Age, sex and the association between skin test responses and IgE titres with asthma

Mohammad, Hasan R; Belgrave, Danielle; Kopec-Harding, Kamilla; Murray, Clare; Simpson, Angela; Čustović, Adnan

doi:10.1111/pai.12534

Cited by 40 publications

(34 citation statements)

References 31 publications

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“…Most of the demographic characteristics were equally distributed between the cases and the controls in our cohort; males were more prevalent in the asthmatic group, a characteristic well described in this age group . Increased television attendance time was noted in the asthmatics, despite no reported differences in physical activity, although a vicious circle of physical activity limitation and reduced fitness in asthmatics has previously been shown .…”

Section: Discussionsupporting

confidence: 63%

Contribution of repeated infections in asthma persistence from preschool to school age: Design and characteristics of the PreDicta cohort

Xepapadaki

Bachert

Finotto

et al. 2018

Pediatric Allergy Immunology

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Section: Discussionsupporting

confidence: 63%

Contribution of repeated infections in asthma persistence from preschool to school age: Design and characteristics of the PreDicta cohort

Xepapadaki

Bachert

Finotto

et al. 2018

Pediatric Allergy Immunology

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“…Simpson et al, working with the same group of children, using latent variable modeling in 221 participants with a positive IgE to one or more components, showed that 61 allergen components clustered into three component groups, and that sensitization to one component that includes 27 components of plants, animals, and fungi, were strongly associated with asthma (OR=8.20; 95% CI: 3.49–19.24; p <0.001) and lower volume exhaled during the first second (forced expiratory volume in 1 second) 52. Finally, age and sex should be taken into account when interpreting the results of SPT and specific IgE measurement, and age- and sex-specific normative data are needed for these allergic tests 53. That could mean that all of those algorithms for predicting asthma that include specific IgE or SPT, for example, all the mAPIs, had this problem 8,9,23…”

Section: Discussionmentioning

confidence: 99%

Factors predicting persistence of early wheezing through childhood and adolescence: a systematic review of the literature

Rodríguez‐Martínez¹,

Sossa-Briceño²,

Castro-Rodriguez³

2017

JAA

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BackgroundFor the early identification of persistent asthma symptoms among young children with recurrent wheezing, it would be helpful to identify all available studies that have identified at least one factor for predicting the persistence of early wheezing. The objective of the present study was to perform a systematic review of all studies that have identified factors that predict the persistence of symptoms among young patients with recurring wheezing.MethodsA systematic review of relevant studies was conducted through searching in MEDLINE, EMBASE, CINHAL, and SCOPUS databases up to June 2016. Studies that identified predictors of persistence of wheezing illness among young children with recurrent wheezing were retrieved. Two independent reviewers screened the literature and extracted relevant data.ResultsThe literature search returned 649 references, 619 of which were excluded due to their irrelevance. Five additional studies were identified from reference lists, and 35 studies were finally included in the review. Among all the identified predictors, the most frequently identified ones were the following: family asthma or atopy; personal history of atopic diseases; allergic sensitization early in life; and frequency, clinical pattern, or severity of wheezing/symptoms.ConclusionParental asthma (especially maternal), parental allergy, eczema, allergic rhinitis, persistent wheezing, wheeze without colds, exercise-induced wheeze, severe wheezing episodes, allergic sensitization (especially polysensitization), eosinophils (blood or eosinophil cationic protein in nasal sample), and fraction of exhaled nitric oxide were risk factors predicting persistence of early wheezing through school age. All of them are included in conventional algorithms, for example, Asthma Predictive Index and its modifications, for predicting future asthma.

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“…It is known that boys are more susceptible than girls before puberty, but less than girls after puberty. Many theories exists to explain this phenomena including: dysnapsis due to different sized lungs in boys and girls, increased allergy (more IgE production in boys), different innate and adaptive immune responses in boys and girls, and the influence of sex hormones (Shames et al, 1998;Papadopoulos et al, 2004;Mohammad et al, 2016). The incidence of asthma is also related to the use of life saving medical interventions in premature and newborn children such as oxygen supplementation or mechanical ventilation due to physical permanent damage to the newborn's lungs (Davidson and Berkelhamer, 2017).…”

Section: Introductionmentioning

confidence: 99%

Why Do Intrauterine Exposure to Air Pollution and Cigarette Smoke Increase the Risk of Asthma?

Wang

Chen

Chan

et al. 2020

Front. Cell Dev. Biol.

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The prevalence of childhood asthma is increasing worldwide and increased in utero exposure to environmental toxicants may play a major role. As current asthma treatments are not curative, understanding the mechanisms underlying the etiology of asthma will allow better preventative strategies to be developed. This review focuses on the current understanding of how in utero exposure to environmental factors increases the risk of developing asthma in children. Epidemiological studies show that maternal smoking and particulate matter exposure during pregnancy are prominent risk factors for the development of childhood asthma. We discuss the changes in the developing fetus due to reduced oxygen and nutrient delivery affected by intrauterine environmental change. This leads to fetal underdevelopment and abnormal lung structure. Concurrently an altered immune response and aberrant epithelial and mesenchymal cellular function occur possibly due to epigenetic reprograming. The sequelae of these early life events are airway remodeling, airway hyperresponsiveness, and inflammation, the hallmark features of asthma. In summary, exposure to inhaled oxidants such as cigarette smoking or particulate matter increases the risk of childhood asthma and involves multiple mechanisms including impaired fetal lung development (structural changes), endocrine disorders, abnormal immune responses, and epigenetic modifications. These make it challenging to reduce the risk of asthma, but knowledge of the mechanisms can still help to develop personalized medicines.

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Age, sex and the association between skin test responses and IgE titres with asthma

Abstract: Background: Skin prick tests (SPTs) and allergen-specific serum IgE (sIgE) measurements are the

Cited by 40 publications

References 31 publications

Contribution of repeated infections in asthma persistence from preschool to school age: Design and characteristics of the PreDicta cohort

Contribution of repeated infections in asthma persistence from preschool to school age: Design and characteristics of the PreDicta cohort

Factors predicting persistence of early wheezing through childhood and adolescence: a systematic review of the literature

Why Do Intrauterine Exposure to Air Pollution and Cigarette Smoke Increase the Risk of Asthma?

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