Age-related relationships between muscle fat content and metabolic traits in growing rabbits

Gondret, Florence; Hocquette, Jean-François; Herpin, Patrick

doi:10.1051/rnd:2004011

Cited by 23 publications

(18 citation statements)

References 41 publications

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“…These results confirm the general view that mitochondria in skeletal muscles can undergo rapid changes as a consequence of modifications in environmental conditions (Hoppeler and Martin, 2003). Generally, muscle fat content variation has been proven to result from a reciprocal balance between catabolic and anabolic fatty acid fluxes, and cannot be assigned to one specific energy pathway (Gondret et al, 2004).…”

Section: Implications For Product Qualitysupporting

confidence: 85%

Responses to nutrients in farm animals: implications for production and quality

Hocquette

Tesseraud

Cassar-Malek

et al. 2007

Animal

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It is well known that any quantitative (energy and protein levels) and qualitative (nature of the diet, nutrient dynamic) changes in the feeding of animals affect metabolism. Energy expenditure and feed efficiency at the whole-body level, nutrient partitioning between and within tissues and organs and, ultimately, tissue and organ characteristics are the major regulated traits with consequences on the quality of the meat and milk produced. Recent progress in biology has brought to light important biological mechanisms which explain these observations: for instance, regulation by the nutrients of gene expression or of key metabolic enzyme activity, interaction and sometimes cross-regulation or competition between nutrients to provide free energy (ATP) to living cells, indirect action of nutrients through a complex hormonal action, and, particularly in herbivores, interactions between trans-fatty acids produced in the rumen and tissue metabolism. One of the main targets of this nutritional regulation is a modification of tissue insulin sensitivity and hence of insulin action. In addition, the nutritional control of mitochondrial activity (and hence of nutrient catabolism) is another major mechanism by which nutrients may affect body composition and tissue characteristics. These regulations are of great importance in the most metabolically active tissues (the digestive tract and the liver) and may have undesirable (i.e. diabetes and obesity in humans) or desirable consequences (such as the production of fatty liver by ducks and geese, and the production of fatty and hence tasty meat or milk with an adapted fatty acid profile).

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Section: Implications For Product Qualitysupporting

confidence: 85%

Responses to nutrients in farm animals: implications for production and quality

Hocquette

Tesseraud

Cassar-Malek

et al. 2007

Animal

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“…However, in some studies, neither LPL and lipogenic enzymes in cattle (Bonnet et al, 2007), nor oxidative and lipogenic enzymes in pigs were shown to be related to IMF variation. First, IMF accumulation during growth is the result of a balance between fatty acids synthesis into adipocytes and their oxidation within muscle fibres, rather than upregulation of a single pathway in mammals (Gondret et al (2004a) in rabbits, Kolditz et al (2009) in fish); the turnover of fatty acids within the muscle must be considered. This assumption has been recently confirmed with the demonstration that muscle with a high IMF content displays a low adenosine monophosphateactivated protein kinase (AMP-K) activity compared with low-fat muscle.…”

Section: How Might Marbling Begin?mentioning

confidence: 99%

“…Then, the relationships between IMF content and metabolic markers could depend on the source of variation in IMF. This is the reason why some authors have preferred to combine both blood indicators and metabolic enzyme activities to predict IMF variability, but the equations of prediction differ between muscles (Gondret et al, 2004a). Furthermore, because enzymes of the same metabolic pathway (for instance, in mitochondria) are sometimes largely unrelated (Gondret et al, 2004b), it is important to combine different metabolic markers.…”

Section: How Might Marbling Begin?mentioning

confidence: 99%

Intramuscular fat content in meat-producing animals: development, genetic and nutritional control, and identification of putative markers

