Age‐Related Trends in Home Blood Pressure, Home Pulse Rate, and Day‐to‐Day Blood Pressure and Pulse Rate Variability Based on Longitudinal Cohort Data: The Ohasama Study

Satoh, Michihiro; Metoki, Hirohito; Asayama, Kei; Murakami, Takahisa; Inoue, Ryusuke; Tsubota‐Utsugi, Megumi; Matsuda, Ayako; Hirose, Takuo; Hara, Azusa; Obara, Taku; Kikuya, Masahiro; Nomura, Kyoko; Hozawa, Atsushi; Imai, Yutaka

doi:10.1161/jaha.119.012121

Cited by 18 publications

(14 citation statements)

References 45 publications

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“…Both studies included a younger population compared to our study. Older age is associated with higher BPV [16,47], as was the case in this study. In older age, frailty increases as a consequence of age-related decline in multiple physiological systems, leading to vulnerability to minor stressors [48].…”

Section: U N C O R R E C T E D a U T H O R P R O O Fsupporting

confidence: 61%

Day-To-Day Home Blood Pressure Variability and All-Cause Mortality in a Memory Clinic Population

Haverkamp

Melis

Claassen

et al. 2022

JAD

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Background: High day-to-day blood pressure variability (BPV) has been associated with an increased risk for cognitive decline and mortality in the general population. Whether BPV is associated with increased all-cause mortality in older people with cognitive impairment is unknown. Objective: To investigate the association between day-to-day home BPV and all-cause mortality in older patients attending a memory clinic. Methods: We included 279 patients attending a memory clinic, who measured home blood pressure (BP) for 7 consecutive days in the morning and evening. Within-subject BPV was defined as the variation independent of the mean (VIM). Time-to-death was verified through the Dutch population registry. Cox proportional hazard regression was used. Separate analyses were performed for morning-to-morning and evening-to-evening BPV. Results: Mean age was 73±9 years, dementia and mild cognitive impairment were diagnosed in 35% and 34% respectively, and mean home BP was 139/79 mmHg. After a mean follow-up of 3.2 years, 52 patients had died. Neither day-to-day systolic nor diastolic VIM were associated with mortality (adjusted hazard ratio [HR] systolic VIM: 0.99, 95% -CI 0.92–1.06, p = 0.770, HR diastolic VIM: 1.04, 95% -CI 0.93–1.17, p = 0.517). When morning and evening measurements were analyzed separately, systolic morning-to-morning VIM was associated with mortality (adjusted HR: 1.09, 95% -CI 1.01–1.18, p = 0.033). Conclusion: In this study, day-to-day BPV was not associated with all-cause mortality in patients attending a memory clinic. However, morning-to-morning BPV was. Due to the short assessment window, there is still a lack of clarity; hence future research is warranted to clarify the role of all BPV components in aging.

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Section: U N C O R R E C T E D a U T H O R P R O O Fsupporting

confidence: 61%

Day-To-Day Home Blood Pressure Variability and All-Cause Mortality in a Memory Clinic Population

Haverkamp

Melis

Claassen

et al. 2022

JAD

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“…In the present study, the increment of diastolic BP in fiscal year 2020 among treated participants seemed to be smaller than that among untreated participants (approximately 0.4 mmHg vs. 1 mmHg, respectively). The small increase in diastolic BP in fiscal year 2020 among treated participants might have been caused by the lack of vascular elasticity due to the relatively long-term exposure to high BP [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…The trends in BP and prevalence rate of BP ≥130/≥80 mmHg were assessed using the repeated measures linear mixed model and the logistic generalized linear mixed model with autoregressive order 1 (AR (1)) correlation structure, respectively. AR (1) is a standard method for assessing the covariance matrix in mixed model analyses of longitudinal data [ 24 ]. Fiscal year was treated as categorical to assess the detailed BP changes during the fiscal years 2015–2020 (degrees of freedom [DF] = 5).…”

Section: Methodsmentioning

confidence: 99%

“…For sensitivity analysis, we conducted stratification analysis according to alcohol consumption or smoking status. Stratification analysis according to age (55 years) was performed for the diastolic BP changes since diastolic BP decreases with aging in an old population [ 24 , 25 ]. To strictly consider collinearity, we restricted the covariates in the model.…”

