Age-Related Reduction of Systemic Arterial Compliance Induces Excessive Myocardial Oxygen Consumption during Sub-Maximal Exercise

Abstract

Reduction of systemic arterial compliance (SAC) with aging increases left ventricular afterload. The present study was designed to examine whether age-related reduction of SAC is related to excessive myocardial oxygen consumption during sub-maximal aerobic exercise. We studied elderly (60-69 years; n =25) and senior (70-82 years; n =25) subjects. We measured SAC immediately before the start of the ramp-fashion exercise (i.e., at the end of the 20 W warm-up exercise) and the double product (DP: systolic blood pressure heart rate) during the ramp-fashion exercise (20-50 W). SAC was significantly lower in senior subjects

Acute Exercise Increases Systemic Arterial Compliance after 6-Month Exercise Training in Older Women

“…A decreased central arterial distensibility results in an (22,26). It has been reported that acute exercise induces an increase in arterial distensibility in young humans (14,27).…”

“…A carotid arterial waveform has been used as the central arterial waveform to esti- mate SAC non-invasively (10). In the present study, a finger arterial waveform was transformed to a brachial arterial waveform using analysis software (Beatscope; TNO-BMI, Amsterdam, the Netherlands) (20,21); the transformed arterial waveform was used to calculate SAC instead of the carotid arterial waveform (22,23). We estimated SV using the Modelflow method from the transformed arterial waveform using Beatscope (24,25).…”

Blood Pressure Regulation During Bathing: Is There a Cardiovascular Risk?

“…Again, we demonstrated a linear relationship between carotid arterial PWV and cardiovagal BRS. It is well-established that arterial stiffness increases with advancing age (Avolio et al, 1985;Otsuki et al, 2006a;Otsuki et al, 2006b;Vaitkevicius et al, 1993). Central arterial stiffness are also associated with daily physical activities (Iemitsu et al, 2006;Sugawara et al, 2006).…”

Age-Related Reduction of Systemic Arterial Compliance Relates to Decreased Aerobic Capacity during Sub-Maximal Exercise

“…Takeshi OTSUKI 1) , Seiji MAEDA 1), 2) , Jun SUGAWARA 3) , Yumiko KESEN 2) , Haruka MURAKAMI 4) , Takumi TANABE 1) , Takashi MIYAUCHI 1), 5) , Shinya KUNO 2) , Ryuichi AJISAKA 2) , and Mitsuo MATSUDA 1) A decrease in systemic arterial compliance (SAC) increases left ventricular load along with the demand for excessive myocardial oxygen consumption when the age-related reduction of SAC reaches a marked level, and consequently may depress left ventricular pump function. Reduced left ventricular pump function decreases aerobic capacity, and some study groups have shown that SAC and/or central arterial distensibility is correlated with maximal aerobic capacity in humans.…”

“…, double product: SBP × heart rate) during sub-maximal aerobic exercise (5). However, the relationship of arterial compliance and double product remains not significant until the reduction of arterial compliance reaches a marked level (5).…”