2023
DOI: 10.14336/ad.2022.1109
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Age-Related Hormones Changes and Its Impact on Health Status and Lifespan

Abstract: The increase in life expectancy is accompanied with an increased consultation of age-related pathologies including endocrine disorders. Two main areas are focusing the attention of medical and social research in older population: the diagnosis and care of this heterogeneous population, and the interventional measures potentially useful to mitigate age-related functional declines and to increase health and quality of lifespan. Thus, better understanding the physiopathology of aging and establishing accurate dia… Show more

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Cited by 5 publications
(2 citation statements)
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“…Younger patients (<25 years) exhibited higher rates of menstrual regularity and symptom resolution with hormonal therapy, while older individuals (≥25 years) showed more favorable outcomes with surgical interventions and lifestyle modifications. This observation may be attributed to the potential for age-related changes in hormonal dynamics and the increased prevalence of anatomical abnormalities in older individuals, necessitating tailored treatment approaches [ 68 ].…”
Section: Discussionmentioning
confidence: 99%
“…Younger patients (<25 years) exhibited higher rates of menstrual regularity and symptom resolution with hormonal therapy, while older individuals (≥25 years) showed more favorable outcomes with surgical interventions and lifestyle modifications. This observation may be attributed to the potential for age-related changes in hormonal dynamics and the increased prevalence of anatomical abnormalities in older individuals, necessitating tailored treatment approaches [ 68 ].…”
Section: Discussionmentioning
confidence: 99%
“…The level of GHRH in the median eminence decreases in aged rats, while the SS level in the median eminence, as well as GHRH and SS level in the neuronal somata remains intact [48]. It was proposed that SS-induced inhibition of GH was sensitized in aged rats, indicating a possible cause for the age-related decrease in GH level in plasma [49]. However, the percentage of SS-immunoreactive neurons in the mediobasal hypothalamus, as well as their number, does not change in males and females with aging [22].…”
Section: Insulin/igf-1/gh Signalingmentioning
confidence: 99%