Age-related mechanical strength evolution of trabecular bone under fatigue damage for both genders: Fracture risk evaluation

Kahla, Rabeb Ben; Barkaoui, Abdelwahed; Merzouki, Tarek

doi:10.1016/j.jmbbm.2018.05.006

Cited by 18 publications

(9 citation statements)

References 87 publications

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“…Bones can generate mechanical stresses due to physiological activities[36], they are mechanically and dynamically balanced [37].3D FEM is an effective method for studying complex craniofacial structures [38], which provides a complete description of the bone stress elds and is widely used to study bone mechanics [39]. FEM results are often shown in EQV stresses, i.e.…”

Section: Discussionmentioning

confidence: 99%

Three-dimensional Finite Element Analysis of the Effect of Alveolar Cleft Bone Graft on the Maxillofacial Biomechanical Stabilities of Unilateral Complete Cleft Lip and Palate

Tian

Huang

Shi

et al. 2021

Preprint

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Background: The objective was to clarify the effect of alveolar cleft bone graft on maxillofacial biomechanical stabilities, the key areas when bone grafting and in which should be supplemented with bone graft once bone resorption occurred in UCCLP (Unilateral Complete Cleft Lip and Palate).Methods: Maxillofacial CAD (Computer Aided Design) models of non-bone graft and full maxilla cleft, full alveolar cleft bone graft, bone graft in other sites of the alveolar cleft were acquired by processing the UCCLP maxillofacial CT data in three-dimensional modeling softwares. The maxillofacial bone equivalent (EQV) stresses and bone suture EQV strains under occlusal states were obtained in the finite element analysis software.Results: Under corresponding occlusal states, the EQV stresses of maxilla, pterygoid process of sphenoid bone on the corresponding side and anterior alveolar arch on the non-cleft side were higher than other maxillofacial bones, the EQV strains of nasomaxillary, zygomaticomaxillary and pterygomaxillary suture on the corresponding side were higher than other maxillofacial bone sutures. The mean EQV strains of nasal raphe, the maximum EQV stresses of posterior alveolar arch on the non-cleft side, the mean and maximum EQV strains of nasomaxillary suture on the non-cleft side in full alveolar cleft bone graft model were all significantly lower than those in non-bone graft model. The mean EQV stresses of bilateral anterior alveolar arches, the maximum EQV stresses of maxilla and its alveolar arch on the cleft side in the model with bone graft in lower 1/3 of the alveolar cleft were significantly higher than those in full alveolar cleft bone graft model.Conclusions: For UCCLP, bilateral maxillae, pterygoid processes of sphenoid bones and nasomaxillary, zygomaticomaxillary, pterygomaxillary sutures, anterior alveolar arch on the non-cleft side are the main occlusal load bearing structures before and after alveolar cleft bone graft. Alveolar cleft bone graft mainly affects biomechanical stabilities of nasal raphe and posterior alveolar arch, nasomaxillary suture on the non-cleft side. The areas near nasal floor and in the middle of the alveolar cleft are the key sites when bone grafting, and should be supplemented with bone graft when the bone resorbed in these areas.

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Section: Discussionmentioning

confidence: 99%

Three-dimensional Finite Element Analysis of the Effect of Alveolar Cleft Bone Graft on the Maxillofacial Biomechanical Stabilities of Unilateral Complete Cleft Lip and Palate

Tian

Huang

Shi

et al. 2021

Preprint

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“…MHT has become the leading therapeutic choice for preserving bone health in early postmenopausal women. The spine often experiences the biggest loss the one year before finishing the last period and the beginning of the first two to three years following menopause [10,11].…”

Section: Introductionmentioning

confidence: 99%

The Relationship of Osteoporosis with Menopause: Review of Article

Alsarraje¹,

Alhyali²

2022

IJRMST

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Osteoporosis is the most problem of women's bone disease, it has a multitude of causes, including menopause. It affects about one in three women. Before a fracture, osteoporosis does not exhibit any clinical symptoms. Important pathology is brought on by fractures. Postmenopausal osteoporosis can be avoided with early diagnosis of this condition before fractures happen; Menopausal hormone therapy (MHT) significantly reduces the fracture risk in all body bones by halting bone loss and degeneration of bone microstructure. The fast bone loss brought on by declining estrogen peaks in the first two to three years following menopause. Even in women with modest fracture risk, MHT is the only antiosteoporosis medication that has been shown to be effective regardless of baseline risk . There is no rationale for using specific, efficient drugs to treat osteoporosis, making MHT the first option for maintaining bone health in women. It is also advisable to evaluate the advantages and risks of MHT. MHT has become the leading therapeutic choice for preserving bone health in early postmenopausal women.

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“…Several factors are influencing bone development such as biological factors, endocrine factors, physical activity, diseases, genetic factors, race, gender etc. (Barkaoui et al,2017;Ben Kahla et al,2018;Ait oumghar et al, 2020;Ben Kahla et al, 2021).The human bone development study remains a vast subject of research because of the lack of experimental data results. Although, the full regulatory mechanisms of (BMUs) are not yet established, which makes the formulation of several cellular models more complex.…”

Section: Introductionmentioning

confidence: 99%

Bone Remodeling Model Integrating the Biological Function and Damage Influences for the Cortical-Trabecular Interface

Soltani

Oumghar²,

Barkaoui

et al. 2021

JER is an international, peer-reviewed journal that publishes f

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Bone remodeling process has been widely investigated in literature from an experimental and theoretical viewpoint. Indeed, the biological process of bone remodeling allows a continuous renewal of the microstructure over time and thus, it contributes to decrease the bone damage by repairing it. This research work aims to study the biological function’s (fbio) effects on the bone remodeling process trough bone density evolution. Parameter fbio is one of the important parameters that controls bone volume variation. The biological bone remodeling process is modeled in terms of equations describing the activity of the Basic Multi-cellular Units (BMU). We use a mathematical model to simulate damage repair, based on Garcia Aznar’s model. The results of simulation show a good match with experimental and clinical data: bone porosity decreases over time and decreases also as the biological factors increase. In the same view, the apparent density (ρa) decreases with bone volume fraction increases. We note that the governance of the evolution of bone density leads to consider the evolution of bone volume during youthful and the maturation phase with their saturation zone for adult in terms of growth.

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Age-related mechanical strength evolution of trabecular bone under fatigue damage for both genders: Fracture risk evaluation

Cited by 18 publications

References 87 publications

Three-dimensional Finite Element Analysis of the Effect of Alveolar Cleft Bone Graft on the Maxillofacial Biomechanical Stabilities of Unilateral Complete Cleft Lip and Palate

Three-dimensional Finite Element Analysis of the Effect of Alveolar Cleft Bone Graft on the Maxillofacial Biomechanical Stabilities of Unilateral Complete Cleft Lip and Palate

The Relationship of Osteoporosis with Menopause: Review of Article

Bone Remodeling Model Integrating the Biological Function and Damage Influences for the Cortical-Trabecular Interface

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