Age-related structural modulation of T lymphocyte-associated CD45 isoforms

Abdul-Salam, Fatma; Moulana, Mohadetheh; Mansour, Mohamed H.

doi:10.1016/s0047-6374(99)00114-1

Cited by 7 publications

(2 citation statements)

References 28 publications

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“…In a biological setting, gal-1 can skew the cytokine response of T cells toward Th2, possibly through the cell death pathway of Th1 cells. Furthermore, changes in CD45 and CD43 glycosylation, specifically sialylation, are associated with aging and the age-related reduction in CD4 + T cell responsiveness (Abdul-Salam et al 2000). In total, it is now clear that the active modulation of CD45 glycosylation in T cells is a galectin-dependent regulatory pathway during T cell development and apoptosis.…”

Section: Glycome Changes Lead To Molecular and Cellular Functional DImentioning

confidence: 99%

Infection, inflammation and host carbohydrates: A Glyco-Evasion Hypothesis

Kreisman

Cobb

2012

Glycobiology

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Microbial immune evasion can be achieved through the expression, or mimicry, of host-like carbohydrates on the microbial cell surface to hide from detection. However, disparate reports collectively suggest that evasion could also be accomplished through the modulation of the host glycosylation pathways, a mechanism that we call the "Glyco-Evasion Hypothesis". Here, we will summarize the evidence in support of this paradigm by reviewing three separate bodies of work present in the literature. We review how infection and inflammation can lead to host glycosylation changes, how host glycosylation changes can increase susceptibility to infection and inflammation and how glycosylation impacts molecular and cellular function. Then, using these data as a foundation, we propose a unifying hypothesis in which microbial products can hijack host glycosylation to manipulate the immune response to the advantage of the pathogen. This model reveals areas of research that we believe could significantly improve our fight against infectious disease.

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Section: Glycome Changes Lead To Molecular and Cellular Functional DImentioning

confidence: 99%

Infection, inflammation and host carbohydrates: A Glyco-Evasion Hypothesis

Kreisman

Cobb

2012

Glycobiology

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show abstract

“…On the basis of the documented cross-reactivity between UEA-I and L. tetragonolobus lectin in binding terminally a1,2 fucosylated epitopes (Pereira and Kabat, 1974) and the similar tissue distribution pattern of their respective ligands (Farr and Anderson, 1985;Mansour et al, 2005), the possibility that the 50 kDa glycoprotein carries both UEA-I and L. tetragonolobus ligands on mature thymocytes may not be excluded. Furthermore, the 180 kDa component may correspond in terms of the microheterogeneity of its constituent isoforms and the estimated molecular weight and acidic pI 0 s of each isoform to CD45RO, the low-molecular-weight (180 kDa) member of the CD45 family of molecules, known to be expressed selectively by the PNA À mature thymocytes of adult mice (Abdul-Salam et al, 2000). Similarly, the 114 kDa component may also correspond in terms of molecular weight and acidic pI to the lowmolecular-weight (115 kDa) isoform of CD43, the major sialoglycoprotein expressed by thymocytes and T lymphocytes (Jones et al, 1994).…”

Section: Article In Pressmentioning

confidence: 99%