Age-related hair changes in men: Mechanisms and management of alopecia and graying

Mirmirani, Paradi

doi:10.1016/j.maturitas.2014.10.008

Cited by 39 publications

(40 citation statements)

References 52 publications

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“…There are many causes of hair miniaturisation and baldness, including the use of colouring agents, substantial contact with heat sources and chemicals, significant exposure to ultraviolet light, regular smoking and hormone-related mechanisms (Mirmirani, 2015). The most studied factor is androgen-related hair loss, often known as androgenic alopecia (AGA).…”

Section: Introductionmentioning

confidence: 99%

“…In patients with AGA, testosterone is extensively transformed into dihydrotestosterone by the enzyme 5α-reductase, which has a much higher binding affinity than testosterone in androgen receptors (Hoffmann, 2002). This stronger binding affects the androgen pathway and triggers gradual hair miniaturisation and baldness (Mirmirani, 2015). Therefore, the inhibition of 5α-reductase, which reduces the decline in testosterone, is currently a treatment target for AGA.…”

Section: Introductionmentioning

confidence: 99%

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In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss

Fong

Tong

et al. 2015

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss

Fong

Tong

et al. 2015

Journal of Ethnopharmacology

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“…41) The reaction were initiated with S. muticum extract (0.1, 1, 10, 100 µg/mL), the solvent fraction of S. muticum extract (0.1, 1, 10 µg/mL) or apo-9′-fucoxanthinone (0.01, 0.1, 1, 10 µM) containing reaction buffer [40 mM potassium phosphate buffer (pH 6.6), 1 mM DTT, 2 mM reduced nicotinamide adenine dinucleotide phosphate, and 120 nCi [1,2,6, H] testosterone]. An independent set of the reaction (n=3) was examined and finasteride (2 nM) was used as a positive control.…”

Section: Reagentsmentioning

confidence: 99%

“…Hair loss (known as alopecia) is currently highlighted as an increasing disorder in both men and women 1,2) with complex causes that cannot be solved easily. The imbalances of hormones such as thyroid, estrogen and androgen, as well as autoimmune diseases, stress, shock, poor nutrition and so on have been known to induce alopecia.…”

mentioning

confidence: 99%

Promotion Effect of Apo-9′-fucoxanthinone from <i>Sargassum muticum</i> on Hair Growth <i>via</i> the Activation of Wnt/β-Catenin and VEGF-R2

Kang

Yoo

Hyun

et al. 2016

Biological & Pharmaceutical Bulletin

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This study was conducted to evaluate the effects of Sargassum muticum extract and apo-9′-fucoxanthinone, a principal component of S. muticum, on hair growth. When rat vibrissa follicles were treated with S. muticum extract for 21 d, the hair-fiber lengths for the vibrissa follicles increased significantly. Treatment with the S. muticum extract and the EtOAc fraction of the S. muticum extract markedly increased the proliferation of dermal papilla cells (DPCs) and decreased the 5α-reductase activity. In addition, the EtOAc fraction of the S. muticum extract significantly promoted anagen initiation in C57BL/6 mice. Especially, apo-9′-fucoxanthinone, an active constituent from the S. muticum extract, caused an increase in DPC proliferation and a decrease in 5α-reductase activity. To elucidate the molecular mechanisms of apo-9′-fucoxanthinone on the proliferation of DPCs, we examined the level of various signaling proteins. Apo-9′-fucoxanthinone increased the level of vascular endothelial growth factor receptor-2 (VEGF-R2), Wnt/β-catenin signaling proteins such as phospho(ser9)-glycogen synthase kinase-3β (GSK-3β) and phospho(ser552)-β-catenin, whereas apo-9′-fucoxanthinone did not affect the transforming growth factor-β (TGF-β) signaling proteins such as Smad2/3. These results suggest that apo-9′-fucoxanthinone from S. muticum could have the potential for hair growth with DPC proliferation via the activation of Wnt/β-catenin signaling and the VEGF-R2 pathway.

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“…Hair growth increases during puberty under hormonal influence, and eventually decreases because of complex systemic signals (67). Also, age is independently associated with macrovascular events (68).…”

Section: Evaluation Of the Hypothesismentioning

confidence: 99%

Hair follicle characteristics as early marker of Type 2 Diabetes

et al. 2016

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Type 2 Diabetes mellitus (DM2) includes a continuum of metabolic disorders characterized by hyperglycemia that causes several chronic long-term complications such as coronary artery disease, peripheral arterial disease, nephropathy, and neuropathy. The hair follicle could reveal signs of early vascular impairment, yet its relationship to early metabolic injuries has been largely ignored. We propose that in earlier stages of the continuum of DM2-related metabolic disorders, a group of susceptible patients who do not yet meet the diagnostic criteria to be considered as persons with DM2 may present chronic vascular impairment and end organ damage, including hair follicle damage, which can be evaluated to identify an early risk marker. This hypothesis is based in the association found between insulin resistance and alopecia in non-diabetic persons, and the hair loss on the lower limbs as a manifestation of long-term peripheral arterial disease among subjects with DM2. In order to test this hypothesis, studies are required to evaluate if hair follicle characteristics are related to and can predict hyperglycemic complications, and if they do so, which feature of the hair follicle, such as hair growth, best characterizes such DM2-related conditions. If this hypothesis were proven to be true, significant advances towards a personalized approach for early prevention strategies and management of DM2 would be made. By focusing on the hair follicles, early stages of metabolic-related organ damage could be identified using non-invasive low-cost techniques. In so doing, this approach could provide early identification of DM2-susceptible individuals and lead to the early initiation of adequate primary prevention strategies to reduce or avoid the onset of large internal organ damage.

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Age-related hair changes in men: Mechanisms and management of alopecia and graying

Cited by 39 publications

References 52 publications

In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss

In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss

Promotion Effect of Apo-9′-fucoxanthinone from <i>Sargassum muticum</i> on Hair Growth <i>via</i> the Activation of Wnt/β-Catenin and VEGF-R2

Hair follicle characteristics as early marker of Type 2 Diabetes

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