Age‐related patterns of urinary Gonadotropins (FSH and LH) and E‐3‐G as measures of reproductive function among Turkana Males of Northern Kenya

Leslie, Paul W.; Campbell, Kenneth L.

doi:10.1080/19485565.2006.9989115

Cited by 4 publications

(3 citation statements)

References 48 publications

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“…40 In contrast, urinary FSH and LH levels among Turkana men of Kenya showed increases in well-fed sedentary men but not undernourished nomads. 41 Moreover, average LH and FSH levels were significantly higher among well-fed settled versus undernourished nomadic Turkana men. However, caution is warranted when interpreting urinary gonadotropin levels in response to undernutrition because urinary levels of LH and FSH increase significantly without concurrent changes in serum levels in response to fasting in men, suggesting altered renal clearance that is independent of pituitary production.…”

Section: Sex Hormone Variationmentioning

confidence: 90%

“…E-3-G levels were positively associated with age in the settled well-fed population. 41 Follicle stimulating hormone (FSH) and LH are gonadotropins produced by the pituitary under control of gonadotropin-releasing hormone (GnRH) from the hypothalamus. FSH is involved with spermatogenesis whereas LH stimulates testosterone production.…”

Section: Sex Hormone Variationmentioning

confidence: 99%

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An evolutionary and life history perspective on human male reproductive senescence

Bribiescas

2010

Annals of the New York Academy of Sciences

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Unlike menopause, male reproductive senescence does not involve an acute drop in fertility. Men do, however, manifest distinct changes in somatic and gonadal function with age. Moreover, population variation in male reproductive senescence reveals phenotypic plasticity resulting from environmental, lifestyle, and genetic factors. An evolutionary and life history perspective is vital for understanding male reproductive senescence because aging involves biological constraint as well as adjustments to reproductive strategies and the allocation of somatic resources. An awareness of life history-related tradeoffs between energetic and time constraints is especially useful because biological aspects of male senescence are products of environmental challenges and natural selection. This article reviews the adaptive significance of the evolutionary biology of human male senescence with particular attention to population variation. An evolutionary perspective cannot only shed light on the origins and biology of human male senescence but also provide insights into contemporary issues of male aging and health.

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Section: Sex Hormone Variationmentioning

confidence: 90%

Section: Sex Hormone Variationmentioning

confidence: 99%

An evolutionary and life history perspective on human male reproductive senescence

Bribiescas

2010

Annals of the New York Academy of Sciences

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“…However, work from small‐scale and non‐Western societies have found that some age‐related physiological processes, including cardiovascular function and hormone levels, thought to be inevitable, may in fact not be (Ellison et al, ; Gurven, Blackwell, Eid Rodríguez, Stieglitz, & Kaplan, ; Kaplan et al, ; Kurita et al, ; Mueller, Noya‐Alarcon, Contreras, Appel, & Dominguez‐Bello, ; Raichlen et al, ; Uchida et al, ). When lifestyle, nutrition, energetic status, and population variation of biomarker levels have been explored, the biological inevitability of senescence as exhibited in Western populations comes into question (Campbell, Leslie, & Campbell, , ; Ellison et al, ; Uchida et al, ).…”

Section: Introductionmentioning

confidence: 99%

Age‐related decline in urine concentration may not be universal: Comparative study from the U.S. and two small‐scale societies

Rosinger

Pontzer

Raichlen

et al. 2019

American J Phys Anthropol

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Objectives: Evidence from industrialized populations suggests that urine concentrating ability declines with age. However, lifestyle factors including episodic protein intake and low hypertension may help explain differences between populations. Whether this age-related decline occurs among small-scale populations with active lifestyles and non-Western diets is unknown. We test the universality of age-related urine concentration decline. Materials and Methods: We used urine specific gravity (Usg) and urine osmolality (Uosm) data from 15,055 U.S. nonpregnant adults without kidney failure aged 18-80 in 2007-2012 participating in the National Health and Nutrition Examination Survey (NHANES). We tested the relationship of age on urine concentration biomarkers with multiple linear regressions using survey commands. We compared results to longitudinal data on Usg from 116 Tsimane' foragerhorticulturalists (266 observations) adults aged 18-83 in 2013-2014 from Lowland Bolivia, and to 38 Hadza hunter-gatherers (156 observations) aged 18-75 in 2010-2015 from Tanzania using random-effects panel linear regressions.Results: Among U.S. adults, age was significantly negatively associated with Usg (Adjusted beta [B] = −0.0009 g/mL/10 years; SE = 0.0001; p < 0.001) and Uosm (B = −28.1 mOsm/kg/10 yr; SE = 2.4; p < 0.001). In contrast, among Tsimane' (B = 0.0003 g/mL/10 yr; SE = 0.0002; p = 0.16) and Hadza (B = −0.0004 g/mL/10 yr; SE = 0.0004; p = 0.29) age was not associated with Usg. Older Tsimane' and Hadza exhibited similar within-individual variability in Usg equivalent to younger adults.Discussion: While U.S. adults exhibited age-related declines in urine concentration, Tsimane' and Hadza adults did not exhibit the same statistical decline in Usg. Mismatches between evolved physiology and modern environments in lifestyle may affect kidney physiology and disease risk. K E Y W O R D S aging, kidney physiology, lifestyle mismatch, urine concentration

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Recent Research on the Human Biology of Pastoralists

Campbell

2024

American J Hum Biol

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Despite encroachment by agricultural systems and globalization, pastoral nomads maintain a robust presence in terms of numbers and subsistence activity. At the same time, increasing concern about climate change has promoted awareness that increased climatic fluctuation may push pastoral population past their capacity for resilience. The response of pastoralists to climate change has important implications for our evolutionary past and our increasingly problematic future. Yet, pastoralists have received less explicit attention than foragers as populations under consistent selective constraints including limited caloric intake, high levels of habitual activity, and high disease burdens. Additional factors include exposure to cold and high temperatures, as well as high altitude. Over the last 20 or so years, the use of new techniques for measuring energetics, including actigraphs and doubly labeled water have built on existing noninvasive sample collection for hormones, immune markers and genes to provide a more detailed picture of the human biology of pastoral populations. Here I consider recent work on pastoralists from Siberia and northern Europe, Africa, Asia, and South America. I survey what is known about maternal milk composition and infant health, childhood growth, lactase persistence, and adult energy expenditure and lactase persistence to build a picture of the pastoralist biological response to environmental conditions, including heat, cold, and high altitude. Where available I include information about population history because of its importance for selection. I end by outlining the impact of milk consumption and climate over the human life cycle and make suggestions for further research.

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Age‐related patterns of urinary Gonadotropins (FSH and LH) and E‐3‐G as measures of reproductive function among Turkana Males of Northern Kenya

Cited by 4 publications

References 48 publications

An evolutionary and life history perspective on human male reproductive senescence

An evolutionary and life history perspective on human male reproductive senescence

Age‐related decline in urine concentration may not be universal: Comparative study from the U.S. and two small‐scale societies

Recent Research on the Human Biology of Pastoralists

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