Age-related reduction of myocardial metabolic efficiency: Is it time to routinely measure myocardial metabolism to monitor cardiac health?

Fragasso, Gabriele

doi:10.1136/heartjnl-2017-311729

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…On the other hand, could these people be labelled as having chronic heart failure (HFpEF)? Nevertheless, in this context, cardiac MRS with 31P spectroscopy for PCr/ATP ratio determination could represent a very useful tool to better characterize otherwise healthy elderly patients in terms of prognostic stratification [ 31 ]. However, aging is by itself an unsuccessful process.…”

Section: Age-related Myocardial Remodellingmentioning

confidence: 99%

The Concept of "Heart Failure with Preserved Ejection Fraction": Time for a Critical Reappraisal

Fragasso¹

2023

Rev. Cardiovasc. Med.

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Heart failure with preserved ejection fraction (HFpEF) is frequently observed in elderly physically deconditioned subjects, mainly women with hypertension, obesity, glucose intolerance/diabetes, atrial fibrillation, anaemia, coronary artery disease, chronic pulmonary disease, and chronic renal insufficiency. In practice, these conditions represent the majority of cardiac diseases we deal with in our daily clinical practice. For this reason, the HFpEF disease does not exist as a single entity and, as such, no specific unifying therapy could be found. New classification attempts still do not consider the multifaceted aspect of the HF syndrome and appear rather as an artefactual attempt to categorize a condition which is indeed not categorizable. The aim of the present article is to critically review the construction of the concept of the HFpEF syndrome and propose the return of a pathophysiological approach in the evaluation and treatment of patients. Considering the huge economic efforts employed up to date to run awfully expensive trials and research in this field, it is time to call action and redirect such resources towards more specific pathophysiological classifications and potential specific therapeutic targets.

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Section: Age-related Myocardial Remodellingmentioning

confidence: 99%

The Concept of "Heart Failure with Preserved Ejection Fraction": Time for a Critical Reappraisal

Fragasso¹

2023

Rev. Cardiovasc. Med.

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“…In the accompanying editorial, Fragasso2 discusses the parallels between the ageing changes in cardiac metabolism described in the study by Nathania et al 1 and the relationship between PCr/ATP ratios and cardiac function in patients with heart failure. He asks the questions: “Could the described age-related cardiac metabolic phenotype be the pathophysiological basis of heart failure with preserved ejection fraction?” “Could we do something to slow down this apparently irremediable age-related process?” Although these questions remain unanswered, Fragasso suggests that we should “monitor cardiac metabolic levels and try to improve them by effectively dealing with pathological conditions that could be deleterious and adopt healthy lifestyles.…”

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confidence: 99%

Heartbeat: Age-related changes in the cardiac response to exercise

Nakatani

Otto

2018

Heart

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Mitochondria and Calcium Homeostasis: Cisd2 as a Big Player in Cardiac Ageing

Yeh

Chou

Kao

et al. 2020

IJMS

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The ageing of human populations has become a problem throughout the world. In this context, increasing the healthy lifespan of individuals has become an important target for medical research and governments. Cardiac disease remains the leading cause of morbidity and mortality in ageing populations and results in significant increases in healthcare costs. Although clinical and basic research have revealed many novel insights into the pathways that drive heart failure, the molecular mechanisms underlying cardiac ageing and age-related cardiac dysfunction are still not fully understood. In this review we summarize the most updated publications and discuss the central components that drive cardiac ageing. The following characters of mitochondria-related dysfunction have been identified during cardiac ageing: (a) disruption of the integrity of mitochondria-associated membrane (MAM) contact sites; (b) dysregulation of energy metabolism and dynamic flexibility; (c) dyshomeostasis of Ca2+ control; (d) disturbance to mitochondria–lysosomal crosstalk. Furthermore, Cisd2, a pro-longevity gene, is known to be mainly located in the endoplasmic reticulum (ER), mitochondria, and MAM. The expression level of Cisd2 decreases during cardiac ageing. Remarkably, a high level of Cisd2 delays cardiac ageing and ameliorates age-related cardiac dysfunction; this occurs by maintaining correct regulation of energy metabolism and allowing dynamic control of metabolic flexibility. Together, our previous studies and new evidence provided here highlight Cisd2 as a novel target for developing therapies to promote healthy ageing

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Age-related reduction of myocardial metabolic efficiency: Is it time to routinely measure myocardial metabolism to monitor cardiac health?

Cited by 3 publications

References 8 publications

The Concept of "Heart Failure with Preserved Ejection Fraction": Time for a Critical Reappraisal

The Concept of "Heart Failure with Preserved Ejection Fraction": Time for a Critical Reappraisal

Heartbeat: Age-related changes in the cardiac response to exercise

Mitochondria and Calcium Homeostasis: Cisd2 as a Big Player in Cardiac Ageing

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