Age-related GABAA receptor changes in rat auditory cortex

Caspary, Donald M.; Hughes, Larry F.; Ling, Lynne

doi:10.1016/j.neurobiolaging.2012.11.009

Cited by 71 publications

(53 citation statements)

References 98 publications

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“…In addition, the decreased expression of GABA receptor subunits or GAD had been reported in the other cortex of rodent or primate in aged groups (Gutierrez et al, 1994(Gutierrez et al, , 1997Caspary et al, 1999;Ling et al, 2005;Rissman et al, 2006;Caspary et al, 2013). These data suggested a reduction in GABAergic inhibition in senescence ones, which might be one of the key mechanisms explaining the decline of visual function during senescence.…”

Section: Introductionmentioning

confidence: 53%

Age-related gene expression change of GABAergic system in visual cortex of rhesus macaque

Liao

Han

et al. 2016

Gene

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Section: Introductionmentioning

confidence: 53%

Age-related gene expression change of GABAergic system in visual cortex of rhesus macaque

Liao

Han

et al. 2016

Gene

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“…Declines in the function of inhibitory circuits in the auditory cortex, which is mostly mediated by GABAergic interneurons through feed-forward or feedback connections, have been documented in detail in aging animal models (4,23,24,(51)(52)(53). These major types of GABAergic interneurons expressing PV and SOM are argued to contribute to cortical signal representation, local and system coordination, and experience-dependent plasticity (14,18,22,(54)(55)(56)(57).…”

Section: Discussionmentioning

confidence: 99%

Positive impacts of early auditory training on cortical processing at an older age

Cheng

Jia

Zhang

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Progressive negative behavioral changes in normal aging are paralleled by a complex series of physical and functional declines expressed in the cerebral cortex. In studies conducted in the auditory domain, these degrading physical and functional cortical changes have been shown to be broadly reversed by intensive progressive training that improves the spectral and temporal resolution of acoustic inputs and suppresses behavioral distractors. Here we found older rats that were intensively trained on an attentionally demanding modulation-rate recognition task in young adulthood substantially retained training-driven improvements in temporal rate discrimination abilities over a subsequent 18-mo epoch-that is, forward into their older age. In parallel, this young-adult auditory training enduringly enhanced temporal and spectral information processing in their primary auditory cortices (A1). Substantially greater numbers of parvalbumin-and somatostatin-labeled inhibitory neurons (closer to the numbers recorded in young vigorous adults) were recorded in the A1 and hippocampus in old trained versus untrained age-matched rats. These results show that a simple form of training in young adulthood in this rat model enduringly delays the otherwise expected deterioration of the physical status and functional operations of the auditory nervous system, with evident training impacts generalized to the hippocampus.aging | auditory cortex | behavioral training | cortical processing | inhibition A degradation of the status of physical brain machinery, expressed by a decline in its temporal processing abilities, has been repeatedly associated with its deteriorating functional status in normal aging (1-4). Recent studies have shown that the machinery that supports processing accuracy and speed, as well as the processes supporting attention control and distractor suppression, can be substantially rejuvenated via simple forms of intensive training in the aged-rat model (4, 5). With auditory perceptual training, in parallel with recovery in behavioral abilities to that matching young-animal performance levels, serials of key physical, chemical, and functional aspects of cortical processing machinery in the trained rats were shown to be restored to a physical or functional status that approached that normally recorded in vigorous young-adult animals.In human studies, substantial changes in speed of processing (SOP) and in other spectro-temporal (or spatiotemporal) signal resolution of performance abilities have been shown to result from attention-demanding, speed-challenged auditory (3, 5-7) or visual training (8-11). For example, the accurate behavioral identification and stimulus-order reconstruction of rapidly successive auditory stimuli was restored in human individuals trained in their eighth decade of life to a performance level normally typifying human performance abilities recorded in their third or fourth decade (3, 6).Our goal here was to define the magnitude and endurance of an intense dose of attention-demanding modulation di...

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“…Previous animal studies have demonstrated changes in GABAergic neurotransmission in the inferior colliculus (Caspary et al, 1999; Caspary et al, 1990; Ouda and Syka, 2012), cochlear nuclei (Tang et al, 2014) and auditory cortex (Caspary et al, 2013; Ling et al, 2005; Ouda et al, 2008) of the Fischer 344 rat (a model of presbycusis), including decreased concentrations of GABA, decreased GABA release, decreased GABA B receptor binding and decreased numbers of presynaptic terminals. Therefore, reduced GABA+ concentrations in patients with presbycusis might reflect dysfunctional GABAergic neurotransmission in the central auditory system.…”

Section: Discussionmentioning

confidence: 99%

Decreased auditory GABA+ concentrations in presbycusis demonstrated by edited magnetic resonance spectroscopy

Gao

Wang

et al. 2015

NeuroImage

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Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the central auditory system. Altered GABAergic neurotransmission has been found in both the inferior colliculus and the auditory cortex in animal models of presbycusis. Edited magnetic resonance spectroscopy (MRS), using the MEGA-PRESS sequence, is the most widely used technique for detecting GABA in the human brain. However, to date there has been a paucity of studies exploring changes to the GABA concentrations in the auditory region of patients with presbycusis. In this study, sixteen patients with presbycusis (5 males/11 females, mean age 63.1 ± 2.6 years) and twenty healthy controls (6 males/14 females, mean age 62.5 ± 2.3 years) underwent audiological and MRS examinations. Pure tone audiometry from 0.125 to 8 KHz and tympanometry were used to assess the hearing abilities of all subjects. The pure tone average (PTA; the average of hearing thresholds at 0.5, 1, 2, and 4 kHz) was calculated. The MEGA-PRESS sequence was used to measure GABA+ concentrations in 4 × 3 × 3 cm3 volumes centered on the left and right Heschl’s gyri. GABA+ concentrations were significantly lower in the presbycusis group compared to the control group (left auditory regions: p = 0.002, right auditory regions: p = 0.008). Significant negative correlations were observed between PTA and GABA+ concentrations in the presbycusis group (r = −0.57, p = 0.02), while a similar trend was found in the control group (r = −0.40, p = 0.08). These results are consistent with a hypothesis of dysfunctional GABAergic neurotransmission in the central auditory system in presbycusis, and suggest a potential treatment target for presbycusis.

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Age-related GABAA receptor changes in rat auditory cortex

Cited by 71 publications

References 98 publications

Age-related gene expression change of GABAergic system in visual cortex of rhesus macaque

Age-related gene expression change of GABAergic system in visual cortex of rhesus macaque

Positive impacts of early auditory training on cortical processing at an older age

Decreased auditory GABA+ concentrations in presbycusis demonstrated by edited magnetic resonance spectroscopy

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