Age related structural and functional changes in left ventricular performance in healthy subjects: a 2D echocardiographic study

Vriz, Olga; Pirisi, Mario; Habib, Eiad; Galzerano, Domenico; Fadel, Bahaa M.; Antonini‐Canterin, Francesco; Veldtman, Gruschen; Bossone, Eduardo

doi:10.1007/s10554-019-01665-y

Cited by 10 publications

(8 citation statements)

References 50 publications

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“…The statistically significant correlations of age with LV variables which were reported in these studies are also shown in Table 1 (Ref. [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]). LV mass (LVM) and LVM index (LVMi) data from the echocardiographic studies using Mmode have not been presented, in part because of evidence of the unreliability of echocardiographic assessment of LVM compared to CMR studies [34], but also because of doubts about the accuracy of echocardiography methods during aging.…”

Section: Age and Left Ventricular Structure And Pump Function -Echocardiographic Studiesmentioning

confidence: 59%

“…RWT was quantified in a study of 393 normotensive, non-obese adults of age range 18-85 years (42% women), RWT increased by 0.015 per 10 years, and this increase was seen in both males and females [26]. Vriz et al [26] performed 2D echocardiography on 778 healthy volunteers of age range 18-100 years (58% male) and also found an age-related increase in RWT.…”

Section: Cross-sectional Echocardiographic Studies Of Wall Thickness Lvedd and Rwtmentioning

confidence: 99%

“…Echocardiographic studies in which age was considered as a determinant of LV wall thickness, diameter and/or volumes in healthy subjects, and which included data from at least 100 individuals, are listed in Table 1 (Ref. [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]), along with information regarding the age and sex of the cohorts. The statistically significant correlations of age with LV variables which were reported in these studies are also shown in Table 1 (Ref.…”

Section: Age and Left Ventricular Structure And Pump Function -Echocardiographic Studiesmentioning

confidence: 99%

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Changes in left ventricular size, geometry, pump function and left heart pressures during healthy aging

Peverill

2021

Rev. Cardiovasc. Med.

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There are cross-sectional and longitudinal imaging studies using echocardiography and cardiac magnetic resonance in healthy adult subjects which have demonstrated associations of left ventricular (LV) structure and pump function with age. There are also crosssectional data regarding the relationships of age with invasively measured left heart chamber pressures. Increasing age is associated with decreases in LV end-diastolic volume (LVEDV), end-systolic volume (LVESV), end-diastolic length (LVEDL), stroke volume (SV) and cardiac output (CO), and increases in relative wall thickness (RWT), LV mass/LVEDV ratio (LVMVR) and ejection fraction (LVEF). Older age is not accompanied by a change in mean left atrial (LA) pressure, but there is both direct and indirect evidence which suggests that LV enddiastolic pressure (LVEDP) increases with age. LVEDV remains lower in older than younger subjects during fluid infusion and the resulting increases in LA pressure. The combination of an increase in LVEF with reductions of both SV and CO demonstrates an age-related increase in divergence between LVEF and LV pump function. A lower LVEDV in older compared to younger subjects can be characterized as an aging-related decrease in LV capacity, with the higher LVEDP in older subjects also indicating a reduction of preload reserve.

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Section: Age and Left Ventricular Structure And Pump Function -Echocardiographic Studiesmentioning

confidence: 59%

Section: Cross-sectional Echocardiographic Studies Of Wall Thickness Lvedd and Rwtmentioning

confidence: 99%

Section: Age and Left Ventricular Structure And Pump Function -Echocardiographic Studiesmentioning

confidence: 99%

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Changes in left ventricular size, geometry, pump function and left heart pressures during healthy aging

Peverill

2021

Rev. Cardiovasc. Med.

