Age related neurodegenerative Alzheimer’s disease: Usage of traditional herbs in therapeutics

Singh, A. K.; Agarwal, Sindhu; Singh, Sarika

doi:10.1016/j.neulet.2019.134679

Cited by 11 publications

(7 citation statements)

References 77 publications

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“…[ 1 , 2 , 3 , 4 ]. In particular, neurodegenerative disease in the brain is known to be caused by abnormalities of neurons, and the basic research studies on the detailed mechanisms are at different levels of progress [ 3 , 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Profiling and Identification of Omeprazole Metabolites in Mouse Brain and Plasma by Isotope Ratio-Monitoring Liquid Chromatography-Mass Spectrometric Method

Shin

Park

et al. 2020

Life

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Neuro–inflammation is known to be one of the pathogenesis for the degenerative central nervous system (CNS) disease. Recently various approaches for the treatment of brain diseases by controlling neuro-inflammation in the brain have been introduced. In this respect, there is a continuous demand for CNS drugs, which could be safer and more effective. Omeprazole, a well-known proton-pump inhibitor (PPI) is generally prescribed for the treatment of peptic ulcer. In addition to the anti-gastric acid secretion mechanism, recent studies showed that omeprazole or PPIs would likely have anti-inflammation effects in vitro and in vivo, but their effects on anti-inflammation in brain are still unknown. In this study, omeprazole and its metabolites in a mouse’s brain after various routes of administration have been explored by stable isotope ratio-patterning liquid chromatography–mass spectrometric method. First, a simple liquid chromatography–mass spectrometric (LC–MS) method was established for the quantification of omeprazole in mouse plasma and brain. After that, omeprazole and its stable isotope (D3–omeprazole) were concomitantly administered through various routes to mice in order to identify novel metabolites characteristically observed in the mouse brain and were analyzed using a different LC–MS method with information-dependent analysis (IDA) scan. With this unique approach, several new metabolites of omeprazole were identified by the mass difference between omeprazole and stable isotope in both brain and plasma samples. A total of seventeen metabolites were observed, and the observed metabolites were different from each administration route or each matrix (brain or plasma). The brain pharmacokinetic profiles and brain-to-plasma partition coefficient (Kp) were also evaluated in a satellite study. Overall, these results provide better insights to understand the CNS-related biological effects of omeprazole and its metabolites in vivo.

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Section: Introductionmentioning

confidence: 99%

Profiling and Identification of Omeprazole Metabolites in Mouse Brain and Plasma by Isotope Ratio-Monitoring Liquid Chromatography-Mass Spectrometric Method

Shin

Park

et al. 2020

Life

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“…In a recent study, it was proved that MFSE was effective in controlling memory de icits in Alzheimer's disease (Singh et al, 2020). This research study indicated that MFSE treated groups exhibited signi icant improvement in suitable reactions during T-maze test, a substantial reduction in duration to board the hidden stage in the MWM test and TL in the EPM test.…”

Section: Discussionmentioning

confidence: 77%

“…MFSE were illustrated to enhance the cognitive and intellectual abilities in rats (Jissa et al, 2014). MF extract was capable of reducing acetylcholinesterase activity which is more bene icial in the treatment of Alzheimer's disease (Singh et al, 2020). Nutmeg oil was evidenced to be effective in the management of epilepsy (Ayaz et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Aromatic spice Nutmeg attenuates memory deficits in Rotenone model of Parkinson’s disease

