Age-Related Hearing Loss, Methylmalonic Acid, and Vitamin B
            <sub>12</sub>
            Status in Older Adults

Park, Sohyun; Johnson, Mary Ann; Shea-Miller, Kelly J.; Chicchis, Albert R. De; Allen, Robert H.; Stabler, Sally P.

doi:10.1300/j052v25n03_08

Cited by 17 publications

(20 citation statements)

References 32 publications

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“…Moreover, vitamin B 12 deficiency was associated with poor cognition in this study (77) and confirmed in a subsequent study (79). Vitamin B 12 deficiency was associated with several metabolic abnormalities (80) and with hearing loss (81), suggesting that vitamin B 12 deficiency may be a modifiable risk factor for hearing loss.…”

Section: Webinar On Food Insecurity In Older Georgianssupporting

confidence: 79%

Food Insecurity, Food and Nutrition Programs, and Aging: Experiences from Georgia

Lee

Fischer

Johnson

2010

Journal of Nutrition For the Elderly

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Food insecurity and hunger are real and growing problems in the United States. Among older adults, the prevalence of food insecurity is at a 14-year high and occurred in more than 8% of households with older adults in 2008 according to USDA. However, the rate is at least 10% higher when less severe degrees of food insecurity are considered. Emerging research suggests that several segments of the older adult population are particularly vulnerable to food insecurity, including those receiving or requesting congregate meals, home-delivered meals, and other community-based services. Thus, national and state estimates of food insecurity may obscure problems in specific subgroups of older adults. Older adults are at high risk of chronic health problems that can be exacerbated by food insecurity, poor nutritional status, and low physical activity. To help improve targeting of food and nutrition programs to those most in need because of food insecurity and/or nutrition-related chronic health problems, the purposes of this review are (1) to define the prevalence and consequences of food insecurity; (2) to discuss the outcomes of some food, nutrition, disease prevention, and health promotion programs targeted to older adults in Georgia, the state with the 3rd highest prevalence of food insecurity; and (3) to make recommendations for research, service, and advocacy related to monitoring and alleviating food insecurity and related health problems in older adults.

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Section: Webinar On Food Insecurity In Older Georgianssupporting

confidence: 79%

Food Insecurity, Food and Nutrition Programs, and Aging: Experiences from Georgia

Lee

Fischer

Johnson

2010

Journal of Nutrition For the Elderly

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“…Profile 2 may include individuals with an often genetic TC I deficiency, the frequency of which may be higher than that of pernicious anemia, and in whom serum vitamin B-12 is low but MMA and tHcy are not abnormal (39) or individuals who lack the common fucosyltransferase polymorphism associated with higher vitamin B-12 concentrations (43). Given the high proportion of younger women in profile 2, many of the low vitamin B-12 concentrations may have been affected by hormonal factors unrelated to functional vitamin B-12 status.…”

Section: Discussionmentioning

confidence: 99%

“…For this analysis, we added an additional cutoff of .296 pmol/L (.400 pg/mL) to the original Stabler et al criteria (30). We classified elevated MMA using 2 concentrations: .376 nmol/L (31)(32)(33)(34)(35) and .271 nmol/L (24,28,32,(36)(37)(38)(39). We also examined 4 categories of MMA based on the above cutoffs (.376 and .271 nmol/L) and .210 nmol/L (14,23,40,41).…”

Section: Biochemical Methodsmentioning

confidence: 99%

Monitoring of vitamin B-12 nutritional status in the United States by using plasma methylmalonic acid and serum vitamin B-12