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“…In a cross-sectional study of 105 male individuals from the National Institute on Aging Volunteer Longitudinal Study Program, there was no age-related difference in fractional shortening amongst participants. This was one of the first studies to show that resting LV contractile function was preserved with advancing age [23] . Different studies have shown discordant results regarding the change in LVEF with aging.…”

Section: Systolic Functionmentioning

confidence: 90%

Changes in cardiac structure and function with aging

Agrawal¹,

Nagueh²

2022

JCA

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Aging is associated with progressive changes in cardiac structure and function. The prevalence of cardiovascular risk factors and disease also increases profoundly with advancing age. Therefore, understanding the spectrum of physiological changes in the aging heart is crucial for the identification and risk stratification of cardiovascular disease. In this review, we discuss echocardiographic features of age-related cardiac remodeling.

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“…One hundred and fifty-five consecutive patients with idiopathic uncomplicated mildto-moderate HTN and one hundred and forty-five healthy subjects were enrolled by 13 RIGHT-NET participating centers [7,8]. Healthy subjects were recruited, as previously reported, among volunteers without structural heart disease on TTE and/or history of any cardiovascular disease and/or any systemic diseases known to affect the cardiovascular system [7][8][9][10][11]. Patients were defined to be hypertensive if office systolic blood pressure (SBP) values were ≥140 mmHg and/or diastolic blood pressure (DBP) values were ≥90 mmHg on three consecutive visits or if they were on anti-hypertensive therapy [4].…”

Section: Study Populationmentioning

confidence: 99%

Right Heart Pulmonary Circulation Unit Response to Exercise in Patients with Controlled Systemic Arterial Hypertension: Insights from the RIGHT Heart International NETwork (RIGHT-NET)

Vriz

Palatini

Rudski

et al. 2022

JCM

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Background. Systemic arterial hypertension (HTN) is the main risk factor for the development of heart failure with preserved ejection fraction (HFpEF). The aim of the study was was to assess the trends in PASP, E/E’ and TAPSE during exercise Doppler echocardiography (EDE) in hypertensive (HTN) patients vs. healthy subjects stratified by age. Methods. EDE was performed in 155 hypertensive patients and in 145 healthy subjects (mean age 62 ± 12.0 vs. 54 ± 14.9 years respectively, p < 0.0001). EDE was undertaken on a semi-recumbent cycle ergometer with load increasing by 25 watts every 2 min. Left ventricular (LV) and right ventricular (RV) dimensions, function and hemodynamics were evaluated. Results. Echo-Doppler parameters of LV and RV function were lower, both at rest and at peak exercise in hypertensives, while pulmonary hemodynamics were higher as compared to healthy subjects. The entire cohort was then divided into tertiles of age: at rest, no significant differences were recorded for each age group between hypertensives and normotensives except for E/E’ that was higher in hypertensives. At peak exercise, hypertensives had higher pulmonary artery systolic pressure (PASP) and E/E’ but lower tricuspid annular plane systolic excursion (TAPSE) as age increased, compared to normotensives. Differences in E/E’ and TAPSE between the 2 groups at peak exercise were explained by the interaction between HTN and age even after adjustment for baseline values (p < 0.001 for E/E’, p = 0.011 for TAPSE). At peak exercise, the oldest group of hypertensive patients had a mean E/E’ of 13.0, suggesting a significant increase in LV diastolic pressure combined with increased PASP. Conclusion. Age and HTN have a synergic negative effect on E/E’ and TAPSE at peak exercise in hypertensive subjects.

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Age related structural and functional changes in left ventricular performance in healthy subjects: a 2D echocardiographic study

Cited by 10 publications

References 50 publications

Changes in left ventricular size, geometry, pump function and left heart pressures during healthy aging

Changes in left ventricular size, geometry, pump function and left heart pressures during healthy aging

Changes in cardiac structure and function with aging

Right Heart Pulmonary Circulation Unit Response to Exercise in Patients with Controlled Systemic Arterial Hypertension: Insights from the RIGHT Heart International NETwork (RIGHT-NET)

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