Age-sex, ethnic and genetic peculiarities of high normal arterial blood pressure in residents of Mountain Shoria

Abstract

Aim. To study the prevalence of a high normal arterial blood pressure (HNABP) depending on the age-sex and ethnic characteristics of the population of Mountain Shoria and its association with the cardiovascular risk factors and genetic markers. Materials and methods. We performed a cross-sectional study of the compactly settled population in the isolated areas of Mountain Shoria (Orton and Ust-Kabyrza villages) and in urban-type settlement Sheregesh. The sample of the Shor population was 901 subjects (284 men and 617 women). As the comparison group, we examined 508 non-indigenous (newly arrived) subjects (153 men and 355 women) in the indicated villages. All the respondents underwent a general clinical laboratory and instrumental examination. Polymorphisms of genes ACE (I/D, rs 4340), АGT (c.803T>C, rs699), AGTR1 (А1166С, rs5186), ADRB1 (с.145A>G, Ser49Gly, rs1801252), ADRA2B (I/D, rs 28365031), MTHFR (c.677С>Т, Ala222Val, rs1801133) and NOS3 (VNTR, 4b/4a) were tested using polymerase chain reaction. Results. The factors associated with HNABP are analyzed in the present research. In the group of the Shors the following conditions were associated with this pathology: obesity (OR 2.03), its abdominal type (OR 1.98), genotype I/D of АСЕ gene (OR 1.80) and genotype А/С of AGTR1 gene (OR 2.03); in the non-indigenous ethnic group - obesity (OR 2.39), abdominal obesity (OR 3.17) and genotype D/D of АСЕ gene (OR 3.43). In the Shor patients with HNABP the prevalence of left ventricular myocardial hypertrophy (28.1%) and albuminuria (17.3%) appeared to be higher as compared to the non-indigenous subjects - 17.2%, (р=0.047) and 5.1% (р=0.049), respectively. Conclusion. The present study demonstrated a high prevalence of HNABP in the population of Mountain Shoria depending on ethnicity. Therefore, such patients require monitoring for an early detection of the increased blood pressure, control of risk factors, preventive examinations and dispensary observation.