Age-related Treatment Outcome of Unruptured Intracranial Aneurysm

Abstract

Summary:The aim of this study was to determine age-related differences in outcome between clipping and coiling in patients with intracranial aneurysms. We retrospectively analyzed 377 consecutive patients (clipping, 304 cases and coiling, 73 cases) dividing them into four groups based on age as follows: <50 years, 50 to 59 years, 60 to 69 years, and ≥70 years. Outcomes were assessed in the perioperative period and 1 year later. Of the cases with perioperative symptomatic events, 7 (2.3%), including 4 cases (1.3%) of symptomatic ischemic stroke, were treated with clipping and none was treated with coiling. All cases of symptomatic perioperative ischemic stroke after clipping occurred in patients aged 60 years (p = 0.027). Events at 1 year occurred only after clipping in 10 cases (3.3%) and after coiling in none of the cases. Eight of 10 patients had chronic subdural hematoma, and all of them were >60 years old (p = 0.028). Favorable outcome was observed for both clipping and coiling in both age groups. Clipping was related to risks of perioperative ischemic stroke and chronic subdural hematoma within 1 year in patients >60 years of age.