Age-Related Maturation of Wave V Latency of Auditory Brainstem Response in Children

Sharma, Mukesh; Bist, Sampan Singh; Kumar, Santosh

doi:10.7874/jao.2016.20.2.97

Cited by 28 publications

(21 citation statements)

References 16 publications

(22 reference statements)

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“…1, critical period). In rodents, the critical period extends from P10 to P14 (de Villers-Sidani et al, 2007) and in humans, it likely occurs between the 27th embryonic week and the sixth to 12th month after birth (Sharma et al, 2016).…”

Section: Tinnitus Occurs With Low Prevalence In Congenital Deafness Bmentioning

confidence: 99%

The Neural Bases of Tinnitus: Lessons from Deafness and Cochlear Implants

et al. 2020

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Subjective tinnitus is the conscious perception of sound in the absence of any acoustic source. The literature suggests various tinnitus mechanisms, most of which invoke changes in spontaneous firing rates of central auditory neurons resulting from modification of neural gain. Here, we present an alternative model based on evidence that tinnitus is: (1) rare in people who are congenitally deaf, (2) common in people with acquired deafness, and (3) potentially suppressed by active cochlear implants used for hearing restoration. We propose that tinnitus can only develop after fast auditory fiber activity has stimulated the synapse formation between fast-spiking parvalbumin positive (PV 1 ) interneurons and projecting neurons in the ascending auditory path and coactivated frontostriatal networks after hearing onset. Thereafter, fast auditory fiber activity promotes feedforward and feedback inhibition mediated by PV 1 interneuron activity in auditory-specific circuits. This inhibitory network enables enhanced stimulus resolution, attention-driven contrast improvement, and augmentation of auditory responses in central auditory pathways (neural gain) after damage of slow auditory fibers. When fast auditory fiber activity is lost, tonic PV 1 interneuron activity is diminished, resulting in the prolonged response latencies, sudden hyperexcitability, enhanced cortical synchrony, elevated spontaneous c oscillations, and impaired attention/stress-control that have been described in previous tinnitus models. Moreover, because fast processing is gained through sensory experience, tinnitus would not exist in congenital deafness. Electrical cochlear stimulation may have the potential to reestablish tonic inhibitory networks and thus suppress tinnitus. The proposed framework unites many ideas of tinnitus pathophysiology and may catalyze cooperative efforts to develop tinnitus therapies.

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Section: Tinnitus Occurs With Low Prevalence In Congenital Deafness Bmentioning

confidence: 99%

The Neural Bases of Tinnitus: Lessons from Deafness and Cochlear Implants

et al. 2020

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“…These patients eventually developed hearing loss issues after subsequent additional chemotherapy treatment [41]. Wave V is generated primarily from the inferior colliculus, which is the main midbrain nucleus of the auditory pathway [42,43]. During the first few years of life, wave V latency was found to change regularly where it decreased rapidly in early childhood [43].…”

Section: Discussionmentioning

confidence: 99%

“…Wave V is generated primarily from the inferior colliculus, which is the main midbrain nucleus of the auditory pathway [42,43]. During the first few years of life, wave V latency was found to change regularly where it decreased rapidly in early childhood [43]. This decrease in wave V latency could be attributed to rapid growth in the axonal myelin density in the brainstem pathways and the cochlear nerve during early childhood [42,43].…”

Section: Discussionmentioning

confidence: 99%

Sphingosine 1-Phosphate Receptor 2 Induces Otoprotective Responses to Cisplatin Treatment