K¹,

Prabhu

Rajasankar

2020

ijrps

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PD is a multifactorial neurodegenerative disorder with features such as tremor, rigidity, bradykinesia, postural instability, and dementia. Neuropathologically, selective loss or death of dopaminergic neurons is the hallmark of PD. In PD, elevated oxidative stress, mitochondrial dysfunction and neuroinflammation were reported. Rotenone (an isoflavone obtained from Fabaceae associated vegetation such as the jicama vine plant) induces oxidative stress, mitochondrial dysfunction, inflammation and apoptosis in cell line and animal models. It was useful in the evaluation of neuroprotective properties on cell line and animal models of PD. Drugs with anti-oxidant potential helped to control the cellular stress, free radical formation, neurotransmitter level in PD animal models. Nutmeg, an aromatic spice exhibited memory enhancing, anti-oxidant, anticonvulsant properties. It is an excellent body detoxifier and stimulator of the brain due to the presence of pharmacologically active compounds such as eugenol, isoelemicin, isoeugenol, methoxyeugenol, myristic acid, myristicin, saponins and lignin. Macelignan (a compound present in nutmeg) having the low molecular weight and hydrophobic nature could pass beyond the blood-brain barrier. In this study, we explored the cognitive profile of rotenone-induced model of PD treated with MFSE extract (MFSE) by behavioural tests (Morris water maze test, T-maze test and Elevated plus maze Test). Rotenone was injected to male Wistar albino rats by intra-peritoneal route (2.5mg/kg daily) for 30days. MFSE treated rats showed significant improvement in cognition in rotenone-induced PD model. It might be due to its neuroprotective and anti-cholinesterase properties.

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“…Alzheimer’s disease (AD) is the most common progressive and devastating disease of the elderly that is related to cognition impairment [ 1 ]. The pathological features of AD include amyloid beta (Aβ) deposition and intracellular neurofibrillary tangles (NFT) containing hyperphosphorylated tau protein, as well as loss of synapses and neurons [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Echinacoside Improves Cognitive Impairment by Inhibiting Aβ Deposition Through the PI3K/AKT/Nrf2/PPARγ Signaling Pathways in APP/PS1 Mice

Qiu

Liu

2022

Mol Neurobiol

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Echinacoside (ECH), a phenylethanoid glycoside, has protective activity in neurodegenerative disease, including anti-inflammation and antioxidation. However, the effects of ECH in Alzheimer’s disease (AD) are not very clear. This present study investigates the role and mechanism of ECH in the pathological process of AD. APP/PS1 mice treated with ECH in 50 mg/kg/day for 3 months. Morris water maze, nesting test, and immunofluorescence staining used to observe whether ECH could improve AD pathology. Western blot used to study the mechanism of ECH improving AD pathology. The results showed that ECH alleviated the memory impairment of APP/PS1 mice by reducing the time of escape latency as well as increasing the times of crossing the platform and rescued the impaired ability to construct nests. In addition, ECH significantly reduced the deposition of senile plaques in the brain and decreased the expression of BACE1 in APP/PS1 mice through activating PI3K/AKT/Nrf2/PPARγ pathway. Furthermore, ECH decreased ROS formation, GP91 and 8-OHdG expression, upregulated the expression of SOD1 and SOD2 as well as activating the PI3K/AKT/Nrf2 signaling pathway. Moreover, ECH inhibited glia cells activation, pro-inflammatory cytokine IL-1β and TNF-α release, NLRP3 inflammasome formation through TXNIP/Trx-1 signaling pathway. In conclusion, this paper reported that ECH improved cognitive function, inhibited oxidative stress, and inflammatory response in AD. Therefore, we suggest that ECH may considered as a potential drug for AD treatment.

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Age related neurodegenerative Alzheimer’s disease: Usage of traditional herbs in therapeutics

Cited by 11 publications

References 77 publications

Profiling and Identification of Omeprazole Metabolites in Mouse Brain and Plasma by Isotope Ratio-Monitoring Liquid Chromatography-Mass Spectrometric Method

Profiling and Identification of Omeprazole Metabolites in Mouse Brain and Plasma by Isotope Ratio-Monitoring Liquid Chromatography-Mass Spectrometric Method

Aromatic spice Nutmeg attenuates memory deficits in Rotenone model of Parkinson’s disease

Echinacoside Improves Cognitive Impairment by Inhibiting Aβ Deposition Through the PI3K/AKT/Nrf2/PPARγ Signaling Pathways in APP/PS1 Mice

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