Age, sex, race, initial fitness, and response to training: the HERITAGE Family Study

Skinner, James S.; Jaskólski, Artur; Jaskólska, Anna; Krasnoff, Joanne B.; Gagnon, Jacques; Leon, Arthur S.; Rao, D. C.; Wilmore, Jack H.; Bouchard, Claude

doi:10.1152/jappl.2001.90.5.1770

Cited by 217 publications

(195 citation statements)

References 17 publications

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“…Our results are in line with previous studies in healthy non-CF people, showing an inverse relationship between the levels of fitness at baseline and the magnitude of improvement in V9O 2 ,peak and suggesting a normal training response in CF [5,13]. These findings are of particular interest because NIXON et al [10] and PIANOSI et al [19] have shown that the likelihood of survival is greater in CF with a higher level of aerobic fitness.…”

Section: Discussionsupporting

confidence: 92%

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Do responses to exercise training in cystic fibrosis depend on initial fitness level?

Gruber

Orenstein²,

Braumann³

2011

Eur Respir J

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The aim of our study was to evaluate the responses to an exercise programme with respect to initial fitness in subjects with cystic fibrosis (CF).72 subjects (42 female) aged 10-43 yrs (forced expiratory volume in 1 s of 62.0¡26.7% predicted) were included. Participants were divided into three groups based on peak oxygen uptake expressed as % predicted. Subjects participated in a multifaceted rehabilitation programme, including five-times-a-week exercise training, for 6 weeks. Exercise and ventilatory capacity were determined by a maximal incremental cycling test. Oxygen uptake, workload and peak cardiac frequency at peak and submaximal workload were used as parameters for exercise capacity and responsiveness to training.Lung function values were significantly different between groups (p,0.05), and increased after training (p,0.05) only in groups with a lower initial fitness level. Responsiveness to training showed differences between groups (p,0.05) at peak and ventilatory anaerobic threshold (VAT; p,0.05), with higher improvements in subjects with lower initial fitness level.The improvements in exercise parameters in CF at peak and VAT depended on the fitness level at baseline, independent of lung function. These improvements seen after training were comparable with those seen in healthy subjects, suggesting that responsiveness to exercise is similar in CF and in healthy untrained persons.

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Section: Discussionsupporting

confidence: 92%

“…Healthy people with lower peak oxygen uptake (V9O 2 ,peak) can improve more than those who have already trained or are physically active [5]. In subjects with CF, a positive relationship between physical activity and V9O 2 ,peak has been found [6,7].…”

mentioning

confidence: 99%

Do responses to exercise training in cystic fibrosis depend on initial fitness level?

Gruber

Orenstein²,

Braumann³

2011

Eur Respir J

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“…For example, the HERITAGE Family Study investigated intra-individual variation in responsiveness to regular exercise training in healthy, sedentary individuals and showed that lower initial fitness values were associated with greater relative changes. 14 There are only few studies that have investigated the response to an exercise program with respect to initial fitness level in diseased individuals. A study among cystic fibrosis patients showed that a 6-week exercise program led to significantly different training responses between initially fit and unfit groups, with greater improvements in subjects with a lower initial fitness level.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of exercise training in SCT patients-who benefits most?

Wiskemann

Kuehl

Dreger

et al. 2013

Bone Marrow Transplant

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Patients undergoing allo-HCT often experience a substantial loss in physical performance. We have recently published the general effectiveness of an exercise intervention in 105 allo-HCT patients on physical performance and psychosocial well-being. However, predictor variables for differentiated treatment response remained unclear. To determine the impact of basic physical performance on treatment response, we assessed muscle strength and endurance performance at four assessment points before and after allo-HCT. The exercise group started training 2 weeks before admission and ended 6-8 weeks after discharge. Comparing initially fit with unfit classified patients, the fit patients lost 31% of the strength of the knee-extensors, whereas the unfit patients lost only 1% (Po0.05). For endurance capacity, fit patients lost 4% of their walking capability, whereas unfit patients gained 13% (Po0.05). The individual percent change was statistically different at the 0.05 level in all measures of physical performance. Individual training response in allo-HCT patients strongly depends on the initial physical performance level. Unfit patients can be trained safely and may benefit more from this exercise intervention than fit patients. This result is of major clinical relevance and should encourage hematologists to promote exercise even more in impaired/unfit allo-HCT patients.

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“…The study suggested that race has no significant effect on the response of VO 2 max to exercise training [17].…”

Section: Discussionmentioning

confidence: 81%

Cardiovascular Response to Qigong Training in European and Asian Participants

Ladawan¹

2017

ACIM

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Background: Qigong exercise has been shown to improve cardiovascular function in clinical populations. Ethnicity differences in cardiovascular responses to Qigong exercise have not been studied extensively, especially regarding females. Thus, the purpose of this study was to compare cardiovascular effects to Qigong training between healthy, sedentary Asian and European female participants. Methods:In this study, European and Asian participants were lifelong European and Asian residents respectively. Six healthy, sedentary Asian females (aged 53.0±5.7 years) and 6 European healthy, sedentary females (aged 49.6±7.4 years) performed Qigong exercise 3 days per week for 8 weeks followed by 12 weeks of no exercise. Blood pressure and heart rate values at rest and during submaximal exercise were assessed at baseline (T1), after the end of the training program (T2), and after 12 weeks of exercise cessation (T3). Discussion: Qigong training resulted in lower heart rates to submaximal exercise in both populations and lower blood pressure values especially in people with higher values at baseline (European participants). However, beneficial effects on blood pressure disappeared after 12 weeks of exercise cessation. Therefore, training continuation is of essential importance. Further research is required to examine whether our SBP findings in response to Qigong training were due to higher baseline blood pressure, sample bias (migration) or ethnicity differences. Results: European participants showed a significant reduction in

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Age, sex, race, initial fitness, and response to training: the HERITAGE Family Study

Cited by 217 publications

References 17 publications

Do responses to exercise training in cystic fibrosis depend on initial fitness level?

Do responses to exercise training in cystic fibrosis depend on initial fitness level?

Efficacy of exercise training in SCT patients-who benefits most?

Cardiovascular Response to Qigong Training in European and Asian Participants

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