Wang

Shanmugam

Xiang

et al. 2020

Cancers

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Ototoxicity is a major adverse effect of platinum-based chemotherapeutics and currently, there remains a lack of United States Food and Drug Administration-approved therapies to prevent or treat this problem. In our study, we examined the role of the sphingosine 1-phosphate receptor 2 (S1P2) in attenuating cisplatin-induced ototoxicity in several different animal models and cell lines. We found that ototoxicity in S1P2 knockout mice is dependent on reactive oxygen species (ROS) production and that S1P2 receptor activation with a specific agonist, CYM-5478, significantly attenuates cisplatin-induced defects, including hair cell degeneration in zebrafish and prolonged auditory brainstem response latency in rats. We also evaluated the cytoprotective effect of CYM-5478 across different cell lines and showed that CYM-5478 protects neural-derived cell lines but not breast cancer cells against cisplatin toxicity. We show that this selective protection of CYM-5478 is due to its differential effects on key regulators of apoptosis between neural cells and breast cancer cells. Overall, our study suggests that targeting the S1P2 receptor represents a promising therapeutic approach for the treatment of cisplatin-induced ototoxicity in cancer patients.

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“…In this study, longer wave latencies were found compared to our research. Because the value of the peak V latency varies among different age person (28). Our study was carried out with adults.…”

Section: Discussionmentioning

confidence: 99%

“…The hearing thresholds specified as dB nHL in ABR is not equal to behavioral thresholds determined as dB HL. As a result, it is suggested to use the correction factor when calculating BHT thresholds (dB HL) from the thresholds (nHL) determined by ABR (25,28). The correction factor, which is used to estimate behavioral hearing thresholds with using of NB CE-Chirp ABR, can be reduced by up to 5 dB (21,16).…”

Section: Discussionmentioning

confidence: 99%

Advantages of Narrow Band CE-Chirp ABR Compared to Tone Burst ABR in Adults with Normal Hearing

Ceylan

İşlek

Baba

et al. 2020

Preprint

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Objectives: In this study, we aimed to compare the ABR's (Auditory Brainstem Response) estimated behavioral thresholds, wave V latencies, and amplitudes, obtained using Tone Burst and Narrow Band (NB) CE-Chirp stimuli in adults with normal hearing. Design: A prospective study was designed. Setting: Otorhinolaryngology and Audiology Clinic of the tertiary university. Participants: Twenty-four adults with normal hearing (17 males, 7 females) participated in this study. Main outcome measures: ABR was recorded using Narrow Band (NB) CE-Chirp and Tone Burst (TB) for four frequencies (0.5, 1, 2, 4 kHz). Wave V obtained for 60, 40, and 20 dB nHL intensity levels for both two procedures. Behavioral hearing thresholds (BHT) were identified at 0.5, 1, 2, 4 kHz. Duration of TB and NB CE Chirp ABR tests for each ear was recorded. Wave V latencies, amplitudes, BHTs, duration of tests were compared. Results: The thresholds obtained from NB CE-Chirp stimulus (20,19,16,15 dB nHL) at 0.5, 1, 2 and 4 kHz were significantly closer to the behavioral hearing thresholds (11, 10, 9, 9 dB HL) compared to Tone Burst ABR thresholds (25, 23, 20, 19 dB nHL) (at all frequencies p < 0.001, CI = 2.0-5.9). The absolute latencies of peak V with TB stimuli were significantly longer than latencies obtained with NB CE Chirp stimuli at 0.5, 1, and 2 kHz at all sound intensity levels (p<0.001). The mean test time for NB CE-Chirp ABR was 23.6 ± 3.9 minutes and significantly shorter than the TB ABR test time (28.2 ± 4.5), (p=0.011). Conclusion: Frequency-specific behavioral thresholds are estimated better with NB CE-Chirp than TB ABR.

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Age-Related Maturation of Wave V Latency of Auditory Brainstem Response in Children

Cited by 28 publications

References 16 publications

The Neural Bases of Tinnitus: Lessons from Deafness and Cochlear Implants

The Neural Bases of Tinnitus: Lessons from Deafness and Cochlear Implants

Sphingosine 1-Phosphate Receptor 2 Induces Otoprotective Responses to Cisplatin Treatment

Advantages of Narrow Band CE-Chirp ABR Compared to Tone Burst ABR in Adults with Normal Hearing

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