Age-related hearing impairment (ARHI): environmental risk factors and genetic prospects

Fransén, Erik; Lemkens, Nele; Laer, Lut Van; Camp, Guy Van

doi:10.1016/s0531-5565(03)00032-9

Cited by 84 publications

(60 citation statements)

References 36 publications

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“…Similar findings were found in other studies 7,8 . Although there is a constant decline in hearing acuity with aging, age of onset, progression and severity of ARHI show great variation 2 . This connotes that with the increasing population of the elderly in the population, the burden of presbycusis will possibly increase.…”

Section: Discussionmentioning

confidence: 99%

“…Consequently most patients develop relative alienation from the environment and may be prone to emotional disturbances. Presbycusis is the most common sensory impairment associated with ageing and has prevalence of about 35% between ages 60 and 70 years 2 . The global increase in the average life expectancy including those of the developing countries suggests that the population of the elderly is on the increase with a projected increase in the incidence and prevalence of presbycusis.…”

Section: Introductionmentioning

confidence: 99%

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Clinical and audiometric features of presbycusis in Nigerians

Sogebi¹,

Olusoga-Peters²,

Oluwapelumi³

2014

Afr H. Sci.

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Background: Presbycusis is the most common sensory impairment associated with ageing and it presents with variability of symptoms. Physicians need to recognize early clinical and audiometric signs of presbycusis in order to render adequate and quality care to patients and reduce associated morbidities. Objective: To characterize the clinical modes of presentation and the typical audiometric tracings among patients with presbycusis. Methods: This descriptive, prospective hospital-based study was conducted in the Ear, Nose and Throat (ENT) clinic of Olabisi Onabanjo University Teaching Hospital, (OOUTH) Sagamu, Nigeria. Patients with clinical diagnosis of presbycusis confirmed with bilateral sensorineural hearing loss (SNHL) on diagnostic audiometry were administered with questionnaires. Information obtained was analyzed using SPSS statistical package version 17.0 and presented in descriptive forms as percentages, means and graphs. Results: Sixty-nine patients were diagnosed with presbycusis (M:F =1.6:1). Modal age group was 71-80 years. Hearing loss 88.4%, tinnitus 79.7% and vertigo 33.3% were the major symptoms on presentation. The average duration of symptoms before presentation was 2.6 years. There was positive history of ototoxic drugs usage in 24.6 %, family history in 11.6 %, hypertension in 34.8% and osteoarthritis in 13.0%. The most common type of audiometric pattern was strial. Hearing losses increased with age both at the speech and at the higher frequencies of sounds. Conclusions: We found hearing impairment affected both speech and higher frequencies and the strial type of audiometric pattern was most common. The need for screening for hearing impairment from early middle age in symptomatic individuals is emphasized.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical and audiometric features of presbycusis in Nigerians

Sogebi¹,

Olusoga-Peters²,

Oluwapelumi³

2014

Afr H. Sci.

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“…A study with non-diabetic patients reported a significant association between a high body mass index (BMI) and hearing loss (26) . Contrary to the results presented here, another survey conducted with middle-aged diabetic men shows that there is no association between overweight or obesity and hearing loss (27) .…”

Section: Discussionmentioning

confidence: 99%

Alterações auditivas associadas a complicações e comorbidades no diabetes mellitus tipo 2

Ferreira¹,

Câmara

Almeida

et al. 2013

Audiol., Commun. Res.

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OBJETIVO: Investigar a presença de alterações auditivas, representadas por diminuição do limiar audiométrico e/ou ausência de emissões otoacústicas, associadas às características gerais, complicações crônicas e comorbidades em pacientes com diabetes tipo 2. MÉTODOS: Estudo realizado em unidade de atenção secundária, em Fortaleza, de abril a julho de 2010. Amostra de 152 pacientes de 36 a 60 anos de idade, portadores de diabetes tipo 2. Analisou-se dados clínicos relacionados ao diabetes e à avaliação audiológica, composta por audiometria tonal liminar, emissões otoacústicas evocadas por estímulo transiente e emissões otoacústicas evocadas produto de distorção. RESULTADOS: O gênero feminino predominou, com 95 (62,5%) pacientes. A média de idade foi 53,4 anos. Verificou-se perda auditiva sensorioneural em 96 (63,2%) pacientes, sendo a maioria perda coclear (83,3%). Cento e catorze pacientes (75%) apresentaram ausência de emissões transientes e 120 (78,9%), ausência de emissões produto de distorção. Os homens diabéticos demonstraram 4,4 vezes mais chance de perda auditiva que as mulheres. Quanto maior o tempo da doença, maior a probabilidade de perda auditiva. Os pacientes diabéticos acima de 50 anos também apresentaram maior chance para perda auditiva. CONCLUSÃO: Das comorbidades e complicações associadas ao diabetes, o sobrepeso/obesidade constitui fator de risco para alteração auditiva, estando associado à perda auditiva e ausência de emissões transientes. Os pacientes diabéticos com sobrepeso/obesidade apresentaram três vezes mais chances de alterações na audiometria e emissões otoacústicas.

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“…1 A number of studies have shown that high-frequency hearing loss can also occur in early age (<45 years) and in the absence of environmental risk factors: 3 these observations could provide initial evidence of a genetic background of presbycusis.…”

Section: Genetics Of Presbycusismentioning

confidence: 99%

“…2,3 In particular, according to UK studies, in the group aged 61-70 years, the prevalence of hearing loss (25 dB or more) is about 37%, and this increases to 60% in the group aged 71-80 years. 1 Males demonstrate a higher incidence of presbycusis with a rapid deterioration in hearing threshold (Baltimore Longitudinal Study of Aging).…”

Section: Epidemiologymentioning

confidence: 99%

Genetics of presbycusis and presbystasis

Ciorba

Hatzopoulos

Bianchini

et al. 2015

Int J Immunopathol Pharmacol

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Presbycusis and presbystasis represent relevant problems of aging, caused by the increase in life expectancy in developed countries. As such, it is advantageous to better understand the physiopathological mechanisms of these age-related inner ear diseases. The hypothesis that presbycusis and presbystasis have a genetic background was proposed some years ago. Several studies (in humans and animals) are available in the literature, and possible genes involved in the physiopathology of both diseases have been identified. The aim of this paper is to present an overview of the information available in the current medical literature on presbycusis and presbystasis.

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Age-related hearing impairment (ARHI): environmental risk factors and genetic prospects

Cited by 84 publications

References 36 publications

Clinical and audiometric features of presbycusis in Nigerians

Clinical and audiometric features of presbycusis in Nigerians

Alterações auditivas associadas a complicações e comorbidades no diabetes mellitus tipo 2

Genetics of presbycusis and presbystasis

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