Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study

Andriollo-Sanchez, M; Hininger‐Favier, Isabelle; Meunier, Nathalie; Venneria, Eugenia; O’Connor, Jacqueline M.; Maiani, Giuseppe; Coudray, Charles; Roussel, Anne‐Marie

doi:10.1038/sj.ejcn.1602300

Cited by 122 publications

(79 citation statements)

References 27 publications

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“…In a practical test, the method confirmed previous studies showing increased oxidative stress associated with age [1,[23][24][25].…”

Section: Discussionsupporting

confidence: 75%

“…GSH/GSSG steady-state redox potential was also significantly (p<0.01) more reduced in young (−155.1 ± 4.2 mV) than in older (−121.2 ± 4.4 mV) adults (Fig 4c) due mainly to decreased GSH concentrations in older adults. These data are consistent with previous findings and confirm the utility of the new method for evaluation of relevant steady-state redox potential differences for use as a clinical measurement of oxidative stress in humans [1,[23][24][25].…”

Section: Evaluation Of Plasma Thiol/disulfide Oxidative Stress With Agesupporting

confidence: 81%

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A rapid LC-FTMS method for the analysis of cysteine, cystine and cysteine/cystine steady-state redox potential in human plasma

Johnson

Strobel

Reed

et al. 2008

Clinica Chimica Acta

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Background-The steady-state redox potential of the cysteine/cystine couple in human plasma provides a measure of oxidative stress, yet available assays are limited by either specificity or speed of assay.Method-The present study evaluated the use of LC-FTMS for identification based on accurate mass combined with quantification by stable isotopic dilution to rapidly determine cysteine and cystine concentration and cysteine/cystine steady-state redox potential in human plasma.Results-A simple extraction procedure followed by a rapid LC separation eluted cysteine in 4 min and cystine in 1.5 min with simultaneous measurement of glutathione (GSH) and glutathione disulfide (GSSG). A study of five young (mean age = 25.7) subjects and 5 older (mean age = 67.8 y) subjects showed an increased oxidation with age.Conclusions-Analysis by LC-FTMS is suitable for high-throughput analysis of plasma cysteine, cystine and cysteine/cystine steady-state redox potential as clinical measures of oxidative stress.

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“…In a practical test, the method confirmed previous studies showing increased oxidative stress associated with age [1,[23][24][25].…”

Section: Discussionsupporting

confidence: 75%

Section: Evaluation Of Plasma Thiol/disulfide Oxidative Stress With Agesupporting

confidence: 81%

A rapid LC-FTMS method for the analysis of cysteine, cystine and cysteine/cystine steady-state redox potential in human plasma

Johnson

Strobel

Reed

et al. 2008

Clinica Chimica Acta

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show abstract

“…malondialdehyde (MDA), reduced glutathione and membrane-SH groups , NO , superoxide dismutase (SOD)and catalase , glutathione-S-transferase (GST) , glutathione peroxidise activity (GPx) , and a significant age dependent decline in plasma antioxidant capacity, measured in terms of ferric reducing ability of plasma (FRAP) values (Rizvi et al,2006). A similar study on European subjects showed a highly significant correlation between sensitivity and early markers of oxidative stress and aging (Andriollo-Sanchez et al, 2005). A significant correlation between the decline in total antioxidant capacity of plasma and age associated increase in protein carbonyls (PCO), advanced oxidation protein products (AOPPs) and loss in plasma thiol groups (T-SH) content in Indian population was demonstrated (Pandey et al, 2010).…”

Section: Agingmentioning

confidence: 86%

“…According to the free radical theory (Harman, 1994), an increase in generation of free radicals and oxidative stress is responsible for age related deterioration and disorders. Though small amounts of oxidative damage keep occurring even normally, the rate of this damage increases with the aging process, with the decline in antioxidative (Andriollo-Sanchez et al, 2005) and repair mechanisms (Inal et al,2001). In several studies, oxidative damage as a function of age has been reported.…”

Section: Agingmentioning

confidence: 99%

Role of tea catechins in prevention of aging and age-related disorders

Khanna¹,

Maurya²

2012

TANG [HUMANITAS MEDICINE]

