Age-related macular degeneration and cognitive impairment show similarities in changes of neutral lipids in peripheral blood mononuclear cells

Peiretti, Enrico; Mandas, Antonella; Abete, Claudia; Vinci, Michela; Piludu, Stefania; Casu, Maria Antonietta; Caminiti, Giulia; Dessı̀, Sandra; Fossarello, Maurizio

doi:10.1016/j.exer.2014.04.017

Cited by 9 publications

(7 citation statements)

References 34 publications

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“…Association with early macular degeneration and cognitive impairment was found only in an older population, suggesting that a pathophysiology is likely shared by macular degeneration and age-related brain diseases (Baker et al, 2009). The results of a previous study of ours were in apparent contrast: no cognitive impairment was found – as assessed by mini mental state examination – in a group of 136 macular degeneration patients admitted to the outpatient eye clinic of the University of Cagliari (Peiretti et al, 2014). However, these patients were younger and macular degeneration was not in an advanced stage.…”

Section: Discussioncontrasting

confidence: 74%

“…We found no evidence that statins confer protection against vision disorders or dementia (Peiretti et al, 2014). In disagreement with earlier reports (Hall et al, 2001; Baghdasarian et al, 2004), we found a definite positive association between statin use and the presence of dementia and vision disorders (Peiretti et al, 2014). In view of these many discrepancies, we conducted an observational study with the aim of: firstly, quantifying the association between the incidence and progression of age-related vision disorders and cognitive impairment; secondly, evaluating the impact of statin and aspirin use on different types of age-related vision and cognitive disorders.…”

Section: Introductioncontrasting

confidence: 55%

Section: Introductionmentioning

confidence: 71%

“…Data from a recent study of ours showed that macular degeneration patients present changes in lipid metabolism similar to those seen in Alzheimer’s disease ones, i.e., accumulation of neutral lipids in the cytoplasm of peripheral blood mononuclear cells (Peiretti et al, 2014). We found no evidence that statins confer protection against vision disorders or dementia (Peiretti et al, 2014). In disagreement with earlier reports (Hall et al, 2001; Baghdasarian et al, 2004), we found a definite positive association between statin use and the presence of dementia and vision disorders (Peiretti et al, 2014).…”

Section: Introductionmentioning

confidence: 71%

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Cognitive Impairment and Age-Related Vision Disorders: Their Possible Relationship and the Evaluation of the Use of Aspirin and Statins in a 65 Years-and-Over Sardinian Population

Mandas

Mereu

Catte

et al. 2014

Front. Aging Neurosci.

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Neurological disorders (Alzheimer’s disease, vascular and mixed dementia) and visual loss (cataract, age-related macular degeneration, glaucoma, and diabetic retinopathy) are among the most common conditions that afflict people of at least 65 years of age. An increasing body of evidence is emerging, which demonstrates that memory and vision impairment are closely, significantly, and positively linked and that statins and aspirin may lessen the risk of developing age-related visual and neurological problems. However, clinical studies have produced contradictory results. Thus, the intent of the present study was to reliably establish whether a relationship exist between various types of dementia and age-related vision disorders, and to establish whether statins and aspirin may or may not have beneficial effects on these two types of disorders. We found that participants with dementia and/or vision problems were more likely to be depressed and displayed worse functional ability in basic and instrumental activities of daily living than controls. Mini mental state examination scores were significantly lower in patients with vision disorders compared to subjects without vision disorders. A closer association with macular degeneration was found in subjects with Alzheimer’s disease than in subjects without dementia or with vascular dementia, mixed dementia, or other types of age-related vision disorders. When we considered the associations between different types of dementia and vision disorders and the use of statins and aspirin, we found a significant positive association between Alzheimer’s disease and statins on their own or in combination with aspirin, indicating that these two drugs do not appear to reduce the risk of Alzheimer’s disease or improve its clinical evolution and may, on the contrary, favor its development. No significant association in statin use alone, aspirin use alone, or the combination of these was found in subjects without vision disorders but with dementia, and, similarly, none in subjects with vision disorders but without dementia. Overall, these results confirm the general impression so far; namely, that macular degeneration may contribute to cognitive disorders (Alzheimer’s disease in particular). In addition, they also suggest that, while statin and aspirin use may undoubtedly have some protective effects, they do not appear to be magic pills against the development of cognitive impairment or vision disorders in the elderly.

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Section: Discussioncontrasting

confidence: 74%

Section: Introductioncontrasting

confidence: 55%

Section: Introductionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 71%

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Cognitive Impairment and Age-Related Vision Disorders: Their Possible Relationship and the Evaluation of the Use of Aspirin and Statins in a 65 Years-and-Over Sardinian Population

Mandas

Mereu

Catte

et al. 2014

Front. Aging Neurosci.