Hocquette

Gondret

Baéza³

et al. 2010

Animal

656

447

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Intramuscular fat (IMF) content plays a key role in various quality traits of meat. IMF content varies between species, between breeds and between muscle types in the same breed. Other factors are involved in the variation of IMF content in animals, including gender, age and feeding. Variability in IMF content is mainly linked to the number and size of intramuscular adipocytes. The accretion rate of IMF depends on the muscle growth rate. For instance, animals having a high muscularity with a high glycolytic activity display a reduced development of IMF. This suggests that muscle cells and adipocytes interplay during growth. In addition, early events that influence adipogenesis inside the muscle (i.e proliferation and differentiation of adipose cells, the connective structure embedding adipocytes) might be involved in interindividual differences in IMF content. Increasing muscularity will also dilute the final fat content of muscle. At the metabolic level, IMF content results from the balance between uptake, synthesis and degradation of triacylglycerols, which involve many metabolic pathways in both adipocytes and myofibres. Various experiments revealed an association between IMF level and the muscle content in adipocyte-type fatty acid-binding protein, the activities of oxidative enzymes, or the delta-6-desaturase level; however, other studies failed to confirm such relationships. This might be due to the importance of fatty acid fluxes that is likely to be responsible for variability in IMF content during the postnatal period rather than the control of one single pathway. This is evident in the muscle of most fish species in which triacylglycerol synthesis is almost zero. Genetic approaches for increasing IMF have been focused on live animal ultrasound to derive estimated breeding values. More recently, efforts have concentrated on discovering DNA markers that change the distribution of fat in the body (i.e. towards IMF at the expense of the carcass fatness). Thanks to the exhaustive nature of genomics (transcriptomics and proteomics), our knowledge on fat accumulation in muscles is now being underpinned. Metabolic specificities of intramuscular adipocytes have also been demonstrated, as compared to other depots. Nutritional manipulation of IMF independently from body fat depots has proved to be more difficult to achieve than genetic strategies to have lipid deposition dependent of adipose tissue location. In addition, the biological mechanisms that explain the variability of IMF content differ between genetic and nutritional factors. The nutritional regulation of IMF also differs between ruminants, monogastrics and fish due to their digestive and nutritional particularities.

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“…The development of intramuscular fat has been associated with fatty acid oxidation and ATP synthesis that occurs in muscle tissue (3). Previous studies have suggested that the intramuscular fat content in rabbits and sheep was due to a balance between catabolism and anabolism rather than a specific biochemical pathway (4,5). However, others have reported a significant correlation between intramuscular fat content and the mitochondrial enzymes cytochrome c oxidase and isocitrate dehydrogenase (6).…”

Section: Introductionmentioning

confidence: 99%

Proteome analysis of the m. longissimus dorsi between fattening stages in Hanwoo steer

Kim

Lee²,

Cho³

et al. 2009

BMB Reports

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The objective of this study was to identify proteins in the m. longissimus dorsi between early (12 months of age) and late (27 months of age) fattening stages of Hanwoo (Korean cattle) steers. Using two-dimensional electrophoresis and mass spectrometry, 8 proteins of 11 differentially expressed spots between the 12 and 27 month age groups were identified in the loin muscle. Among those that were differentially expressed, zinc finger 323 and myosin light chain were highly expressed in late-fattening stage, and two catabolic enzymes, triosephosphate isomerase (TPI) and succinate dehydrogenase (SDH) were expressed more in the early versus the late-fattening stage. In particular, the quantification of TPI and SDH by immunoblotting correlated well with fat content. Our data suggested that TPI and SDH are potential candidates as markers and their identification provides new insight into the molecular mechanisms and pathways associated with intramuscular fat contents of bovine skeletal muscle. [BMB reports 2009; 42(7): 433-438]

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Age-related relationships between muscle fat content and metabolic traits in growing rabbits

Cited by 23 publications

References 41 publications

Responses to nutrients in farm animals: implications for production and quality

Responses to nutrients in farm animals: implications for production and quality

Intramuscular fat content in meat-producing animals: development, genetic and nutritional control, and identification of putative markers

Proteome analysis of the m. longissimus dorsi between fattening stages in Hanwoo steer

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