Age-related immune alterations and cerebrovascular inflammation

Finger, Carson; Moreno-González, Inés; Gutiérrez, Antonia; Moruno-Manchon, Jose F.; McCullough, Louise D.

doi:10.1038/s41380-021-01361-1

Cited by 91 publications

(60 citation statements)

References 247 publications

(239 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the BBB could also limit the transport of gut-derived molecules into the brain (48). Vulnerable BBB is caused by aging and may induce cerebrovascular inflammation and CNS disorder (49)(50)(51)(52).…”

Section: Blood-brain Barrier and Gut-derived Moleculesmentioning

confidence: 99%

Implications of Gut Microbiota in Neurodegenerative Diseases

et al. 2022

View full text Add to dashboard Cite

The morbidity associated with neurodegenerative diseases (NDs) is increasing, posing a threat to the mental and physical quality of life of humans. The crucial effect of microbiota on brain physiological processes is mediated through a bidirectional interaction, termed as the gut–brain axis (GBA), which is being investigated in studies. Many clinical and laboratory trials have indicated the importance of microbiota in the development of NDs via various microbial molecules that transmit from the gut to the brain across the GBA or nervous system. In this review, we summarize the implications of gut microbiota in ND, which will be beneficial for understanding the etiology and progression of NDs that may in turn help in developing ND interventions and clinical treatments for these diseases.

show abstract

Section: Blood-brain Barrier and Gut-derived Moleculesmentioning

confidence: 99%

Implications of Gut Microbiota in Neurodegenerative Diseases

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Significant structural and functional changes of brain capillaries have been reported with aging and in disease states [ 2 , 228 – 230 ]. For example, the brain of elderly humans [ 231 ] and of aged mice [ 22 ] displays capillary wall thinning and declines in capillary density, blood flow, vascular perfusion, angiogenic potentials, and barrier properties [ 16 – 18 ].…”

Section: Pathological and Age-induced Changes In Brain Endothelial Pr...mentioning

confidence: 99%

Historical and current perspectives on blood endothelial cell heterogeneity in the brain

Matsuoka

Buck

Vajrala

et al. 2022

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

Dynamic brain activity requires timely communications between the brain parenchyma and circulating blood. Brain–blood communication is facilitated by intricate networks of brain vasculature, which display striking heterogeneity in structure and function. This vascular cell heterogeneity in the brain is fundamental to mediating diverse brain functions and has long been recognized. However, the molecular basis of this biological phenomenon has only recently begun to be elucidated. Over the past century, various animal species and in vitro systems have contributed to the accumulation of our fundamental and phylogenetic knowledge about brain vasculature, collectively advancing this research field. Historically, dye tracer and microscopic observations have provided valuable insights into the anatomical and functional properties of vasculature across the brain, and these techniques remain an important approach. Additionally, recent advances in molecular genetics and omics technologies have revealed significant molecular heterogeneity within brain endothelial and perivascular cell types. The combination of these conventional and modern approaches has enabled us to identify phenotypic differences between healthy and abnormal conditions at the single-cell level. Accordingly, our understanding of brain vascular cell states during physiological, pathological, and aging processes has rapidly expanded. In this review, we summarize major historical advances and current knowledge on blood endothelial cell heterogeneity in the brain, and discuss important unsolved questions in the field.

show abstract

“…Immunosenescence is an age-dependent development of immune dysfunction that involves lymphoid organ remodelling, leading to reduced capacity to control inflammatory cytokines during and after the immune response. Immunosenescence can lead to chronic inflammation in ageing tissues, frequent infections, autoimmune diseases, and cancer due to impaired immune surveillance [21,[60][61][62][63][64].…”

Section: Immunosenescence and Inflammagingmentioning

confidence: 99%

Age-Related Hearing Loss: The Link between Inflammaging, Immunosenescence, and Gut Dysbiosis

Kociszewska

Vlajkovic²

2022

IJMS

View full text Add to dashboard Cite

This article provides a theoretical overview of the association between age-related hearing loss (ARHL), immune system ageing (immunosenescence), and chronic inflammation. ARHL, or presbyacusis, is the most common sensory disability that significantly reduces the quality of life and has a high economic impact. This disorder is linked to genetic risk factors but is also influenced by a lifelong cumulative effect of environmental stressors, such as noise, otological diseases, or ototoxic drugs. Age-related hearing loss and other age-related disorders share common mechanisms which often converge on low-grade chronic inflammation known as “inflammaging”. Various stimuli can sustain inflammaging, including pathogens, cell debris, nutrients, and gut microbiota. As a result of ageing, the immune system can become defective, leading to the accumulation of unresolved inflammatory processes in the body. Gut microbiota plays a central role in inflammaging because it can release inflammatory mediators and crosstalk with other organ systems. A proinflammatory gut environment associated with ageing could result in a leaky gut and the translocation of bacterial metabolites and inflammatory mediators to distant organs via the systemic circulation. Here, we postulate that inflammaging, as a result of immunosenescence and gut dysbiosis, accelerates age-related cochlear degeneration, contributing to the development of ARHL. Age-dependent gut dysbiosis was included as a hypothetical link that should receive more attention in future studies.

show abstract

Age-related immune alterations and cerebrovascular inflammation

Cited by 91 publications

References 247 publications

Implications of Gut Microbiota in Neurodegenerative Diseases

Implications of Gut Microbiota in Neurodegenerative Diseases

Historical and current perspectives on blood endothelial cell heterogeneity in the brain

Age-Related Hearing Loss: The Link between Inflammaging, Immunosenescence, and Gut Dysbiosis

Contact Info

Product

Resources

About