Age-related Menory Impairment and Hippocampal Damage in ddY Male Mice

Tanaka, Masahiro; Asanuma, Akimune; Ikuta, Junya; Yamada, Hideki; Shimizu, Sota; Koga, Teruji; Kakishita, Tomofumi

doi:10.1538/expanim1978.43.5_697

Cited by 7 publications

(4 citation statements)

References 13 publications

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“…The CA1 region of the hippocampus has been reported to have a reduced density of CA1 neurons in AD patients after dementia and stroke [ 11 ]. Furthermore, the CA3 region has been reported to be vulnerable to aging, and the number of cells per unit area decreases with aging [ 45 ]. In addition, a decrease in the number of granule cells in the DG has been reported in an animal model of diabetes [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Pathophysiological features in the brains of female Spontaneously Diabetic Torii (SDT) fatty rats

Maekawa

Sugimoto

Kume

et al. 2022

The Journal of Veterinary Medical Science

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Diabetes mellitus (DM) and obesity are associated with neurodegenerative diseases such as Alzheimer's disease and psychiatric disorders such as major depression. In this study, we investigated pathophysiological changes in the brains of female spontaneously diabetic torii (SDT) fatty rats with diabetes and obesity. Brains of SD, SDT and SDT fatty rats were collected at 58 weeks of age. The parietal cortical thickness was measured and the number of pyramidal cells in the hippocampal cornu ammonis 1 and 3 (CA1 and CA3) and the number of granule cells in the dentate gyrus (DG) regions were counted. The area of glial fibrillary acidic protein (GFAP) positivity in CA1, CA3 and DG regions were measured. The parietal cortical thickness and the number of cells in CA3 and DG regions of SDT and SDT fatty rats did not show obvious changes. On the other hand, in the CA1 region, the number of cells in SDT rats and SDT fatty rats was significantly lower than that in SD rats, and that in SDT fatty rats was significantly lower than that in SDT rats. The GFAP-positive area in SDT fatty rats was significantly reduced compared to that in SD rats only in the DG region. Preliminarily result showed that the expression of S100a9, an inflammation-related gene, was increased in the brains of SDT fatty rats. These results suggest that female SDT fatty rat may exhibit central nervous system diseases due to obesity and DM.

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Section: Discussionmentioning

confidence: 99%

Pathophysiological features in the brains of female Spontaneously Diabetic Torii (SDT) fatty rats

Maekawa

Sugimoto

Kume

et al. 2022

The Journal of Veterinary Medical Science

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“…The CA1 region of the hippocampus is reportedly a site in which CA1 neuronal density volume is reduced in patients with dementia and AD post-stroke, or ischemic vascular disease [ 10 ]. Furthermore, the CA3 region is reportedly weak against aging, and the number of cells per unit area decreases due to aging [ 38 ]. Reductions in nerve density in the hippocampal region of BB/W rats in a type 1 DM model [ 21 ] and reductions in nerve density of the prefrontal cortex in BBZDR/Wor rats in a T2DM model [ 20 ] have been reported.…”

Section: Discussionmentioning

confidence: 99%

Pathophysiological abnormalities in the brains of Spontaneously Diabetic Torii-<i>Lepr <sup>fa</sup></i> (SDT fatty) rats, a novel type 2 diabetic model

Maekawa

Ohta

Kume

2018

The Journal of Veterinary Medical Science

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In recent years, a relationship between diabetes and neurodegenerative diseases, such as Parkinson’s disease, Alzheimer disease or depression, has been proposed. In this study, pathophysiological changes in the brain, especially in the hippocampus, of male SDT fatty rats with obesity and hyperglycemia were investigated. Brains of SD rats and SDT fatty rats were collected at 32 and 58 weeks of age, and parietal cortical thickness and number of pyramidal cells in the hippocampal cornu ammonis 1 and 3 (CA1 and CA3) regions were measured. At 58 weeks of age, the parietal cortical thickness and number of pyramidal cells in the hippocampal CA1 and CA3 regions were lower in SDT fatty rats than in age-matched SD rats. Measurements of mRNA in rat brains at 58 weeks of age showed that the expression of genes related to inflammatory responses (S100a9, TNFα, NF-κB) was elevated in SDT fatty rats. From the aforementioned results, changes suggestive of brain atrophy and impairment in cognitive function were observed in male SDT fatty rat brains.

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“…Decrease and atrophy of pyramidal cells in the CA1 and CA3 regions have been associated with the deterioration of memory ability [27]. Therefore, we assessed the number of pyramidal cells in the CA1 and CA3 regions of the hippocampus.…”

Section: Discussionmentioning

confidence: 99%

Molar loss and powder diet leads to memory deficit and modifies the mRNA expression of brain-derived neurotrophic factor in the hippocampus of adult mice

et al. 2016

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BackgroundIt is known that tooth loss is known to be a risk factor for Alzheimer’s disease and soft diet feeding induces memory impairment. Recent studies have shown that brain-derived neurotrophic factor (BDNF) is associated with tooth loss or soft diet in young animal model, and that BDNF expression is decreased in patients with Alzheimer’s disease. However, single or combined effect of tooth loss and/or soft diet on brain function has not fully understood. Here we examined the effect of molar loss and powder diet on memory ability and the expression of BDNF mRNA in the hippocampus of adult C57BL/6J mice. Twenty eight-weeks-old C57BL/6J mice were divided into intact molar group and extracted molar group. They were randomly divided into the I/S group (Intact upper molar teeth/Solid diet feeding), the E/S group (Extracted upper molar teeth/Solid diet feeding), the I/P group (Intact upper molar teeth/Powder diet feeding), and the E/P group (Extracted upper molar teeth/Powder diet feeding). The observation periods were 4 and 16-week. To analyze the memory ability, the step-through passive avoidance test was conducted. BDNF-related mRNA in the hippocampus was analyzed by real-time polymerase chain reaction (RT-PCR).ResultsAt 4 weeks later, we performed memory test and isolated brains to analyze. There were no differences in memory function and BDNF mRNA level between these four groups. However, at 16 weeks later, E/S and E/P group showed memory impairment, and decreased level of BDNF mRNA. Whereas, the powder diet had no effect on memory function and BDNF mRNA level even at 16 weeks later.ConclusionsThese results suggest that the effect of molar loss and powder diet on memory function and BDNF mRNA levels were different, molar loss may have a greater long-term effect on memory ability than powder diet does.

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Age-related Menory Impairment and Hippocampal Damage in ddY Male Mice

Cited by 7 publications

References 13 publications

Pathophysiological features in the brains of female Spontaneously Diabetic Torii (SDT) fatty rats

Pathophysiological features in the brains of female Spontaneously Diabetic Torii (SDT) fatty rats

Pathophysiological abnormalities in the brains of Spontaneously Diabetic Torii-<i>Lepr <sup>fa</sup></i> (SDT fatty) rats, a novel type 2 diabetic model

Molar loss and powder diet leads to memory deficit and modifies the mRNA expression of brain-derived neurotrophic factor in the hippocampus of adult mice

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