Age‐related hearing loss, vitamin B12, and folate in the elderly

Lasisi, Akeem O.; Fehintola, F. A.; Yusuf, Oyindamola B.

doi:10.1016/j.otohns.2010.08.031

Cited by 37 publications

(39 citation statements)

References 23 publications

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“…Reduced folic acid (FA) concentrations have been found in age-related HL (ARHL) and sudden SNHL, this decrease correlating with either reduced vitamin B 12 (Houston et al, 1999; Lasisi et al, 2010; Karli et al, 2013) or increased tHcy levels (Cadoni et al, 2004). Although Hcy concentrations reflect alterations in its metabolism (Figure 1), which include the methionine and folate cycles, as well as the transsulfuration pathway, no consistent association between mutations in genes of these pathways and SNHL has been reported (Durga et al, 2006; Uchida et al, 2011).…”

Section: Hyperhomocysteinemia and Neurosensorial Hearing Lossmentioning

confidence: 99%

“…To date, supplementation and nutrient deficiency studies have been conducted using laboratory animals, in which auditory thresholds, internal ear microvasculature, or inflammation have been evaluated (Schuknecht et al, 1974; Makishima, 1978); but only a few have analyzed Hcy metabolism following the lead of the epidemiological data (Houston et al, 1999; Cadoni et al, 2004; Lasisi et al, 2010). Two studies in mouse models have shown the relationship between Hcy metabolism and SNHL and the impact of folate deficiency (FD; Martínez-Vega et al, 2015a, 2016).…”

Section: Nutritional Interventions and Hearing Lossmentioning

confidence: 99%

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Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss

Partearroyo

Vallecillo

Pajares

et al. 2017

Front. Mol. Neurosci.

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Hearing loss (HL) is one of the most common causes of disability, affecting 360 million people according to the World Health Organization (WHO). HL is most frequently of sensorineural origin, being caused by the irreversible loss of hair cells and/or spiral ganglion neurons. The etiology of sensorineural HL (SNHL) is multifactorial, with genetic and environmental factors such as noise, ototoxic substances and aging playing a role. The nutritional status is central in aging disability, but the interplay between nutrition and SNHL has only recently gained attention. Dietary supplementation could therefore constitute the first step for the prevention and potential repair of hearing damage before it reaches irreversibility. In this context, different epidemiological studies have shown correlations among the nutritional condition, increased total plasma homocysteine (tHcy) and SNHL. Several human genetic rare diseases are also associated with homocysteine (Hcy) metabolism and SNHL confirming this potential link. Accordingly, rodent experimental models have provided the molecular basis to understand the observed effects. Thus, increased tHcy levels and vitamin deficiencies, such as folic acid (FA), have been linked with SNHL, whereas long-term dietary supplementation with omega-3 fatty acids improved Hcy metabolism, cell survival and hearing acuity. Furthermore, pharmacological supplementations with the anti-oxidant fumaric acid that targets Hcy metabolism also improved SNHL. Overall these results strongly suggest that cochlear Hcy metabolism is a key player in the onset and progression of SNHL, opening the way for the design of prospective nutritional therapies.

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Section: Hyperhomocysteinemia and Neurosensorial Hearing Lossmentioning

confidence: 99%

Section: Nutritional Interventions and Hearing Lossmentioning

confidence: 99%

Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss

Partearroyo

Vallecillo

Pajares

et al. 2017

Front. Mol. Neurosci.

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“…The relationship between nutritional deficiencies in vitamins, including folate deficiency, and hearing loss has been explored in a variety of epidemiological studies (Houston et al, 1999; Cadoni et al, 2004; Lasisi et al, 2010; Attias et al, 2012; Karli et al, 2013). However, the data obtained have not always been consistent.…”

Section: Discussionmentioning

confidence: 99%

“…Factors such as noise and ototoxic drugs are well-known effectors of this impairment, but more recently several epidemiological studies have shown the association between the nutritional status and hearing loss. Precisely, inadequate levels of folic acid have been correlated with hearing loss in the presence of reduced vitamin B 12 concentrations or hyperhomocysteinemia (Houston et al, 1999; Cadoni et al, 2004; Lasisi et al, 2010). Additional reports have explored the putative association of mutations in genes of the folate cycle and the impact of hearing loss, their results being somewhat inconsistent (Durga et al, 2006; Uchida et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Long-Term Dietary Folate Deficiency Accelerates Progressive Hearing Loss on CBA/Ca Mice

Martínez-Vega

Murillo-Cuesta

Partearroyo

et al. 2016

Front. Aging Neurosci.

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Dietary folic acid deficiency induced early hearing loss in C57BL/6J mice after 2-months, corroborates the epidemiological association previously described between vitamin deficiency and this sensory impairment. However, this strain is prone to early hearing loss, and hence we decided to analyze whether the effects exerted by folate deprivation follow the same pattern in a mouse strain such as CBA/Ca, which is resistant to hearing impairment. Here, we show results of a long-term study on hearing carried out on CBA/Ca mice subjected to dietary folate deprivation. Systemic changes included decreased serum folate levels, hyperhomocysteinemia and signs of anemia in the group fed with folate-deficient (FD) diet. Initial signs of hearing loss were detected in this strain after 8-months of vitamin deficiency, and correlated with histological damage in the cochleae. In conclusion, the data presented reinforce the importance of adequate folic acid levels for the auditory system and suggest that the impact of dietary deficiencies may depend on the genetic background.

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“…In fact, targeting mitochondria is becoming increasingly popular [82], and there were some successful attempts in treatment of hearing conditions using mitochondrial supplements [83][84][85][86][87][88][89].…”

Section: Mitochondrial Toxicity: Common Denominator Of Ototoxic Drugsmentioning

confidence: 99%

Ototoxicity: Old and New Foes

Szczepek¹

2017

Advances in Clinical Audiology

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Drug-induced ototoxicity has been known for centuries. Already in the seventeenth century, hearing loss was described to be a side effect of quinine. The post-World War II pharmaceutical industry boomed with the production of aminoglycoside antibiotics followed by diuretics and cytostatic drugs. Wide-spread and long-term usage of these medications brought the knowledge about their unwanted ototoxic effects. In the last decades, several new drugs appeared on the shelves of pharmacies and the hearing loss or tinnitus have been among the side effects of many of them. However, the awareness of community about new ototoxic medications is still not sufficient. New ototoxic drugs may belong to the class of phosphodiesterase-5 (PDE5) inhibitors, used to improve microcirculation and to treat erectile dysfunction. Moreover, interferons used for the therapy of hepatitis B and C, common painkiller paracetamol and hydrocodone, synthetic opioid methadone and the inhibitors of reverse transcriptase were demonstrated to induce adverse effects on hearing. Lastly, hearing loss linked to immunosuppressive drugs was documented in patients undergoing organ transplantation. Making the patients aware of adverse drug reactions and offering them audiological monitoring and intervention should be considered by respective therapists.

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Age‐related hearing loss, vitamin B12, and folate in the elderly

Abstract: Serum folate was significantly lower among elderly with ARHL. Trials on nutritional supplementation may substantiate the role of serum folate in ARHL.

Cited by 37 publications

References 23 publications

Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss

Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss

Long-Term Dietary Folate Deficiency Accelerates Progressive Hearing Loss on CBA/Ca Mice

Ototoxicity: Old and New Foes

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