1990
DOI: 10.1016/0047-6374(90)90024-a
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Age-related modifications of cytochrome c oxidase activity in discrete brain regions

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Cited by 65 publications
(15 citation statements)
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“…Therefore, perturbations in mitochondria that lead to alterations in oxidative phosphorylation have particular relevance with respect to neurodegeneration. In support of the notion that oxidative phosphorylation is associated with disease processes are the findings that respiratory activity and mitochondrial complex IV activity are reduced in the aged rat brain (Harmon, et al, 1987;Curti, et al, 1990), and that the activities of mitochondrial complexes I and IV have been reported to be attenuated in aged rat muscle (Torii, et al, 1992). Additionally, experiments on non-human primate brains showed that there were agerelated changes in the activities of complexes I and IV which correlate with a decrease in ATP production (Bowling, et al, 1993).…”
Section: Introductionmentioning
confidence: 56%
“…Therefore, perturbations in mitochondria that lead to alterations in oxidative phosphorylation have particular relevance with respect to neurodegeneration. In support of the notion that oxidative phosphorylation is associated with disease processes are the findings that respiratory activity and mitochondrial complex IV activity are reduced in the aged rat brain (Harmon, et al, 1987;Curti, et al, 1990), and that the activities of mitochondrial complexes I and IV have been reported to be attenuated in aged rat muscle (Torii, et al, 1992). Additionally, experiments on non-human primate brains showed that there were agerelated changes in the activities of complexes I and IV which correlate with a decrease in ATP production (Bowling, et al, 1993).…”
Section: Introductionmentioning
confidence: 56%
“…Although the bulk of dry matter of inner mitochondria1 membrane is protein (Harmon et al, 1974), a direct relationship exists between amount of negatively charged phospholipids and catalytic activity of cytochrome oxidase (Vik and Capaldi, 1977;Fry and Green, 1980;Casanovas et al, 1985). During aging the decrease in the cytochrome oxidase activity (Abu-Erreish and Sanadi, 1978;Benzi, 1979;Benzi et al, 1980) may be induced by both decrease in the number of cytochrome aa3 molecules (Curti et al, 1990) and/or changes in membrane lipid composition (Sun and Sun, 1979). Choline-labeled phosphatidylcholine is largely absorbed across the jejunum and the amount of lymphatic transport of radioactivity is 17% at 8 hr after oral administration.…”
Section: Discussionmentioning
confidence: 97%
“…Recently, the repercussions of mitochondrial Ca 2 /energy compromise on ER Ca 2 homeostasis have been demonstrated, the former leading to impaired ER Ca 2 release and uptake (Landol® et al, 1998). In ageing rodent and primate brain, energy production may be less eective, even de®cient in response to metabolic stress (Bertoni-Freddari et al, 1996), due to an impaired mitochondrial glucose oxidation and oxidative phosphorylation (Bowling et al, 1993;Ferrandiz et al, 1994), a decline of cytochrome oxidase activity (Curti et al, 1990;Sohal, 1993), and a reduced Ca 2 -mediated activation of pyruvate dehydrogenase (Bogonez et al, 1992). Moreover, ROS release of mitochondria increases with ageing (Sohal and Sohal, 1991), and presumably as a consequence of oxidative stress the electron transport chain has a lower activity and induction of the mitochondrial PT is enhanced (Zhang et al, 1990;Goodell and Cortopassi, 1998).…”
Section: Ageing and Energy Homeostasismentioning
confidence: 98%