Age-related serum levels of insulin-like growth factor-I, -II and IGF-binding protein-3 following myocardial infarction

Reeves, Isabelle; Abribat, Thierry; Laramee, Pierre; Jasmin, G.; Brazeau, Paul

doi:10.1054/ghir.2000.0143

Cited by 25 publications

(15 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in agreement with earlier reports on the effects of IGF-1 on myocardium from adult Wistar Kyoto rats (Cittadini et al 1998;Ren et al 1999) and human ventricles (Cittadini et al 1998;von et al 2003), in which IGF-1 did not show significant inotropic effect at concentrations below 10 nmol/L. There is also a negative correlation between daily IGF-1 plasma concentrations and age (Reeves et al 2000). There is also a negative correlation between daily IGF-1 plasma concentrations and age (Reeves et al 2000).…”

Section: Discussionsupporting

confidence: 92%

Prenatal cocaine alone and combined with nicotine alters ANG II and IGF-1 induced left atrial contractions in aging male offspring

Haddad

Scheer²,

Clarke³

et al. 2005

Can. J. Physiol. Pharmacol.

View full text Add to dashboard Cite

Prenatal cocaine or nicotine affects inotropic activity in the hearts of rat offspring. However, the long-term consequence of this exposure on the cardiac response to hormonal challenge is unknown. We assessed the inotropic effects of angiotensin II (ANG II) and insulin-like growth factor 1 (IGF-1) in the left atria of 19.0-24.5 month-old male rats exposed on gestation days 8-21 to 1 of 6 treatments: low cocaine (LC) (20 mg/kg) or high cocaine (HC) (40 mg/kg); 20 mg/kg cocaine and high nicotine (5 mg/kg nicotine) (LC/HN); 40 mg/kg cocaine and low nicotine (2.5 mg/kg nicotine) (HC/LN); pair fed: yoked to HC (PF); saline: injection of 0.9% NaCl (SAL). Isometric contractions were assessed by electrical stimulation of isolated left atria superfused with Tyrode solution (control) to which ANG II (10-7 mol/L, 20 min) and IGF-1 (10-8 mol/L, 20 min) in the presence of ANG II were added sequentially. Offspring in all cocaine groups showed a higher peak tension development (PTD) to ANG II than PF controls. This increase in PTD was attenuated by subsequent addition of IGF-1 in all except HC offspring. However, with the HC/LN combination the IGF-1 effect on PTD was again evident. The velocities of contraction and relaxation were positively affected by ANG II only in the combined prenatal drug groups; IGF-1 reduced only contraction velocity. Our data demonstrate that IGF-1 reverses the positive inotropic effect of ANG-II in atrial muscle of aging rats and that gestational exposure to only high doses of cocaine eliminates this protective response. It appears that combined prenatal exposure to cocaine and nicotine does not exacerbate the decline in cardiac function and responsiveness to inotropic drugs seen in the aging heart.

show abstract

Section: Discussionsupporting

confidence: 92%

Prenatal cocaine alone and combined with nicotine alters ANG II and IGF-1 induced left atrial contractions in aging male offspring

Haddad

Scheer²,

Clarke³

et al. 2005

Can. J. Physiol. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Recently Friberg et al (84) reported that non-diabetic patients who died after an acute myocardial infarction from CVD during 2 years of follow-up, had at admission significantly lower IGF-I levels than survivors. In two other studies, non-diabetic patients with myocardial infarction had significantly lower IGF-I levels at admission than age-and sex-matched healthy controls (85,86). In one of these latter studies older patients with a cardiac condition were less able to maintain their blood IGF-I levels during the recovery period than younger patients (85) (Fig.…”

Section: Igf-i Diabetes and The Heartmentioning

confidence: 88%

“…In two other studies, non-diabetic patients with myocardial infarction had significantly lower IGF-I levels at admission than age-and sex-matched healthy controls (85,86). In one of these latter studies older patients with a cardiac condition were less able to maintain their blood IGF-I levels during the recovery period than younger patients (85) (Fig. 3).…”

Section: Igf-i Diabetes and The Heartmentioning

confidence: 88%

The role of IGF-I in the development of cardiovascular disease in type 2 diabetes mellitus: is prevention possible?