Section: Methodsmentioning

confidence: 99%

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Time-series analysis of blood pressure changes after the guideline update in 2019 and the coronavirus disease pandemic in 2020 using Japanese longitudinal data

et al. 2022

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We assessed blood pressure (BP) changes during fiscal years (April to March of the following year) 2015–2020 to clarify the effect of the state of emergency due to the coronavirus disease 2019 (COVID-19) pandemic in 2020. We then considered BP in 2019 separately, as the Japanese hypertension guidelines were updated in 2019. The present retrospective cohort study extracted data from 157,510 Japanese individuals aged <75 years (mean age: 50.3 years, men: 67.5%) from the annual health check-up data of the DeSC database. The trends in BP were assessed using a repeated measures linear mixed model. After adjusting for the month of health check-ups to exclude seasonal BP variation, systolic BP linearly increased during fiscal years 2015–2018. From the value estimated by the trend in 2015–2018, systolic BP was lower by ≤1 mmHg in fiscal year 2019 among the treated participants. Meanwhile, systolic/diastolic BP (95% confidence interval) increased by 2.11 (1.97–2.24)/1.05 (0.96–1.14) mmHg for untreated women ( n = 43,292), 1.60 (1.51–1.70)/1.17 (1.11–1.24) mmHg for untreated men ( n = 88,479), 1.92 (1.60–2.23)/0.46 (0.25–0.67) mmHg for treated women ( n = 7855), and 1.00 (0.79–1.21)/0.39 (0.25–0.53) mmHg for treated men ( n = 17,884) in fiscal year 2020. These increases remained time-dependent covariates after adjustments for age, body mass index, alcohol consumption, smoking, physical activity, and blood sampling indices. Social change due to the pandemic might have increased BP by approximately 1–2/0.5–1 mmHg. Meanwhile, only a slight decrease in BP was observed immediately after the guideline update in Japan.

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“…In the general population of Ohasama, both home BP and day-by-day BP variability increase with age. 21 The home BP variability is a risk factor for the development of cardiovascular events, independent of the average home BP, [22][23][24] and is associated with renal function. 25 In elderly hypertensive patients, the BP variability is also reported as a risk factor for mortality 26,27 and cardiovascular death 28 and a predictor of arterial stiffness progression.…”

Section: Discussionmentioning

confidence: 99%

Single‐pill combination of cilnidipine, an l‐/n‐type calcium channel blocker, and valsartan reduces the day‐by‐day variability of morning home systolic blood pressure in patients with treated hypertension: A sub‐analysis of the HOPE‐combi survey

Kario

Matsuda

Nagahama

et al. 2021

J of Clinical Hypertension

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Recent hypertension management guidelines recommend the use of fixed-dose single-pill combinations (SPCs) to achieve lower blood pressure (BP) levels. 1-4 In particular, the hypertension guidelines of the European Society of Cardiology and European Society of Hypertension recommend that a fixed-dose SPC is initiated as firstline treatment. 5 We have previously reported that the SPC of cilnidipine (10 mg) and valsartan (80 mg) (SPC of Cil/Val) is useful to reduce home BP in patients with uncontrolled hypertension with sympathetic hyperactivity. 6 Cil, a component of the SPC of Cil/Val and unique

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Age‐Related Trends in Home Blood Pressure, Home Pulse Rate, and Day‐to‐Day Blood Pressure and Pulse Rate Variability Based on Longitudinal Cohort Data: The Ohasama Study

Cited by 18 publications

References 45 publications

Day-To-Day Home Blood Pressure Variability and All-Cause Mortality in a Memory Clinic Population

Day-To-Day Home Blood Pressure Variability and All-Cause Mortality in a Memory Clinic Population

Time-series analysis of blood pressure changes after the guideline update in 2019 and the coronavirus disease pandemic in 2020 using Japanese longitudinal data

Single‐pill combination of cilnidipine, an l‐/n‐type calcium channel blocker, and valsartan reduces the day‐by‐day variability of morning home systolic blood pressure in patients with treated hypertension: A sub‐analysis of the HOPE‐combi survey

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