULL] L1-L4), lower lumbar lordosis ([LLL] L4-S1), and SS were examined. To evaluate the quantity and quality of lumbar muscles, the gross cross-sectional area (GCSA), functional cross-sectional area (FCSA), and fat infiltration (FI) of the PM, ES, and MF muscles were measured by CT images. The lumbopelvic parameters, FCSA, GCSA, and FI of lumbar muscles were compared between the two groups. Then, each lumbar muscle parameter was analyzed for correlation with DS and lumbopelvic parameters. ResultsDS patients displayed significantly greater ULL and lower FI of the PM and ES muscles than non-DS patients (p=0.0078, 0.031, and 0.010, respectively). The FI of the ES muscle was significantly correlated with the presence of DS (p=0.010). The FCSA of the ES and MF muscles and the GCSA of the MF muscle showed a significant correlation with LL and SS in the non-DS group (p<0.05), but not in the DS group.. ConclusionULL was greater in L4 DS patients, possibly related to the better quality of the ES muscle. All DS patients showed mild (grade I) spondylolisthesis, suggesting the possibility that lumbar muscle quality is better in patients with mild DS than in those without DS. The ES and MF muscles may play an important role in maintaining the lumbar lordotic angle in non-DS patients but not in DS patients.

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“…On the contrary, the FI% of the paraspinal muscles gradually increased with aging. Peng et al used the qCT imaging to investigate 516 Chinese females, and they found that the fatty infiltration of the paraspinal muscles increased with aging [ 20 ]. The erector spinae are primarily more vertical in comparison to the multifidus, which means that they might bear more pressure.…”

Section: Discussionmentioning

confidence: 99%

Age- and sex-dependent differences in the morphology and composition of paraspinal muscles between subjects with and without lumbar degenerative diseases

Huang

Fang

Kong

et al. 2022

BMC Musculoskelet Disord

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Background The quality of the paraspinal muscles has been recommended as a surrogate marker for the evaluation of the severity of the lumbar degenerative diseases (LDD). The purpose of this study is to determine the age- and sex-dependent differences in the morphology and composition of the paraspinal muscles between LDD and asymptomatic subjects. Methods We analyzed data from 370 patients and 327 asymptomatic volunteers aged between 18–85 years. The measurement of the cross-sectional area (CSA) of the erector spinae, multifidus, and psoas at the L4/5-disc level was performed by the magnetic resonance imaging (MRI). The fatty infiltration ratio (FI %) of the multifidus and erector spinae was calculated. Results FI % of the lumbar paraspinal muscles were significantly and positively correlated with the severity of LDD instead of the CSA. Males had greater CSA than females, and females showed higher FI % than males in the paraspinal muscles. With the increase of age, the CSA of the lumbar paraspinal muscles gradually decreased, and the psoas showed the most significant decreasing trend. However, the FI % gradually increased in both LDD and asymptomatic groups with aging. Conclusion Age- and sex-dependent differences were found in the morphology and composition of the paraspinal muscles between subjects with and without LDD. Further long-term follow up investigations and basic studies will continue to confirm the natural history of the paraspinal muscles with aging and their association with LDD.

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Age-related fatty infiltration of lumbar paraspinal muscles: a normative reference database study in 516 Chinese females

Cited by 37 publications

References 41 publications

The effect of ageing on fat infiltration of thigh and paraspinal muscles in men

The effect of ageing on fat infiltration of thigh and paraspinal muscles in men

The Quantity and Quality of Lumbar Muscles and Lumbopelvic Parameters in Patients With Degenerative Spondylolisthesis

Age- and sex-dependent differences in the morphology and composition of paraspinal muscles between subjects with and without lumbar degenerative diseases

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