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“…Growing evidence in clinical and experimental studies strongly suggests involvement of Muller glia activation in the pathogenesis of the most common age-related eye disorders, including cataract, glaucoma, diabetic retinopathy and age-related macular degeneration. In addition, high CE levels, which tend to become oxidized into oxysterols, have also been reported in several eye lesions in particular, drusen and in ageing Bruch's membrane, which are all hallmark features of age-related macular degeneration [41][42][43].…”

Section: Hypertensionmentioning

confidence: 99%

Abnormal Lipid Accumulation and Cluster Formation of Naive Peripheral Blood Mononuclear Cells: A Useful Tool for Early Detection of Central Nervous System Damage in Elderly

Serchisu¹,

Peiretti²,

Costaggiu³

et al. 2017

J Alzheimers Dis Parkinsonism

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Incidence and Risk Factors of Reticular Pseudodrusen Using Multimodal Imaging

et al. 2020

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IMPORTANCE Although retinal multimodal imaging is needed for diagnosing reticular pseudodrusen (RPD), the incidence of RPD in the general population typically has been assessed only using fundus photographs, which may underestimate their incidence.OBJECTIVES To describe the incidence of RPD using retinal color photographs, spectral-domain optical coherence tomography scans, fundus autofluorescence, and near-infrared reflectance images among individuals 77 years of age or older and to analyze the associated risk factors of RPD. DESIGN, SETTING, AND PARTICIPANTSThe ALIENOR (Antioxydants, Lipides Essentiels, Nutrition et Maladies Oculaires) Study is a cohort of French individuals 77 years of age or older. Data for this study were collected between February 22, 2011, and February 15, 2017, with a mean (SD) follow-up of 3.7 (1.0) years (range, 1.2-5.6 years). At baseline, 501 individuals were eligible to participate. Of 1002 eyes, 197 had prevalent RPD, advanced age-related macular degeneration, or ungradable images. Of the remaining 805 eyes, 333 were missing follow-up data; therefore, the statistical analyses included data from 472 eyes. Data management and statistical analyses were performed between March 15, 2017, and April 5, 2019. MAIN OUTCOMES AND MEASURESReticular pseudodrusen were considered as present if detected by at least 2 of the following imaging methods: color fundus photographs, fundus autofluorescence, near-infrared reflectance, and spectral-domain optical coherence tomography images. RESULTSOf the 472 eyes analyzed, 263 (55.7%) were from female participants, and the mean (SD) age was 81.9 (3.2) years. Forty-three eyes developed RPD, corresponding to an annual incidence rate of 2.9% (95% CI, 1.9%-4.4%) per participant and an estimated 5-year risk of 13.5%. In multivariable analysis, 4 risk factors of incident RPD were identified: subfoveal choroidal thinning (hazard ratio [HR], 0.99; 95% CI, 0.99-1.00 per 10-μm decrease in thickness; P = .02) and the presence of the minor allelic variants rs10490924 for ARMS2 (HR, 3.57; 95% CI, 1.80-7.10; P < .001), rs1061170 for CFH (HR, 2.12; 95% CI, 1.02-4.41; P = .04), and rs10468017 for LIPC (HR, 2.57; 95% CI, 1.37-4.82; P = .003). Lipophilic statin therapy was associated with a lower incidence of RPD (HR, 0.13; 95% CI, 0.02-0.74; P = .02). CONCLUSIONS AND RELEVANCEWith the use of multimodal imaging, the RPD incidence rate was higher than previously reported in other population-based studies using fundus color images. Individuals with subfoveal choroidal thinning or carrying minor allelic variants for ARMS2, CFH, or LIPC had an increased risk for RPD, whereas lipophilic statin therapy was associated with a lower incidence.

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Age-related macular degeneration and cognitive impairment show similarities in changes of neutral lipids in peripheral blood mononuclear cells

Cited by 9 publications

References 34 publications

Cognitive Impairment and Age-Related Vision Disorders: Their Possible Relationship and the Evaluation of the Use of Aspirin and Statins in a 65 Years-and-Over Sardinian Population

Cognitive Impairment and Age-Related Vision Disorders: Their Possible Relationship and the Evaluation of the Use of Aspirin and Statins in a 65 Years-and-Over Sardinian Population

Abnormal Lipid Accumulation and Cluster Formation of Naive Peripheral Blood Mononuclear Cells: A Useful Tool for Early Detection of Central Nervous System Damage in Elderly

Incidence and Risk Factors of Reticular Pseudodrusen Using Multimodal Imaging

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