Age-related scopolamine effects on social and individual behaviour in rats

Soffié, Monique; Bronchart, Marie

doi:10.1007/bf00181945

Cited by 26 publications

(13 citation statements)

References 40 publications

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“…These observations agree with those of the present study, showing that social grooming was the major pattern of interaction in both control and asphyxiated rats after isolation for 1 week. Furthermore, social grooming has been reported to increase with age, while antagonistic interactions, including fighting, decreased [20]. A similar pattern has been described by Albonetti and Farabollini [21], reporting that after single and repeated restraint, their rats showed decreased fighting behavior paralleled by an increased allogrooming as an appeasing behavior.…”

Section: Discussionsupporting

confidence: 56%

Long-Term Influence of Perinatal Asphyxia on the Social Behavior in Aging Rats

Weitzdoerfer

Gerstl²,

Pollak³

et al. 2004

Gerontology

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Background: Various groups have been addressing the question of whether perinatal asphyxia (PA) affects the behavior of young animals, but no information is available on long-term effects of PA on the behavior in aged rats, although it has been postulated that PA may lead to neurological and psychiatric deficits in adult life. Objective: We, therefore, decided to study the effects of PA on social and anxiety-related behaviors in 2-year-old rats, using a noninvasive animal model resembling the clinical situation. Methods: For the behavioral studies, the open-field test, the elevated plus-maze test, and a social interaction test in pairs were performed. Magnetic resonance imaging of the brain was selected to rule out neuropathological changes due to the aging process per se, as well as asphyxia-induced pathologies in the brain areas known to play an important role in the modulation of behavior. Results: The social interaction test revealed a statistically significant increase in the number of social grooming episodes and the time spent running alone, whereas the numbers of social sniffing and fighting episodes and the time spent running together were decreased in the asphyxiated group. The elevated plus- maze test revealed a higher presence of entries into the closed arm. Furthermore, sniffing and self-grooming episodes were significantly increased in the asphyxiated group. Conclusions: We found a significantly decreased social aggressiveness and an increased social contact behavior as well as increased anxiety levels in the asphyxiated animals. The present findings may provide important information on the long-term behavioral sequelae of PA in the aged individual.

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Section: Discussionsupporting

confidence: 56%

Long-Term Influence of Perinatal Asphyxia on the Social Behavior in Aging Rats

Weitzdoerfer

Gerstl²,

Pollak³

et al. 2004

Gerontology

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“…Given experimental findings suggesting that different forms of social behavior may be mediated by different neural systems [1,29,35] and, hence, may be differentially sensitive to social deprivation and variations in familiarity of the test situation, each form of social behavior was analyzed separately. Overall social activity, social investigation, contact behavior, and play fighting, as well as coefficient of social preference/avoidance and overall locomotor activity in the social context (total number of crossovers) were examined in the experimental subjects by using separate 4 (age) × 2 (housing condition) × 2 (test situation) × 2 (sex) analyses of variance (ANOVAs).…”

Section: Discussionmentioning

confidence: 99%

“…Most studies also used only an overall measure of social behavior (i.e., overall time spent in social interactions), even though the elementary behavioral acts summed together for these assessments (e.g., sniffing, grooming, chasing, following, crawling under or over, nape attacks, boxing, and wrestling) reflect separable and differentially regulated forms of interactive social behaviors that include social investigation, contact behavior, and play fighting. Each of these forms of social activity has a distinct ethological and ontogenetic pattern [17,20,32,35,39] and is affected differentially by drug treatments [1,29,35]. For instance, the ontogeny of play fighting demonstrates an inverted U-shaped pattern, with a peak being observed around P30-35 [18,19,20,35,39], whereas social investigation is more pronounced in adult than adolescent animals [37].…”

Section: Introductionmentioning

confidence: 99%

Social interactions in adolescent and adult Sprague–Dawley rats: Impact of social deprivation and test context familiarity

Varlinskaya

Spear

2008

Behavioural Brain Research

190

161

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Interactions with peers become particularly important during adolescence, and age differences in social interactions have been successfully modeled in rats. To determine the impact of social deprivation on social interactions under anxiogenic (unfamiliar) or non-anxiogenic (familiar) test circumstances during ontogeny, the present study used a modified social interaction test to assess the effects of 5 days of social isolation or group housing on different components of social behavior in early [postnatal day (P) 28], mid (P35), or late (P42) adolescent and adult (P70) male and female Sprague-Dawley rats. As expected, testing in an unfamiliar environment suppressed social interactions regardless of age, housing, and sex. Social deprivation drastically enhanced all forms of social behavior in P28 animals regardless of test situation, whereas depriving older animals of social interactions had more modest effects and was restricted predominantly to play fighting-an adolescent-characteristic form of social interactions. Social investigation-more adult-typical form of social behavior was relatively resistant to isolation-induced enhancement and was elevated in early adolescent isolates only. These findings confirm that different forms of social behavior are differentially sensitive to social deprivation across ontogeny.

