Age-Related Reductions in Tactile and Motor Inhibitory Function Start Early but Are Independent

Ruitenberg, M.F.L.; Cassady, Kaitlin; Reuter‐Lorenz, Patricia A.; Tommerdahl, Mark; Seidler, Rachael D.

doi:10.3389/fnagi.2019.00193

Cited by 14 publications

(19 citation statements)

References 54 publications

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“…Although we observed a relationship between age differences in motor and somatosensory neural representations in the current study, we did not observe a relationship between motor and tactile behavioral measures, either in the present study or in our previous study (Ruitenberg et al 2019). One reason for this discrepancy between the neural and behavioral relationships may be that tactile stimulation during fMRI scanning was passive, whereas the (outside of scanner) tactile behavioral tasks were active.…”

Section: Age Differences In Somatosensory System Are Related To Age Differences In Motor Systemcontrasting

confidence: 98%

“…The results from the motor tapping task have been reported previously in our previous study (Ruitenberg et al 2019). In short, we observed that age significantly predicted the intrahemispheric between-finger lag, such that increasing age was associated with an increased duration of the between-finger lag (B = 2.22, t = 4.14, P < 0.001).…”

Section: Motor Tapping Performancesupporting

confidence: 89%

“…The results from the (out-of-scanner) tactile tasks were consistent with those reported in Ruitenberg et al 2019; please refer to this paper for more detailed results and corresponding figures. Regression analyses with age as the independent variable and general tactile processing measures as the dependent variables showed that older age was associated with declines in RTs (simple: B = 1.67, t = 3.16, P = 0.003; choice: B = 6.94, t = 3.54, P = 0.001) as well as static thresholds (B = 0.11, t = 5.34, P < 0.001).…”

Section: Tactile Performancesupporting

confidence: 88%

“…Thirty-seven healthy participants (21 females; 16 males) ranging in age from 19 to 76 years (mean = 43.7 ± 17.3) were recruited for this study. These participants were also included as part of a larger sample from our previous study in which we analyzed motor and somatosensory behavioral data (Ruitenberg et al 2019). All participants were right-handed and had normal or corrected hearing and vision.…”

Section: Participantsmentioning

confidence: 99%

“…Previous studies have demonstrated that somatosensory (i.e., vibrotactile) processing declines with age (Zhang et al 2011). In addition, our group recently demonstrated that inter and intrahemispheric inhibition also declines with age in the somatosensory system (Ruitenberg et al 2019). Whether this age difference in surround inhibition (or somatosensory performance in general) is associated with differences in somatosensory neural representations remains an open question.…”

Section: Introductionmentioning

confidence: 99%

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Neural Dedifferentiation across the Lifespan in the Motor and Somatosensory Systems

et al. 2020

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Age-related declines in sensorimotor performance have been linked to dedifferentiation of neural representations (i.e., more widespread activity during task performance in older versus younger adults). However, it remains unclear whether changes in neural representations across the adult lifespan are related between the motor and somatosensory systems, and whether alterations in these representations are associated with age declines in motor and somatosensory performance. To investigate these issues, we collected functional magnetic resonance imaging and behavioral data while participants aged 19–76 years performed a visuomotor tapping task or received vibrotactile stimulation. Despite one finding indicative of compensatory mechanisms with older age, we generally observed that 1) older age was associated with greater activity and stronger positive connectivity within sensorimotor and LOC regions during both visuomotor and vibrotactile tasks; 2) increased activation and stronger positive connectivity were associated with worse performance; and 3) age differences in connectivity in the motor system correlated with those in the somatosensory system. Notwithstanding the difficulty of disentangling the relationships between age, brain, and behavioral measures, these results provide novel evidence for neural dedifferentiation across the adult lifespan in both motor and somatosensory systems and suggest that dedifferentiation in these two systems is related.

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Section: Age Differences In Somatosensory System Are Related To Age Differences In Motor Systemcontrasting

confidence: 98%

Section: Motor Tapping Performancesupporting

confidence: 89%

Section: Tactile Performancesupporting

confidence: 88%

Section: Participantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neural Dedifferentiation across the Lifespan in the Motor and Somatosensory Systems

et al. 2020

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Healthy Human Laryngopharyngeal Sensory Innervation Density Correlates with Age

Cole

Perry

et al. 2022

The Laryngoscope

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Objective Somatosensory feedback from upper airway structures is essential for swallowing and airway defense but little is known about the identities and distributions of human upper airway neurons. Furthermore, whether sensory innervation modifies with aging is unknown. In this study, we quantify neuronal and chemosensory cell density in upper airway structures and correlate with age. Methods Participants underwent biopsies from base of tongue, lateral and midline pharyngeal wall, epiglottis, and arytenoids (N = 25 13 female/12 male; 20–80 years, mean 51.4 years without clinical diagnosis of dysphagia or clinical indication for biopsy). Tissue sections were labeled with antibodies for all neurons, myelinated neurons, and chemosensory cells. Densities of lamina propria innervation, epithelial innervation, solitary chemosensory cells, and taste buds were calculated and correlated with age. Results Arytenoid had the highest density of innervation and chemosensory cells across all measures compared to other sites. Taste buds were frequently observed in arytenoid and epiglottis. Base of tongue, lateral pharynx, and midline posterior pharynx had minimal innervation and few chemosensory cells. Epithelial innervation was present primarily in close proximity to chemosensory cells and taste buds. Overall innervation and myelinated fibers in the arytenoid lamina propria decline with aging. Conclusion Findings establish the architecture of healthy adult sensory innervation and demonstrate the varied distribution of laryngopharyngeal innervation, necessary steps toward understanding the sensory basis for swallowing and airway defense. We also document age‐related decline in arytenoid innervation density. These findings suggest that sensory afferent denervation of the upper airway may be a contributing factor to presbyphagia. Level of Evidence NA Laryngoscope, 133:773–784, 2023

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Developmental and age differences in visuomotor adaptation across the lifespan

Ruitenberg

Koppelmans

Seidler

et al. 2023

Psychological Research

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In the present cross-sectional study, we examined age and sex differences in sensorimotor adaptation. We tested 253 individuals at a local science museum (NEMO Science Museum, Amsterdam). Participants spanned a wide age range (8–70 years old; 54% male), allowing us to examine effects of both development and healthy aging within a single study. Participants performed a visuomotor adaptation task in which they had to adapt manual joystick movements to rotated visual feedback. We assessed the rate of adaptation following the introduction of the visual perturbation (both for early and later stages of adaptation), and the rate of de-adaptation following its removal. Results showed reliable adaptation patterns which did not differ by sex. We observed a quadratic relationship between age and both early adaptation and de-adaptation rates, with younger and older adults exhibiting the fasted adaptation rates. Our findings suggest that both younger and older age are associated with poorer strategic, cognitive processes involved in adaptation. We propose that developmental and age differences in cognitive functions and brain properties may underlie these effects on sensorimotor functioning.

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Age-Related Reductions in Tactile and Motor Inhibitory Function Start Early but Are Independent

Cited by 14 publications

References 54 publications

Neural Dedifferentiation across the Lifespan in the Motor and Somatosensory Systems

Neural Dedifferentiation across the Lifespan in the Motor and Somatosensory Systems

Healthy Human Laryngopharyngeal Sensory Innervation Density Correlates with Age

Developmental and age differences in visuomotor adaptation across the lifespan

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