Age Related Inflammatory Characteristics of Coronary Artery Disease

Najib, Elias; Puranik, Rajesh; Duflou, Johan; Xia, Qiong; Bao, Shisan

doi:10.1016/j.hlc.2010.06.713

Cited by 1 publication

(1 citation statement)

References 21 publications

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“…Many studies have also detected T cells within carotid plaques (Kleindienst et al, ; Palma et al, ; de Boer et al, ; Chen et al, ; Erbel et al, ; Dietel et al, ; Rohm et al, ). Plaques of otherwise similar status in older patients contain higher levels of infiltrating T cells (Najib et al, ). Both macrophages and T cells are present in higher proportions in the fibrous cap of ruptured plaques (Falk, ; Lendon et al, ; van der Wal et al, ; Boyle, ; Otsuka et al, ).…”

Section: Atherosclerosis and The Adaptive Immune System In Patientsmentioning

confidence: 99%

Readapting the adaptive immune response – therapeutic strategies for atherosclerosis

Sage

Mallat

2017

British J Pharmacology

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Cardiovascular diseases remain a major global health issue, with the development of atherosclerosis as a major underlying cause. Our treatment of cardiovascular disease has improved greatly over the past three decades, but much remains to be done reduce disease burden. Current priorities include reducing atherosclerosis advancement to clinically significant stages and preventing plaque rupture or erosion. Inflammation and involvement of the adaptive immune system influences all these aspects and therefore is one focus for future therapeutic development. The atherosclerotic vascular wall is now recognized to be invaded from both sides (arterial lumen and adventitia), for better or worse, by the adaptive immune system. Atherosclerosis is also affected at several stages by adaptive immune responses, overall providing many opportunities to target these responses and to reduce disease progression. Protective influences that may be defective in diseased individuals include humoral responses to modified LDL and regulatory T cell responses. There are many strategies in development to boost these pathways in humans, including vaccine‐based therapies. The effects of various existing adaptive immune targeting therapies, such as blocking critical co‐stimulatory pathways or B cell depletion, on cardiovascular disease are beginning to emerge with important consequences for both autoimmune disease patients and the potential for wider use of such therapies. Entering the translation phase for adaptive immune targeting therapies is an exciting and promising prospect. Linked Articles This article is part of a themed section on Targeting Inflammation to Reduce Cardiovascular Disease Risk. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.22/issuetoc and http://onlinelibrary.wiley.com/doi/10.1111/bcp.v82.4/issuetoc

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