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“…Studies have demonstrated that aged rodents exhibit alterations in a number of behavioral domains, including impaired cognitive function (Barrientos et al, 2012; Foster, 2012; Gallagher and Rapp, 1997; Nomura and Okuma, 1999; Rosenzweig and Barnes, 2003), increased anxietylike (Boguszewski and Zagrodzka, 2002; Darwish et al, 2001; Frussa-Filho et al, 1991; Hunt et al, 2011; Imhof et al, 1993; Miyagawa et al, 1998) and depressive-like behaviors (Kiss et al, 2012; Moretti et al, 2011), decreased locomotor activity (Gage et al, 1984; Godbout et al, 2008; Hunt et al, 2011), and importantly, impaired social interaction (Andersen et al, 1999; Hunt et al, 2011; Markel et al, 1995; Mencio-Wszalek et al, 1992; Salchner et al, 2004; Shoji and Mizoguchi, 2011; Soffié and Bronchart, 1988). Aged male rats (14–30-months-old) have been reported to exhibit reduced play behavior (Soffié and Bronchart, 1988), fewer social interactions (Markel et al, 1995; Salchner et al, 2004), less social investigation (Andersen et al, 1999), and to engage in less contact with conspecifics (Hunt et al, 2011) relative to adolescent or young adult rats (1.5–6-months-old).…”

Section: 0 Introductionmentioning

confidence: 99%

“…Aged male rats (14–30-months-old) have been reported to exhibit reduced play behavior (Soffié and Bronchart, 1988), fewer social interactions (Markel et al, 1995; Salchner et al, 2004), less social investigation (Andersen et al, 1999), and to engage in less contact with conspecifics (Hunt et al, 2011) relative to adolescent or young adult rats (1.5–6-months-old). Importantly, these aging-related social deficits are ubiquitous across many rat strains, including the Wistar (Andersen et al, 1999; Hunt et al, 2011; Markel et al, 1995; Soffié and Bronchart, 1988), Sprague-Dawley (Salchner et al, 2004), and Fischer 344/Brown Norway cross strains rats (Shoji and Mizoguchi, 2011), yet to our knowledge, only one study has examined potential sex differences in social behavior in aged animals. Hunt et al (2011) found that aged male and female Wistar rats (22–30 months) exhibited similar reductions in interaction with a novel age- and sex- matched social partner.…”

Section: 0 Introductionmentioning

confidence: 99%

A working model for the assessment of disruptions in social behavior among aged rats: The role of sex differences, social recognition, and sensorimotor processes

Perkins

Doremus-Fitzwater

Spencer

et al. 2016

Experimental Gerontology

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Aging results in a natural decline in social behavior, yet little is known about the processes underlying these changes. Engaging in positive social interaction is associated with many health benefits, including reduced stress reactivity, and may serve as a potential buffer against adverse consequences of aging. The goal of these studies was to establish a tractable model for the assessment of social behavior deficits associated with late aging. Thus, in Exp. 1, 1.5-, 3-, and 18-month-old male Fischer 344 (F344) rats were assessed for object investigation, and social interaction with a same-aged partner (novel/familiar), or a different-aged partner, thereby establishing working parameters for studies that followed. Results revealed that 18-month-old males exhibited reductions in social investigation and social contact behavior, with this age-related decline not influenced by familiarity or age of the social partner. Subsequently, Exp. 2 extended assessment of social behavior to both male and female F344 rats at multiple ages (3, 9, 18, and 24 months), after which a series of sensorimotor performance tests were conducted. In this study, both males and females exhibited late aging-related reductions in social interactions, but these changes were more pronounced in females. Additionally, sensorimotor performance was shown to be impaired in 24-month-olds, but not 18-month-olds, with this deficit more evident in males. Finally, Exp. 3 examined whether aging-related inflammation could account for declines in social behavior during late aging by administering naproxen (0, 7, 14, and 28 mg/kg; s.c.)—a non-steroidal anti-inflammatory drug—to 18-month-old females. Results from this study revealed that social behavior was unaffected by acute or repeated (6 days) naproxen, suggesting that aging-related social deficits in females may not be a consequence of a general aging-related inflammation and/or malaise. Together, these findings demonstrate that aging-related declines in social behavior are (i) specific to social stimuli and (ii) not indicative of a general state of aging-related debilitation. Thus, these findings establish working parameters for a highly tractable model in which the neural and hormonal mechanisms underlying aging-related declines in social behavior can be examined.

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Age-related scopolamine effects on social and individual behaviour in rats

Cited by 26 publications

References 40 publications

Long-Term Influence of Perinatal Asphyxia on the Social Behavior in Aging Rats

Long-Term Influence of Perinatal Asphyxia on the Social Behavior in Aging Rats

Social interactions in adolescent and adult Sprague–Dawley rats: Impact of social deprivation and test context familiarity

A working model for the assessment of disruptions in social behavior among aged rats: The role of sex differences, social recognition, and sensorimotor processes

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