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Tea polyphenols especially catechins have long been studied for their antioxidant and radical scavenging properties. Scientists throughout the world have investigated the usefulness of the regular green tea consumption in several disease conditions. In-vitro and in-vivo experiments on catechins especially epigallocatechingallate have revealed a significant role in many ways. Reactive oxygen species have been increasingly implicated in the pathogenesis of many diseases and important biological processes. Toxic effects of these oxidants, commonly referred to as oxidative stress, can cause cellular damage by oxidizing nucleic acids, proteins, and membrane lipids. Oxidative stress has been related to aging and age related disorders. It is found that in a wide variety of pathological processes, including cancer, atherosclerosis, neurological degeneration, Alzheimer's disease, ageing and autoimmune disorders, oxidative stress has its implications. Catechins have been reported to be useful in combating aging and age related disorders like cancer, cardiovascular disorders and neurodegenerative diseases. In this mini review we will discuss such studies done across the globe.

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“…15,16 The prevalence of the latter mechanism would be unable to explain the age attributed increase in GGT levels in older patients.…”

mentioning

confidence: 99%

Quo Vadis: From Oxidative Stress to Gamma-Glutamyltransferase Upregulation to Mortality

Mehta

Birerdinc

Younossi

2013

Journal of Clinical and Experimental Hepatology

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Serum levels of the hepatobiliary enzyme gamma-glutamyltransferase or gamma-glutamyl transpeptidase (GGT) have recently been associated with hepatic involvement of patients with atherosclerotic cardiovascular disease (CVD). 1À3 In the current issue of JCEH, Loomba et al. 4 report a study showing that elevated serum GGT (>51 U/L in men and >33 U/L in women) seems to be an independent predictor of CVD, liver mortality and all-cause mortality in older adults (mean age 70 years). These observations were made in a prospective study of 2,364 individuals. The study results indicate that individuals with elevated GGT were more likely to be obese, hypertensive with higher systolic blood pressure, dyslipidemic, and diabetic. These risk factors are associated with the profile of an individual with metabolic syndrome who may have a very high likelihood of having underlying non-alcoholic fatty liver disease (NAFLD).In the last 5 year, there has been a renewed interest in serum GGT as an indicator of chronic diseases such as NAFLD, metabolic syndrome, CVD as well as other chronic heart diseases such as congestive heart failure. 5 In the upper reference range, GGT has been found to be an independent biomarker of metabolic syndrome (abnormal body mass index and levels of high-density lipoprotein (HDL) cholesterol, glucose, triglycerides, and systolic and diastolic blood pressure), with a 20% per GGT quartile trend rise. 6 As noted previously, GGT maybe a marker of an underlying subclinical liver disease, especially, NAFLD. This is supported by the association of a number of risk factors with GGT such as glucose, insulin resistance, cholesterol, HDL, low-density lipoprotein (LDL), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). 7,8 These risk factors are however, not independent and are clustered and associated with each other. The risk factors are also associated with metabolic syndrome and its hepatic manifestation, NAFLD. In this case, adjustment for the presence of the above mentioned risk factors should decrease the strength of association of GGT with mortality. Interestingly, adjustment for the associated risk factors does not fully account for the association seen between GGT and mortality. 8,9 This is also shown in the study by Loomba et al. 4 All together, these data suggest that GGT, indeed, might directly relate to certain pathogenetic processes that may involve the liver as well as other organs, rather than being a simple co-correlate of other clinical variable.The key to untangling this relationship is in understanding the enzymatic function of GGT. This enzyme catalyzes the transfer of the gamma-glutamyl moiety of its major substrate-glutathione (GSH) to an acceptor that may be an amino acid, a peptide or water (forming glutamate), thus playing an important role in the homeostasis of GSH. It is located on the cell surface and by breaking down of extracellular GSH, it provides the rate limiting substrate-cysteine, for intracellular de novo synthesis of GSH. 10 The GGT mediated cleavage of GSH, ...

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Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study

Cited by 122 publications

References 27 publications

A rapid LC-FTMS method for the analysis of cysteine, cystine and cysteine/cystine steady-state redox potential in human plasma

A rapid LC-FTMS method for the analysis of cysteine, cystine and cysteine/cystine steady-state redox potential in human plasma

Role of tea catechins in prevention of aging and age-related disorders

Quo Vadis: From Oxidative Stress to Gamma-Glutamyltransferase Upregulation to Mortality

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