Bailey¹,

Carmel²,

Green³

et al. 2011

The American Journal of Clinical Nutrition

136

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Background: Various definitions, criteria, tests, and cutoffs have been used to define vitamin B-12 status; however, a need exists for the systematic study of vitamin B-12 status in the United States because of concerns about high folic acid intakes and the potential for associated adverse effects. Objective: The objective was to determine the effect of different cutoff choices on outcomes and of the different degrees of serum vitamin B-12 status, definable by the concurrent use of a functional and circulating marker as the first steps to developing a data-based consensus on the biochemical diagnosis of vitamin B-12 deficiency. Design: Data from NHANES, a nationally representative crosssectional survey, were examined for adults aged .19 y (mean 6 SD age: 45 6 1 y) from 1999 to 2004 (n = 12,612). Results: Commonly used cutoffs had a greater effect on prevalence estimates of low vitamin B-12 status with the use of vitamin B-12 than with the use of methylmalonic acid (MMA; 3-26% and 2-6%, respectively). A cutoff of .148 pmol/L for vitamin B-12 and of 210 nmol/L for MMA resulted in significant misclassifications. Approximately 1% of adults had a clear vitamin B-12 deficiency (low vitamin B-12 and elevated MMA); 92% of adults had adequate vitamin B-12 status. A high percentage of younger women characterized the group with low vitamin B-12 and normal MMA (2% of adults) and may have falsely reflected low vitamin B-12. Adults with elevated MMA (5%) only were demographically similar (ie, by age and race) to the deficient group and may have included some individuals with early vitamin B-12 deficiency. Conclusions: These analyses indicate the challenges of assessing vitamin B-12 status when uncertainties exist about the appropriate cutoffs. Future studies should determine definable endpoints to achieve this goal.Am J Clin Nutr 2011;94:552-61.

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“…In contrast, Berner et al ( 2000 ) failed to demonstrate any association between hearing level and vitamin B 12 or folic acid in 91 elderly subjects. A poor vitamin B 12 status was also evident in 93 older adults with hearing loss (Park et al, 2006 ) but short-term dietary supplementation with vitamin B 12 did not affect their hearing.…”

Section: Protection From Cochlear Pathology and Pathophysiologymentioning

confidence: 99%

Age-related hearing impairment and the triad of acquired hearing loss

Yang

Schrepfer

Schacht

2015

Front. Cell. Neurosci.

116

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Understanding underlying pathological mechanisms is prerequisite for a sensible design of protective therapies against hearing loss. The triad of age-related, noise-generated, and drug-induced hearing loss displays intriguing similarities in some cellular responses of cochlear sensory cells such as a potential involvement of reactive oxygen species (ROS) and apoptotic and necrotic cell death. On the other hand, detailed studies have revealed that molecular pathways are considerably complex and, importantly, it has become clear that pharmacological protection successful against one form of hearing loss will not necessarily protect against another. This review will summarize pathological and pathophysiological features of age-related hearing impairment (ARHI) in human and animal models and address selected aspects of the commonality (or lack thereof) of cellular responses in ARHI to drugs and noise.

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Age-Related Hearing Loss, Methylmalonic Acid, and Vitamin B ₁₂ Status in Older Adults

Cited by 17 publications

References 32 publications

Food Insecurity, Food and Nutrition Programs, and Aging: Experiences from Georgia

Food Insecurity, Food and Nutrition Programs, and Aging: Experiences from Georgia

Monitoring of vitamin B-12 nutritional status in the United States by using plasma methylmalonic acid and serum vitamin B-12

Age-related hearing impairment and the triad of acquired hearing loss

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Age-Related Hearing Loss, Methylmalonic Acid, and Vitamin B 12 Status in Older Adults

Cited by 17 publications

References 32 publications

Food Insecurity, Food and Nutrition Programs, and Aging: Experiences from Georgia

Food Insecurity, Food and Nutrition Programs, and Aging: Experiences from Georgia

Monitoring of vitamin B-12 nutritional status in the United States by using plasma methylmalonic acid and serum vitamin B-12

Age-related hearing impairment and the triad of acquired hearing loss

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Age-Related Hearing Loss, Methylmalonic Acid, and Vitamin B ₁₂ Status in Older Adults