Janssen

Lamberts

2002

European Journal of Endocrinology

View full text Add to dashboard Cite

The incidence of peripheral, cerebro-and cardiovascular disease (CVD) in patients with type 2 diabetes mellitus is approximately twice as high as in the non-diabetic population. Conventional cardiovascular risk factors such as plasma lipids, lipoproteins and hypertension only partially explain this excessive risk of developing atherosclerosis and CVD. Meta-analysis of studies performed in nondiabetic populations indicates that the risk of CVD increases continuously with glucose levels above 4.2 mmol/l. The glucose hypothesis suggests that treatment which normalizes glucose levels prevents or delays the long-term complications of diabetes mellitus. However, the outcome of the UK Prospective Diabetes Study demonstrates that glucose control does not completely prevent CVD. In healthy subjects, serum IGF-I levels peak in early adulthood, after which they gradually decrease with increasing age. Several observations suggest that there is a premature and progressive agerelated decline in serum IGF-I bioactivity in type 2 diabetics, which eventually results in a (relative) IGF-I deficiency. In type 2 diabetics, close relationships have been demonstrated between glycaemic control and serum IGF-I levels, with worse control being associated with lower IGF-I levels. Several studies (in non-diabetics) suggest that lowered circulating IGF-I levels account for a poor outcome of CVD. We previously observed in a population-based study that a genetically determined lowered IGF-I expression increases the risk of myocardial infarction with type 2 diabetes. This genetic approach overcomes the problem that cross-sectional studies cannot distinguish whether changes in IGF-I levels are a cause or a consequence of a disease. IGF-I is an important metabolic regulatory hormone. In addition, IGF-I suppresses myocardial apoptosis and improves myocardial function in various models of experimental cardiomyopathy. Compared with other growth factors, the 'survival' effect of IGF-I on myocardium seems rather unique. Therefore, we hypothesize that the premature and progressive decline in serum IGF-I bioactivity in ageing patients with type 2 diabetics is an important pathophysiological abnormality. It contributes not only to elevated glucose and lipid levels, but also to the progression and the poor outcome of CVD. If this hypothesis is proven to be right, treatment with IGF-I as an adjunct to insulin offers great potential and might not only improve metabolic control but also reduce the incidence and prevalence of CVD in type 2 diabetes patients. However, there is as yet no experimental evidence that long-term (replacement) treatment with IGF-I prevents, delays or reduces CVD in type 2 diabetes patients. Clinical trials are necessary to prove that long-term IGF-I treatment, preferably in the form of a bettertolerated IGF-I/IGF-binding protein-3 complex, improves the overall cardiovascular risk in type 2 diabetes.

show abstract

“…IGF-1 can stimulate myoblast cell proliferation in cell culture [78]. In aged humans, reduced serum levels of IGF-1 have been observed [79], a change that could account for differences in satellite cell activation and proliferation with age.…”

Section: Systemic Factors Of the Host Environmentmentioning

confidence: 99%

Intrinsic Changes and Extrinsic Influences of Myogenic Stem Cell Function During Aging

2007

View full text Add to dashboard Cite

The myogenic stem cell (satellite cell) is almost solely responsible for the remarkable regeneration of adult skeletal muscle fibers after injury. The availability and the functionality of satellite cells are the determinants of efficient muscle regeneration. During aging, the efficiency of muscle regeneration declines, suggesting that the functionality of satellite cells and their progeny may be altered. Satellite cells do not sit in isolation but rather are surrounded by, and influenced by, many extrinsic factors within the muscle tissue that can alter their functionality. These factors likely change during aging and impart both reversible and irreversible changes to the satellite cells and on their proliferating progeny. In this review, we discuss the possible mechanisms of impaired muscle regeneration with respect to the biology of satellite cells. Future studies that enhance our understanding of the interactions between stem cells and the environment in which they reside will offer promise for therapeutic applications in age-related diseases.

show abstract

Age-related serum levels of insulin-like growth factor-I, -II and IGF-binding protein-3 following myocardial infarction

Cited by 25 publications

References 24 publications

Prenatal cocaine alone and combined with nicotine alters ANG II and IGF-1 induced left atrial contractions in aging male offspring

Prenatal cocaine alone and combined with nicotine alters ANG II and IGF-1 induced left atrial contractions in aging male offspring

The role of IGF-I in the development of cardiovascular disease in type 2 diabetes mellitus: is prevention possible?

Intrinsic Changes and Extrinsic Influences of Myogenic Stem Cell Function During Aging

Contact Info

Product

Resources

About